Zobrazeno 1 - 10
of 147
pro vyhledávání: '"Chun Y. Seow"'
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-14 (2024)
Abstract Background Understanding the characteristics of pulmonary resistance and elastance in relation to the location of airway narrowing, e.g., tracheal stenosis vs. intrapulmonary airway obstruction, will help us understand lung function characte
Externí odkaz:
https://doaj.org/article/727e34b7fcd24e23b643b9e35922883b
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-7 (2023)
Abstract Background Deep inspiration (DI) has been shown to induce bronchodilation and bronchoprotection in bronchochallenged healthy subjects, but not in asthmatics. Strain-induced relaxation of airway smooth muscle (ASM) is considered one of the fa
Externí odkaz:
https://doaj.org/article/88bb675be24646d494ac66c29379e117
Publikováno v:
Biology, Vol 13, Iss 2, p 115 (2024)
Rho-kinase inhibitors have been identified as a class of potential drugs for treating asthma because of their ability to reduce airway inflammation and active force in airway smooth muscle (ASM). Past research has revealed that, besides the effect on
Externí odkaz:
https://doaj.org/article/6d7822d57f754c01bf96c97f8d88c4e4
Autor:
Kathryn N. Seow, Chun Y. Seow
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Muscles convert chemical energy to mechanical work. Mechanical performance of a muscle is often assessed by the muscle’s ability to shorten and generate power over a range of loads or forces, characterized by the force–velocity and force–power
Externí odkaz:
https://doaj.org/article/ddf395b1e77e48a0a71cbfeb7107ee56
Publikováno v:
Cells, Vol 12, Iss 3, p 514 (2023)
Dynamic regulation of myosin filaments is a crucial factor in the ability of airway smooth muscle (ASM) to adapt to a wide length range. Increased stability or robustness of myosin filaments may play a role in the pathophysiology of asthmatic airways
Externí odkaz:
https://doaj.org/article/9f9bff107384430c94b99deaf1367c9f
Autor:
Christopher D. Pascoe, Ma’en Obeidat, Bryna A. Arsenault, Yunlong Nie, Stephanie Warner, Dorota Stefanowicz, Samuel J. Wadsworth, Jeremy A. Hirota, S. Jasemine Yang, Delbert R. Dorscheid, Chris Carlsten, Tillie L. Hackett, Chun Y. Seow, Peter D. Paré
Publikováno v:
BMC Pulmonary Medicine, Vol 17, Iss 1, Pp 1-14 (2017)
Abstract Background Gene expression changes in the structural cells of the airways are thought to play a role in the development of asthma and airway hyperresponsiveness. This includes changes to smooth muscle contractile machinery and epithelial bar
Externí odkaz:
https://doaj.org/article/e66410ac5d12451d8dc6921708813749
Autor:
Chun Y. Seow, Author
This second edition is an updated version of an introductory level textbook intended for students who are interested in understanding the mechanical properties of smooth muscle. Compared with skeletal and cardiac muscles, smooth muscle is the least u
Publikováno v:
Journal of Applied Physiology. 134:152-159
The time course of smooth muscle contraction can be divided into two phases, the initial phase is associated with force development, whereas the sustained phase is associated with force maintenance. Cumulative evidence suggests that the two phases ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf3789ad51b774b038ff6f503bc1e18
https://doi.org/10.1152/japplphysiol.00592.2022
https://doi.org/10.1152/japplphysiol.00592.2022
Autor:
Shou-Jin Dong, Lu Wang, Pasquale Chitano, Dragoş Mihai Vasilescu, Peter D. Paré, Chun Y. Seow
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L882-L889
Lung resistance ( RL) is determined by airway and parenchymal tissue resistance, as well as the degree of heterogeneity in airway constriction. Deep inspirations (DIs) are known to reverse experimentally induced increase in RL, but the mechanism is n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe79e37994b5057d9b02df37dacbab17
https://doi.org/10.1152/ajplung.00033.2022
https://doi.org/10.1152/ajplung.00033.2022
Autor:
Shou-Jin Dong, Lu Wang, Pasquale Chitano, Harvey O. Coxson, Dragoş M. Vasilescu, Peter D. Paré, Chun Y. Seow
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L673-L682
Lung resistance ( RL) and elastance ( EL) can be measured during positive or negative pressure ventilation. Whether the different modes of ventilation produce different RL and EL is still being debated. Although negative pressure ventilation (NPV) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca9295e1b92f4dd8b2d856a65b56e52
https://doi.org/10.1152/ajplung.00464.2021
https://doi.org/10.1152/ajplung.00464.2021