Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chun-Kit Yuen"'
An interferon-integrated mucosal vaccine provides pan-sarbecovirus protection in small animal models
Autor:
Chun-Kit Yuen, Wan-Man Wong, Long-Fung Mak, Joy-Yan Lam, Lok-Yi Cheung, Derek Tsz-Yin Cheung, Yau-Yee Ng, Andrew Chak-Yiu Lee, Nanshan Zhong, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract A pan-sarbecovirus or pan-betacoronavirus vaccine that can prevent current and potential future beta-coronavirus infections is important for fighting possible future pandemics. Here, we report a mucosal vaccine that cross-protects small anim
Externí odkaz:
https://doaj.org/article/7be46c5f05934f0bb145e230a3413bda
Publikováno v:
Emerging Microbes and Infections, Vol 11, Iss 1, Pp 964-967 (2022)
SARS-CoV-2 has caused the COVID-19 pandemic since early 2020. As of January 2022, the worldwide spreading of SARS-CoV-2 leads to approximately 0.35 billion of human infections and five millions of deaths. Current vaccination is one of the effective w
Externí odkaz:
https://doaj.org/article/fb18a349a39f47c08fa62848e6e4d0ed
Autor:
Joy-Yan Lam, Wan-Man Wong, Chun-Kit Yuen, Yau-Yee Ng, Chun-Hin San, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1550 (2023)
Developing recombinant proteins as nasal vaccines for inducing systemic and mucosal immunity against respiratory viruses is promising. However, additional adjuvants are required to overcome the low immunogenicity of protein antigens. Here, a self-adj
Externí odkaz:
https://doaj.org/article/db5f0eb7645447d0a493351b1e518ecf
Autor:
Joy-Yan Lam, Chun-Kit Yuen, Jonathan Daniel Ip, Wan-Man Wong, Kelvin Kai-Wang To, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 2685-2696 (2020)
ABSTRACTThe newly emerged betacoronavirus, SARS-CoV-2, causes the COVID-19 pandemic since December 2019 with more than 35 million laboratory confirmed human infections and over one million deaths within nine months. The genome of SARS-CoV-2 continues
Externí odkaz:
https://doaj.org/article/7f539bf0a15d4cb988090801c53df0e0
Autor:
Chun-Kit Yuen, Joy-Yan Lam, Wan-Man Wong, Long-Fung Mak, Xiaohui Wang, Hin Chu, Jian-Piao Cai, Dong-Yan Jin, Kelvin Kai-Wang To, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Emerging Microbes and Infections, Vol 9, Iss 1, Pp 1418-1428 (2020)
ABSTRACTThe Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infection
Externí odkaz:
https://doaj.org/article/43eb16139bd041b3b649842243444b5b
Autor:
Wing-Yu Lui, Chun-Kit Yuen, Can Li, Wan Man Wong, Pak-Yin Lui, Chi-Ho Lin, Kwok-Hung Chan, Hanjun Zhao, Honglin Chen, Kelvin K. W. To, Anna J. X Zhang, Kwok-Yung Yuen, Kin-Hang Kok
Publikováno v:
Emerging Microbes and Infections, Vol 8, Iss 1, Pp 662-674 (2019)
ABSTRACTInfluenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, which can be rescued by co-infecti
Externí odkaz:
https://doaj.org/article/f33b858fe2994e339e8ecd9c7eb0e18f
Autor:
Xiaohui Wang, Joy-Yan Lam, Wan-Man Wong, Chun-Kit Yuen, Jian-Piao Cai, Shannon Wing-Ngor Au, Jasper Fuk-Woo Chan, Kelvin K. W. To, Kin-Hang Kok, Kwok-Yung Yuen
