Výsledky vyhledávání - "Chun Zhang Yang"

Akademický článek

Metabolic plasticity of IDH1-mutant glioma cell lines is responsible for low sensitivity to glutaminase inhibition

Publikováno v: Cancer & Metabolism, Vol 8, Iss 1, Pp 1-14 (2020)

Abstract Background Targeting glutamine metabolism in cancer has become an increasingly vibrant area of research. Mutant IDH1 (IDH1 mut ) gliomas are considered good candidates for targeting this pathway because of the contribution of glutamine to th

Externí odkaz: https://doaj.org/article/642fe869ab0144aeb501e954fc515524

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IDH-mutated gliomas promote epileptogenesis through d-2-hydroxyglutarate-dependent mTOR hyperactivation

Autor: Armin Mortazavi, Islam Fayed, Muzna Bachani, Tyrone Dowdy, Jahandar Jahanipour, Anas Khan, Jemima Owotade, Stuart Walbridge, Sara K Inati, Joseph Steiner, Jing Wu, Mark Gilbert, Chun Zhang Yang, Mioara Larion, Dragan Maric, Alexander Ksendzovsky, Kareem A Zaghloul

Publikováno v: Neuro Oncol

Background Uncontrolled seizures in patients with gliomas have a significant impact on quality of life and morbidity, yet the mechanisms through which these tumors cause seizures remain unknown. Here, we hypothesize that the active metabolite d-2-hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95fc3a80162deb09996df0577fa975fd
https://pubmed.ncbi.nlm.nih.gov/35533066

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