Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Chun-Bong Synn"'
Autor:
Dong Kwon Kim, Chun-Bong Synn, Seung Min Yang, Seongsan Kang, Sujeong Baek, Se-Woong Oh, Gyu-Jin Lee, Ho-Woong Kang, Young-Sung Lee, Jong Suk Park, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Doo Jae Lee, Hyun-Woo Kim, June Dong Park, Sung Sook Lee, Ji Yun Lee, Jii Bum Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Hey Ryun Kim, Kyoung-Ho Pyo, Byoung Chul Cho
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Among cancer cells, indoleamine 2, 3-dioxygenase1 (IDO1) activity has been implicated in improving the proliferation and growth of cancer cells and suppressing immune cell activity. IDO1 is also responsible for the catabolism of tryptophan to kynuren
Externí odkaz:
https://doaj.org/article/30185622547a479687c15ffe8e327c40
Autor:
Wongeun Lee, Dong Kwon Kim, Chun-Bong Synn, Hee Kyu Lee, Sungho Park, Dong-Sik Jung, Yewon Choi, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Seul Lee, Soyeon Lee, Yunjoo Joo, Eun Ji Lee, Mi Ran Yun, Seong Gu Heo, Wookyeom Yang, Ji Eun Jung, Eun Kyung Kim, Jooyeon Park, June Dong Park, Doo Jae Lee, Hyeon-Woo Kim, Sun Min Lim, Min Hee Hong, Beung-Chul Ahn, Jii Bum Lee, Kyoung-Ho Pyo
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
A recently developed treatment strategy for lung cancer that combines immune checkpoint inhibitors with chemotherapy has been applied as a standard treatment for lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC), and it has improved
Externí odkaz:
https://doaj.org/article/407f5970dae34dc5907c67d56bd5e79e
Autor:
Chun‐Bong Synn, Sung Eun Kim, Hee Kyu Lee, Min‐Hwan Kim, Jae Hwan Kim, Ji Min Lee, Ha Ni Jo, Wongeun Lee, Dong Kwon Kim, Youngseon Byeon, Young Seob Kim, Mi Ran Yun, Chae‐Won Park, Jiyeon Yun, Sangbin Lim, Seong Gu Heo, San‐Duk Yang, Eun Ji Lee, Seul Lee, Hunmi Choi, You Won Lee, Jae Seok Cho, Do Hee Kim, Sungho Park, Jung‐Ho Kim, Yewon Choi, Sung Sook Lee, Beung‐Chul Ahn, Chang Gon Kim, Sun Min Lim, Min Hee Hong, Hye Ryun Kim, Kyoung‐Ho Pyo, Byoung Chul Cho
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Abstract Objectives AXL‐mediated activation of aberrant tyrosine kinase drives various oncogenic processes and facilitates an immunosuppressive microenvironment. We evaluated the anti‐tumor and anti‐metastatic activities of SKI‐G‐801, a sma
Externí odkaz:
https://doaj.org/article/2810ccf729dc4cf68402dc5c21aa1ea6
Autor:
Youngrae Lee, Sujeong Baek, Dong Kwon Kim, Yeri Lee, Donggeon Kim, Seongin Jo, Sang Kyun Lim, Young Sook Shin, Soonsang Kwon, Seung Min Yang, Young Taek Kim, Seong-San Kang, Chun-Bong Synn, Kwangmin Na, Mi Hyun Kim, Heekyung Han, Yu Jin Han, Sungwoo Lee, Jae Hwan Kim, Mi Ran Yun, Youngseon Byeon, Young Seob Kim, Ji Yun Lee, Jii Bum Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Kyoung-Ho Pyo, Byoung Chul Cho, Taeyoung Yoon
Publikováno v:
Cancer Research. 83:3234-3234
Prostaglandin E2 (PGE2) is widely recognized as one of the major bioactive lipids that, with the striking regenerative potential, promote drug-resistance in cancer cells as well as immune evasion in the tumor microenvironment (TME). Primarily driven
Autor:
Seul Lee, Jae-Hwan Kim, Kwangmin Na, Seung Min Yang, Dong Kwon Kim, Sujeong Baek, Seong-san Kang, Yu Jin Han, Chun-Bong Synn, Mi hyun Kim, Heekyung Han, Young Taek Kim, Sungwoo Lee, Youngseon Byeon, Young Seob Kim, Ji Yun Lee, Jii Bum Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Kyoung-Ho Pyo, Byoung Chul Cho
Publikováno v:
Cancer Research. 83:6780-6780
