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Autor:
Richard A. Willis, Karl Folkers, Chun-Que Ye, Per H. Langsjoen, Phillip Richardson, Li-Jun Xia, Hiroo Tamagawa
Publikováno v:
Proceedings of the National Academy of Sciences. 87:8931-8934
Lovastatin is clinically used to treat patients with hypercholesterolemia and successfully lowers cholesterol levels. The mechanism of action of lovastatin is inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme involved in the bi