Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Chun-Hwa Chen"'
Autor:
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83160 (2014)
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w
Externí odkaz:
https://doaj.org/article/e5078208d61149adbf9f92f8697b3132
Autor:
Chih-Feng Tien, Wan-Ting Tsai, Chun Hwa Chen, Hui-Ju Chou, Mingzi M. Zhang, Jhe-Jhih Lin, En-Ju Lin, Shih-Syong Dai, Yueh-Hsin Ping, Chia-Yi Yu, Yi-Ping Kuo, Wei-Hsiang Tsai, Hsin-Wei Chen, Guann-Yi Yu
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104709- (2022)
Summary: Post-translational modifications (PTMs), such as glycosylation and palmitoylation, are critical to protein folding, stability, intracellular trafficking, and function. Understanding regulation of PTMs of SARS-CoV-2 spike (S) protein could he
Externí odkaz:
https://doaj.org/article/7e8eaed9e1394cfe84ce788de24baf0c
Autor:
Chun-Hwa Chen, 陳春華
96
On September 21, 1999, a violent earthquake of ML=7.3 which is named to be the Chi-Chi Earthquake attacked Taiwan. The Tsaoling landslide is one of the gigantic rock avalanches triggered by the earthquake. In such huge avalanche, the precauti
On September 21, 1999, a violent earthquake of ML=7.3 which is named to be the Chi-Chi Earthquake attacked Taiwan. The Tsaoling landslide is one of the gigantic rock avalanches triggered by the earthquake. In such huge avalanche, the precauti
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/36011534122757075189
Autor:
Chun-Hwa Chen, 陳俊樺
94
Amphibian skin is a rich resource of antimicrobial peptides, serves as the first line of defense of creatures attacked by microbes. The antimicrobial peptide studied here is an antimicrobial peptide from skin secretion of toad, Bombina maxima
Amphibian skin is a rich resource of antimicrobial peptides, serves as the first line of defense of creatures attacked by microbes. The antimicrobial peptide studied here is an antimicrobial peptide from skin secretion of toad, Bombina maxima
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/69919300566154249020
Autor:
Mu-Chun Li, Mohane Selvaraj Coumar, Shu-Yu Lin, Yih-Shyan Lin, Guan-Lin Huang, Chun-Hwa Chen, Tzu-Wen Lien, Yi-Wen Wu, Yen-Ting Chen, Ching-Ping Chen, Yu-Chen Huang, Kai-Chia Yeh, Chen-Ming Yang, Bikashita Kalita, Shiow-Lin Pan, Tsu-An Hsu, Teng-Kuang Yeh, Chiung-Tong Chen, Hsing-Pang Hsieh
Publikováno v:
Journal of Medicinal Chemistry. 66:2566-2588
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22f10aa3b2e138d40b42d98f5b533645
https://doi.org/10.1021/acs.jmedchem.2c01434
https://doi.org/10.1021/acs.jmedchem.2c01434
Autor:
Fu Ming Kuo, Chin Yu Lin, Chun Feng Chang, An Siou Li, Hsing Pang Hsieh, Teng Kuang Yeh, Jen Shin Song, Shu Yu Lin, Chun Hwa Chen, Mohane Selvaraj Coumar, Po Chu Kuo, Sing Yi Wang, Mu Chun Li, Wen-Hsing Lin, Chen Ming Yang, Pei Yi Chen, John T.A. Hsu
Publikováno v:
Bioorganic chemistry. 98
In an effort to develop new cancer therapeutics, we have reported clinical candidate BPR1K871 (1) as a potentanticancercompound in MOLM-13 and MV4-11 leukemia models, as well as in colorectal and pancreatic animal models. As BPR1K871 lacks oral bioav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5477e2465975a7f72145a43d0b9932