Heterogeneity in resistant to immunotherapies of tumor microenvironment (TME) has been implicated in immunotherapies to cause immune evasion or drug resistance. This study was conducted to explore the heterogeneity of TME through multiplex IHC, spati
Autor:
DongKwon Kim, Sujeong Baek, Seung Min Yang, Yu Jin Han, Seong-san Kang, Chun-Bong Synn, Mi Hyun Kim, Heekyung Han, Kwangmin Na, Young Taek Kim, Sungwoo Lee, Taedong Han, Hyounmie Doh, Jongho Cho, Dajeong Kim, Daewon Cha, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Mi Ran Yun, Ji Yun Lee, Jii Bum Lee, Chang Gon Kim, Min Hee Hong, Sun Min Lim, Byoung Chul Cho, Kyoung-Ho Pyo
Publikováno v:
Cancer Research. 83:5107-5107
Background: The Aryl hydrocarbon receptor (AhR) is one of the most predominant regulators of cancer metabolism. The AhR exerts important immunosuppressive functions by activating Treg cells and myeloid-derived suppressor cells and repressing CD8+ eff
Autor:
Sun Min Lim, Chun-Bong Synn, Seong-san Kang, DongKwon Kim, Soo-Hwan Lee, Sujeong Baek, Seung Min Yang, Yu Jin Han, Mi hyun Kim, Heekyung Han, Kwangmin Na, Young Taek Kim, Sungwoo Lee, Mi Ran Yun, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Jii Bum Lee, Ji Yun Lee, Chang Gon Kim, Min Hee Hong, Kyoung-Ho Pyo, Joshua Curtin, Bharvin Patel, Isabelle Bergiers
Publikováno v:
Cancer Research. 83:5865-5865
Introduction: Unmet needs exist for immunotherapy targeting PD-1/PD-L1 in head and neck squamous cell carcinoma (HNSCC) and lung squamous cell carcinoma (LUSC) due to its suboptimal response. Amivantamab, a bispecific antibody targeting epidermal gro
Autor:
Kyoung Ho Pyo, Hong In Yoon, Y. G. Kim, Jaehyung Jung, In-Ho Seo, Chun-Bong Synn, Su-Hyung Park, Soonmyung Paik, Yong Il Lee, Jeong-Eun Kwak, Yun Jeong Lee, Kyung Hwan Kim, Seongjin Choi, Hyo Sup Shim, Chang Gon Kim, Min Hee Hong, Hye Ryun Kim, Ellen Janine Kim, Beung-Chul Ahn, Eui-Cheol Shin
Publikováno v:
European Journal of Cancer. 143:113-126
Background The predictive value of immune monitoring with circulating CD8+ T lymphocytes for treatment response to programmed cell death protein 1 (PD-1) inhibitors has not been explored in non-small-cell lung cancer (NSCLC), prompting us to investig
Autor:
Chun‐Bong Synn, Sung Eun Kim, Hee Kyu Lee, Min‐Hwan Kim, Jae Hwan Kim, Ji Min Lee, Ha Ni Jo, Wongeun Lee, Dong Kwon Kim, Youngseon Byeon, Young Seob Kim, Mi Ran Yun, Chae‐Won Park, Jiyeon Yun, Sangbin Lim, Seong Gu Heo, San‐Duk Yang, Eun Ji Lee, Seul Lee, Hunmi Choi, You Won Lee, Jae Seok Cho, Do Hee Kim, Sungho Park, Jung‐Ho Kim, Yewon Choi, Sung Sook Lee, Beung‐Chul Ahn, Chang Gon Kim, Sun Min Lim, Min Hee Hong, Hye Ryun Kim, Kyoung‐Ho Pyo, Byoung Chul Cho
Publikováno v:
Clinical & Translational Immunology, Vol 11, Iss 1, Pp n/a-n/a (2022)
Clinical & Translational Immunology
Clinical & Translational Immunology
Objectives AXL‐mediated activation of aberrant tyrosine kinase drives various oncogenic processes and facilitates an immunosuppressive microenvironment. We evaluated the anti‐tumor and anti‐metastatic activities of SKI‐G‐801, a small‐mole
Autor:
Kyoung-Ho Pyo, Dong Kwon Kim, Se-Woong Oh, Gyu-Jin Lee, Ho-Woong Kang, Jae Hwan Kim, Youngseon Byeon, Young Seob Kim, Chun-Bong Synn, Wongeun Lee, Su Hwan Lee, Seul Lee, Seung Min Yang, Soyeon Lee, Yunjoo Joo, Eun Ji Lee, Sun Min Lim, Byoung Chul Cho
Publikováno v:
Cancer Research. 82:5481-5481
Background: The IDO is an enzyme responsible for catabolizing tryptophan (Trp) to kynurenine (Kyn). The kynurenine exert important immunosuppressive functions by activating Treg cells and myeloid-derived suppressor cells. YH29407 is a novel IDO1 inhi