Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chun-Shik Shin"'
Autor:
Chun-Shik Shin, Shuxia Meng, Spiros D. Garbis, Annie Moradian, Robert W. Taylor, Michael J. Sweredoski, Brett Lomenick, David C. Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Most mitochondrial proteins are imported from the cytosol and must fold in the mitochondria. Here, the authors show that the mitochondrial protease LONP1 plays a critical role in the mtHSP70 chaperone system independently of its protease activity.
Externí odkaz:
https://doaj.org/article/8a65c368ecc04a4481d331a0a80d8431
Autor:
Chun-Shik Shin, Prashant Mishra, Jeramie D. Watrous, Valerio Carelli, Marilena D’Aurelio, Mohit Jain, David C. Chan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The factors that limit the nutrient flexibility of cells remain largely unknown. Here, the authors identify the glutamate/cysteine antiporter xCT in a genetic screen for glucose dependency and show it determines the ability of cells to survive under
Externí odkaz:
https://doaj.org/article/ffc32426233347f1b087b7734c74c44d
Autor:
Jeramie D. Watrous, Valerio Carelli, David C. Chan, Marilena D'Aurelio, Prashant Mishra, Mohit Jain, Chun Shik Shin
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature communications, vol 8, iss 1
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Nature communications, vol 8, iss 1
As noted by Warburg, many cancer cells depend on the consumption of glucose. We performed a genetic screen to identify factors responsible for glucose addiction and recovered the two subunits of the xCT antiporter (system xc−), which plays an antio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc09e02f7a04cea627c1ea76337b754f
http://europepmc.org/articles/PMC5413954
http://europepmc.org/articles/PMC5413954
Autor:
Dong-Hun Han, Won-Ki Huh, Kang-In Kim, Yeonji Chang, Yong-Min Kwon, Ji-Yun Kim, Chun-Shik Shin
Publikováno v:
Genomics & Informatics. 8:177-184
The target of rapamycin (TOR) signaling pathway is a conserved pathway that regulates eukaryotic cell growth in response to environmental cues. Chemical genomic approaches that profile rapamycin sensitivity of yeast deletion strains have given insigh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53db4c690077e66c727e00729abf482a
https://doi.org/10.5808/gi.2010.8.4.177
https://doi.org/10.5808/gi.2010.8.4.177
Publikováno v:
Molecular Microbiology. 79:633-646
Yak1 is a member of an evolutionarily conserved family of Ser/Thr protein kinases known as dual-specificity Tyr phosphorylation-regulated kinases (DYRKs). Yak1 was originally identified as a growth antagonist, which functions downstream of Ras/PKA si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9615435028c087f7336a190904844946
https://doi.org/10.1111/j.1365-2958.2010.07471.x
https://doi.org/10.1111/j.1365-2958.2010.07471.x
Publikováno v:
Genomics & Informatics. 7:203-207
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved in several cellular processes, including ribosome biogenesis, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5554611ef1d718aab5e728f9d04b464
https://doi.org/10.5808/gi.2009.7.4.203
https://doi.org/10.5808/gi.2009.7.4.203
Publikováno v:
Journal of Cell Science. 122:2089-2099
The target of rapamycin (TOR) signaling pathway plays crucial roles in the regulation of eukaryotic cell growth. In Saccharomyces cerevisiae, nitrogen sources in the extracellular environment activate the TOR signaling pathway. However, the precise m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef13fd7aba3f38cc5b6759ab0d4743d6
https://doi.org/10.1242/jcs.047191
https://doi.org/10.1242/jcs.047191
Publikováno v:
Clinical Endocrinology. 51:153-158
OBJECTIVE Previous studies have shown that the rapid ACTH stimulation test using a low dose of 1 microg is more sensitive than that using 250 microg ACTH for detecting subtle cases of adrenal insufficiency. However, there are controversies for the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a76f3eec4306f22848764893ae1a118
https://doi.org/10.1046/j.1365-2265.1999.00773.x
https://doi.org/10.1046/j.1365-2265.1999.00773.x
Autor:
Chun-Shik Shin, Won-Ki Huh
Publikováno v:
Autophagy. 7(8)
It has been reported in various model organisms that autophagy and the target of rapamycin complex 1 (TORC1) signaling are strongly involved in eukaryotic cell aging and decreasing TORC1 activity extends longevity by an autophagy-dependent mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dedbfa28649f6feaa947f75c49ead99f
https://pubmed.ncbi.nlm.nih.gov/21490424
https://pubmed.ncbi.nlm.nih.gov/21490424
Publikováno v:
Molecular microbiology. 79(3)
Yak1 is a member of an evolutionarily conserved family of Ser/Thr protein kinases known as dual-specificity Tyr phosphorylation-regulated kinases (DYRKs). Yak1 was originally identified as a growth antagonist, which functions downstream of Ras/PKA si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d2807aeb6c31b5c5b2e20111d578d11
https://pubmed.ncbi.nlm.nih.gov/21255108
https://pubmed.ncbi.nlm.nih.gov/21255108