https://pubmed.ncbi.nlm.nih.gov/32171993
https://pubmed.ncbi.nlm.nih.gov/32171993
Autor:
Sing Yi Wang, Pei Yi Chen, Yung Chang Hsu, Teng Kuang Yeh, Hsu Yi Sun, Chun Hwa Chen, Kai-Chia Yeh, Shu Yu Lin, Su Ying Wu, Hsing Pang Hsieh, Ching Ping Chen, Chiung-Tong Chen, Hui Yi Shiao, Yi Hui Peng, Tzu Wen Lien, Fu Ming Kuo, Yi Yu Ke, Wen-Hsing Lin, Chang Ying Chu, Tsu An Hsu
Publikováno v:
Journal of medicinal chemistry. 62(22)
Epidermal growth factor receptor (EGFR)-targeted therapy in non-small cell lung cancer represents a breakthrough in the field of precision medicine. Previously, we have identified a lead compound, furanopyrimidine 2, which contains a (S)-2-phenylglyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c0a7f2358d5cec8f896161d0fefb55
https://pubmed.ncbi.nlm.nih.gov/31560541
https://pubmed.ncbi.nlm.nih.gov/31560541
Autor:
Wen Chieh Wang, Yun I. Chang, Fu Ming Kuo, Po Chu Kuo, Ching Ping Chen, Chiung-Tong Chen, Jen Shin Song, Mohane Selvaraj Coumar, Ching Chuan Kuo, Chun Wei Chang, An Siou Li, Ming Hsine Wu, Yi Yu Ke, Teng Kuang Yeh, Sing Yi Wang, Hui Yi Shiao, Kuei Jung Yen, Yung Chang Hsu, Chun Hwa Chen, Wen-Hsing Lin, Hsing Pang Hsieh, John T.A. Hsu, Pei Yi Chen, Chen Lung Huang, Chuan Shih
Publikováno v:
Oncotarget
// Yung Chang Hsu 1, * , Mohane Selvaraj Coumar 2, * , Wen-Chieh Wang 1, * , Hui-Yi Shiao 1, * , Yi-Yu Ke 1 , Wen-Hsing Lin 1 , Ching-Chuan Kuo 1 , Chun-Wei Chang 1 , Fu-Ming Kuo 1 , Pei-Yi Chen 1 , Sing-Yi Wang 1 , An-Siou Li 1 , Chun-Hwa Chen 1 , P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02a2eb341741edb83e6b9a1de9e85c4
https://doi.org/10.18632/oncotarget.13369
https://doi.org/10.18632/oncotarget.13369
Autor:
John T.A. Hsu, Chun Hwa Chen, Hsing Pang Hsieh, Wen-Hsing Lin, Yih Shyan Lin, Biing-Jiun Uang, Chun Feng Chang, Wen Chieh Wang, Yi Yu Ke, Po Chu Kuo
Publikováno v:
European Journal of Medicinal Chemistry. 124:186-199
Aurora kinases have emerged as important anticancer targets so that there are several inhibitors have advanced into clinical study. Herein, we identified novel indazole derivatives as potent Aurora kinases inhibitors by utilizing in silico fragment-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d67e326223f52607fb84050f02ad26
https://doi.org/10.1016/j.ejmech.2016.08.026
https://doi.org/10.1016/j.ejmech.2016.08.026
Autor:
John T.A. Hsu, Jian-Sung Wu, Shiu Hwa Yeh, Shu Yu Lin, Wen-Chi Hsiao, Andrew Yueh, Jen-Shin Song, Chia-Ling Hsieh, Yi-Hui Peng, Ming-Shiu Hung, Lung-Chun Lee, Chia-Yeh Liu, Shau-Hua Ueng, Su-Ying Wu, Mine-Hsine Wu, Chuan Shih, Shu-Yi Lin, Teng-Kuang Yeh, Fang-Yu Liao, Chun-Hwa Chen
Publikováno v:
Journal of Medicinal Chemistry. 58:7807-7819
A structure-based virtual screening strategy, comprising homology modeling, ligand-support binding site optimization, virtual screening, and structure clustering analysis, was developed and used to identify novel tryptophan 2,3-dioxygenase (TDO) inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f6d48ff04d4c03236ee06acbd01311
https://doi.org/10.1021/acs.jmedchem.5b00921
https://doi.org/10.1021/acs.jmedchem.5b00921