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Melatonin MT1 receptor-induced transcriptional up-regulation of p27Kip1 in prostate cancer antiproliferation is mediated via inhibition of constitutively active nuclear factor kappa B (NF-κB): potential implications on prostate cancer chemoprevention and

Autor: Kwok-Ming Yao, Chun W. Tam, Vincent W.S. Liu, Stephen Y. W. Shiu, Wai Y. Leung

Publikováno v: Journal of Pineal Research. 54:69-79

Our laboratory has recently demonstrated a melatonin MT1 receptor-mediated antiproliferative signaling mechanism in androgen receptor (AR)-positive prostate epithelial cells which involves up-regulation of p27(Kip1) through dual activation of Gα(s)/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff8f653d7f962d00afedc1904c6e79d
https://doi.org/10.1111/j.1600-079x.2012.01026.x

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Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gαs and Gαq proteins

Autor: Chun W. Tam, Stephen Y. W. Shiu, Bo Pang, Kwok-Ming Yao

Publikováno v: Journal of Pineal Research. 49:301-311

Melatonin has been shown to inhibit the proliferation of malignant and transformed human prostate epithelial cells by transcriptional up-regulation of p27(Kip1) expression via MTNR1A receptor-mediated activation of protein kinase A (PKA) and protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0264147da1b2907d8de839de73e8c07b
https://doi.org/10.1111/j.1600-079x.2010.00795.x

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Inhibition of Prostate Cancer Cell Growth by Human Secreted PDZ Domain-Containing Protein 2, a Potential Autocrine Prostate Tumor Suppressor

Autor: Stephen Y. W. Shiu, R. Y. M. Ma, Chun W. Tam, A. S. Cheng, Kwok-Ming Yao

Publikováno v: Endocrinology. 147:5023-5033

A possible role of the PDZ domain-containing protein 2 (PDZD2) in prostate tumorigenesis has been suggested. Besides, PDZD2 is posttranslationally cleaved by a caspasedependent mechanism to form a secreted PDZ domaincontaining protein 2 (sPDZD2) with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89dfb744497dc98d3259c0bcf195e17f
https://doi.org/10.1210/en.2006-0207

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Functional interplay between melatonin receptor-mediated antiproliferative signaling and androgen receptor signaling in human prostate epithelial cells: potential implications for therapeutic strategies against prostate cancer

Autor: Chun W. Tam, Stephen Y. W. Shiu

Publikováno v: Journal of pineal research. 51(3)

Recently, a novel melatonin MT(1) receptor-mediated antiproliferative signaling mechanism involving transcriptional up-regulation of p27(Kip1) due to paralleled stimulation of protein kinase A (PKA) and protein kinase C (PKC), as a result of respecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca077aa4ef8583f2365d9c2b16b075e
https://pubmed.ncbi.nlm.nih.gov/21605164

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Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins

Autor: Stephen Y W, Shiu, Bo, Pang, Chun W, Tam, Kwok-Ming, Yao

Publikováno v: Journal of pineal research. 49(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f91d230a6fd1b9a4b8566c871c090615
https://pubmed.ncbi.nlm.nih.gov/20695976

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Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance

Autor: Bo Pang, Stephen Y. W. Shiu, Kwok-Ming Yao, Chun W. Tam, Vincent W.S. Liu, Kwok W. Chan

Publikováno v: Journal of pineal research. 45(4)

Circannual variation in the human serum levels of prostate-specific antigen, a growth marker of the prostate gland, has been reported recently. The present study was conducted to investigate the role of the photoperiodic hormone melatonin (MLT) and i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51653605b2ace6899e1fa1f06efff64c
https://pubmed.ncbi.nlm.nih.gov/18637986

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Signaling mechanisms of melatonin in antiproliferation of hormone-refractory 22Rv1 human prostate cancer cells: implications for prostate cancer chemoprevention

Autor: Kwok-Ming Yao, Chun W. Tam, Stephen Y. W. Shiu, Chi W. Mo

Publikováno v: Journal of pineal research. 42(2)

There is an unmet clinical demand for safe and effective pharmaceuticals/nutraceuticals for prostate cancer prevention and hormone-refractory prostate cancer treatment. Previous laboratory and human studies of our laboratory demonstrated an associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb12f5df6ab1012634bf1449d7410749
https://pubmed.ncbi.nlm.nih.gov/17286752

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