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT An accurate diagnostic test for early severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is the key weapon to control the coronavirus disease 2019 (COVID-19) pandemic. We previously reported that the SARS-CoV-2 genome con
Externí odkaz:
https://doaj.org/article/efb17c320812470e85875644b9bc5c4e
Autor:
Jessica Pihl, Jasper Fuk-Woo Chan, Pok Man Lai, Jeffrey D. Esko, Li Sheng, Ronald A. Li, Yushen Du, Ren Sun, Lars Pache, Ronghui Liang, Thomas Mandel Clausen, Kwok-Yung Yuen, Hongzhe Sun, Chun-Kit Yuen, Yuan Pu, Zi-Wei Ye, Chris Chung-Sing Chan, Jianli Cao, Xue-Hui Cai, Anna Jinxia Zhang, Dong Wang, Sumit K. Chanda, Yan-Dong Tang, Ivan Hung, Andrew Chak-Yiu Lee, Wing-Kuk Au, Ko-Yung Sit, Kong-Hung Sze, Vincent Kwok-Man Poon, Dong-Yan Jin, Honglin Chen, Kin-Hang Kok, Runming Wang, Naoko Matsunaga, Wan Xu, Hin Chu, Kaiming Tang, Chit-Ying Lau, Shuofeng Yuan, Juntaek Oh, Chris Chun-Yiu Chan, Laura Riva, Yu-Yuan Zhang, Xiangzhi Meng, Xin Yin
Publikováno v:
Yuan, S, Yin, X, Meng, X, Chan, J F W, Ye, Z W, Riva, L, Pache, L, Chan, C C Y, Lai, P M, Chan, C C S, Poon, V K M, Lee, A C Y, Matsunaga, N, Pu, Y, Yuen, C K, Cao, J, Liang, R, Tang, K, Sheng, L, Du, Y, Xu, W, Lau, C Y, Sit, K Y, Au, W K, Wang, R, Zhang, Y Y, Tang, Y D, Clausen, T M, Pihl, J, Oh, J, Sze, K H, Zhang, A J, Chu, H, Kok, K H, Wang, D, Cai, X H, Esko, J D, Hung, I F N, Li, R A, Chen, H, Sun, H, Jin, D Y, Sun, R, Chanda, S K & Yuen, K Y 2021, ' Clofazimine broadly inhibits coronaviruses including SARS-CoV-2 ', Nature, vol. 593, pp. 418–423 . https://doi.org/10.1038/s41586-021-03431-4
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 20031 and Middle East respiratory syndrome (MERS) in 20122. Treatment optio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4add8439d17979216ce3a29cb0b95caa
https://doi.org/10.1038/s41586-021-03431-4
https://doi.org/10.1038/s41586-021-03431-4
Autor:
Xiaohui Wang, Kelvin K. W. To, Wan Man Wong, Jian Piao Cai, Chun Kit Yuen, Long Fung Mak, Jasper Fuk-Woo Chan, Kwok-Yung Yuen, Joy Lam, Kin-Hang Kok, Hin Chu, Dong-Yan Jin
Publikováno v:
Emerging Microbes & Infections
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The Coronavirus disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2 virus, is now causing a tremendous global health concern. Since its first appearance in December 2019, the outbreak has already caused over 5.8 million infections worldw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e3d804cc3e43470f1dc93cf82acee8
https://doi.org/10.1080/22221751.2020.1780953
https://doi.org/10.1080/22221751.2020.1780953
Autor:
Kin-Hang Kok, Pak-Yin Lui, Kelvin K. W. To, Can Li, Anna J. X. Zhang, Hanjun Zhao, Chi-Ho Lin, Wing-Yu Lui, Kwok-Hung Chan, Kwok-Yung Yuen, Chun-Kit Yuen, Honglin Chen, Wan Man Wong
Publikováno v:
Emerging Microbes & Infections
Influenza defective interfering (DI) particles are replication-incompetent viruses carrying large internal deletion in the genome. The loss of essential genetic information causes abortive viral replication, which can be rescued by co-infection with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f6812389202b127e8b986219770f42
http://europepmc.org/articles/PMC6534226
http://europepmc.org/articles/PMC6534226