Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Chun-Seok Cho"'
Autor:
Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and in
Externí odkaz:
https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
Autor:
Sung Rye Park, Sim Namkoong, Leon Friesen, Chun-Seok Cho, Zac Zezhi Zhang, Yu-Chih Chen, Euisik Yoon, Chang H. Kim, Hojoong Kwak, Hyun Min Kang, Jun Hee Lee
Publikováno v:
Cell Reports, Vol 32, Iss 8, Pp 108077- (2020)
Summary: DNA damage often induces heterogeneous cell-fate responses, such as cell-cycle arrest and apoptosis. Through single-cell RNA sequencing (scRNA-seq), we characterize the transcriptome response of cultured colon cancer cell lines to 5-fluorour
Externí odkaz:
https://doaj.org/article/facdc4df9ebe4a08abfce4382f5413e6
Autor:
Seung-Hyun Ro, Xiang Xue, Sadeesh K Ramakrishnan, Chun-Seok Cho, Sim Namkoong, Insook Jang, Ian A Semple, Allison Ho, Hwan-Woo Park, Yatrik M Shah, Jun Hee Lee
Publikováno v:
eLife, Vol 5 (2016)
The mTOR complex 1 (mTORC1) and endoplasmic reticulum (ER) stress pathways are critical regulators of intestinal inflammation and colon cancer growth. Sestrins are stress-inducible proteins, which suppress both mTORC1 and ER stress; however, the role
Externí odkaz:
https://doaj.org/article/a1a04df440cf407aa51e8d0b621b689e
Autor:
Sumeet Solanki, Katherine Sanchez, Varun Ponnusamy, Vasudha Kota, Hannah N. Bell, Chun-Seok Cho, Allison H. Kowalsky, Michael Green, Jun Hee Lee, Yatrik M. Shah
Publikováno v:
Gastroenterology.
Colorectal cancer (CRC) is a devastating disease that is highly modulated by dietary nutrients. Mechanistic target of rapamycin complex 1 (mTORC1) contributes to tumor growth and limits therapy responses. Growth factor signaling is a major mechanism
Autor:
Jun Hee Lee, Allison H. Kowalsky, Seung-Hyun Ro, Alyson Sujkowski, Susan V. Brooks, Carol S. Davis, Bondong Gu, Robert Wessells, Sim Namkoong, Michael Karin, Myungjin Kim, Ian A. Semple, Tyler Cobb, Boyoung Kim, Chun-Seok Cho
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications
Nature communications, vol 11, iss 1
Exercise is among the most effective interventions for age-associated mobility decline and metabolic dysregulation. Although long-term endurance exercise promotes insulin sensitivity and expands respiratory capacity, genetic components and pathways m
Autor:
Chun-Seok Cho, Yongsung Kim, Sung-Rye Park, Boyoung Kim, Carol Davis, Irene Hwang, Susan V. Brooks, Jun Hee Lee, Myungjin Kim
Publikováno v:
Autophagy
By promoting anabolism, MTORC1 is critical for muscle growth and maintenance. However, genetic MTORC1 upregulation promotes muscle aging and produces age-associated myopathy. Whether MTORC1 activation is sufficient to produce myopathy or indirectly p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8b8935152c7fd58ebc2102e8cd7b11
https://europepmc.org/articles/PMC9542799/
https://europepmc.org/articles/PMC9542799/
Autor:
Goo Jun, Sung-Rye Park, Jun Hee Lee, Chun-Seok Cho, Myungjin Kim, Hyun-Min Kang, Jer-En Hsu, Jingyue Xi
Spatial barcoding technologies have the potential to reveal histological details of transcriptomic profiles; however, they are currently limited by their low resolution. Here we report Seq-Scope, a spatial barcoding technology with a resolution almos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96188fb887de1fe0f5ef1be21cf4dc6e
https://doi.org/10.1101/2021.01.25.427807
https://doi.org/10.1101/2021.01.25.427807
Publikováno v:
Am J Physiol Endocrinol Metab
During nutritional overload and obesity, hepatocyte function is grossly altered, and a subset of hepatocytes begins to accumulate fat droplets, leading to nonalcoholic fatty liver disease (NAFLD). Recent single-cell studies revealed how nonparenchyma
During nutritional overload and obesity, hepatocyte function is grossly altered, and a subset of hepatocytes begins to accumulate fat droplets, leading to non-alcoholic fatty liver disease (NAFLD). Recent single cell studies revealed how non-parenchy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f9ceb4174ac4c78879bf150c447e4d7
Autor:
Amanda James, Myungjin Kim, Shuangcheng Wu, Yatrik M. Shah, Boyoung Kim, Uhn-Soo Cho, Joel K. Greenson, Ian A. Semple, Allison H. Kowalsky, Sim Namkoong, Chun-Seok Cho, Sumeet Solanki, M. A. Tohamy, Bondong Gu, Jun Hee Lee, Sung-Rye Park
Publikováno v:
Cell Discovery, Vol 5, Iss 1, Pp 1-18 (2019)
Cell Discovery
Cell Discovery
mTORC1 is a protein kinase important for metabolism and is regulated by growth factor and nutrient signaling pathways, mediated by the Rheb and Rag GTPases, respectively. Here we provide the first animal model in which both pathways were upregulated