Neuronal nitric oxide synthase modulation of intracellular Ca2+ handling overrides fatty acid potentiation of cardiac inotropy in hypertensive rats

Autor: Chae Hun Leem, Yue Wang, Chun Zi Jin, Sung Joon Kim, Jeong Hoon Lee, Yin Hua Zhang, Chun Li Jin, Jin Chul Paeng, Zai Hao Zhao, Jong Wan Park, Ming Zhe Yin, Seunggyun Ha, Keon Wook Kang, Peng Jin

Publikováno v: Jin, C L, Yin, M Z, Paeng, J C, Seunggyun, H, Lee, J H, Jin, P, Jin, C Z, Hao Zhao, Z, Wang, Y, Kang, K W, Leem, C H, Park, J-W, Kim, S J & Zhang, Y 2017, ' Neuronal nitric oxide synthase modulation of intracellular Ca 2+ handling overrides fatty acid-potentiation of cardiac inotropy in hypertensive rats ', Pflügers Archiv European Journal of Physiology, pp. 1-13 . https://doi.org/10.1007/s00424-017-1991-1

Cardiac neuronal nitric oxide synthase (nNOS) is an important molecule that regulates intracellular Ca2+ homeostasis and contractility of healthy and diseased hearts. Here, we examined the effects of nNOS on fatty acid (FA) regulation of left ventric

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb36a981f6c59bc464ab84a49329242
https://doi.org/10.1007/s00424-017-1991-1

Neuronal nitric oxide synthase modulation of intracellular Ca

Autor: Chun Li, Jin, Ming Zhe, Yin, Jin Chul, Paeng, Seunggyun, Ha, Jeong Hoon, Lee, Peng, Jin, Chun Zi, Jin, Zai Hao, Zhao, Yue, Wang, Keon Wook, Kang, Chae Hun, Leem, Jong-Wan, Park, Sung Joon, Kim, Yin Hua, Zhang

Publikováno v: Pflugers Archiv : European journal of physiology. 469(10)

Cardiac neuronal nitric oxide synthase (nNOS) is an important molecule that regulates intracellular Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae0cb9583db8756e3a0996c9d91ee9ea
https://pubmed.ncbi.nlm.nih.gov/28534086

Neuronal nitric oxide synthase is up-regulated by angiotensin II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes

Autor: Jae Gon Kim, Young Min Bae, Chun Zi Jin, Yue Wang, Cheng Ri Che, Yin Hua Zhang, Ji Hyun Jang, Sung Joon Kim, Jun Shi

Publikováno v: Jin, C Z, Jang, J H, Wang, Y, Kim, J G, Bae, Y M, Shi, J, Che, C R, Kim, S J & Zhang, Y H 2012, ' Neuronal nitric oxide synthase is up-regulated by angiotensin II and attenuates NADPH oxidase activity and facilitates relaxation in murine left ventricular myocytes ', Journal of molecular and cellular cardiology, vol. 52, no. 6, pp. 1274-1281 . https://doi.org/10.1016/j.yjmcc.2012.03.013, https://doi.org/10.1016/j.yjmcc.2012.03.013

Angiotensin II (Ang II) is critical in myocardial pathogenesis, mostly via stimulating NADPH oxidase. Neuronal nitric oxide synthase (nNOS) has recently been shown to play important roles in modulating myocardial oxidative stress and contractility. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e86a5ba5d12d2ecc40923acef294b75f
https://doi.org/10.1016/j.yjmcc.2012.03.013

Synthesis of Novel 8-alkylamino-5, 6-dihydro-4H-benzo[f] [1,2,4]triazolo [4,3-a]azepines as Anticonvulsant Agents

Autor: Chun-Zi Jin, Feng-Yu Piao, Rongbi Han, Hui-Fan Wu

Publikováno v: CNSneurological disorders drug targets. 15(10)

A series of new 8-alkylamino-5, 6-dihydro-4H-benzo[f][1,2,4]triazolo [4,3-a]azepine derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol (scPTZ) test, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::677a35861fe6981cb8cdc77db0ed6f3b
https://pubmed.ncbi.nlm.nih.gov/26996166

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

Autor: Ju Hong Jeon, Ji Hyun Jang, Yin Hua Zhang, Shigeo Godo, Hiroaki Shimokawa, Guangyu Wu, Chun Zi Jin, Jung Nyeo Chun, Sung Joon Kim, Zhe Hu Jin

Publikováno v: Jang, J H, Chun, J H, Godo, S, Wu, G, Shimokawa, H, Jin, C Z, Jeon, J H, Kim, S J, Jin, Z H & Zhang, Y H 2015, ' ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes ', Basic Research in Cardiology, vol. 110, no. 21 . https://doi.org/10.1007/s00395-015-0477-6

Angiotensin II (Ang II), a potent precursor of hypertrophy and heart failure, upregulates neuronal nitric oxide synthase (nNOS or NOS1) in the myocardium. Here, we investigate the involvement of type 1 and 2 angiotensin receptors (AT1R and AT2R) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc6376518600196cfa16852267e1f70b
https://www.research.manchester.ac.uk/portal/en/publications/ros-and-endothelial-nitric-oxide-synthase-enosdependent-trafficking-of-angiotensin-ii-type-2-receptor-begets-neuronal-nos-in-cardiac-myocytes(2cd47fc6-56b1-42fe-aa5c-c85dd0ae6144).html