Immunohistochemical scoring of LAG-3 in conjunction with CD8 in the tumor microenvironment predicts response to immunotherapy in hepatocellular carcinoma.

Autor: Chun Chau Cheung, Lawrence, Justin Seah, Yong Hock, Juntao Fang, Calpatura Orpilla, Nicole Hyacinth, Mai Chan Lau, Chun Jye Lim, Xinru Lim, Li Wen Lee, Justina Nadia, Chun Tatt Lim, Jeffrey, Lim, Sherlly, Qing Cheng, Han Chong Toh, Su Pin Choo, Suat Ying Lee, Jie Xin Lee, Joycelyn, Jin Liu, Kiat Hon Lim, Tony, Tai, David, Yeong, Joe

Publikováno v: Frontiers in Immunology; 2023, p1-15, 15p

Case report: Understanding the impact of persistent tissuelocalization of SARS-CoV-2 on immune response activity via spatial transcriptomic analysis of two cancer patients with COVID-19 co-morbidity.

Autor: Mai Chan Lau, Yang Yi, Goh, Denise, Chun Chau Lawrence Cheung, Tan, Benedict, Chun Tatt Lim, Jeffrey, Ryan Joseph, Craig, Wee, Felicia, Lee, Justina Nadia, Xinru Lim, Chun Jye Lim, Wei Qiang Leow, Jing Yi Lee, Chuan Young Ng, Cedric, Bashiri, Hamed, Peng Chung Cheow, Chun Yip Chan, Ye Xin Koh, Thuan Tong Tan, Kalimuddin, Shirin

Publikováno v: Frontiers in Immunology; 9/12/2022, Vol. 12, p1-10, 10p

PD-L1 expression is an unfavourable prognostic indicator in Asian renal cell carcinomas.

Autor: Joe Yeong, Zitong Zhao, Chun Tatt Lim, Jeffrey, Huihua Li, Aye Aye Thike, Cui Yun Koh, Valerie, Bin Tean Teh, Kanesvaran, Ravindran, Chee Keong Toh, Puay Hoon Tan, Li Yan Khor

Publikováno v: Journal of Clinical Pathology; Aug2020, Vol. 73 Issue 8, p463-469, 7p, 1 Color Photograph, 5 Charts, 2 Graphs

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer.

Autor: Yeong, Joe, Chun Tatt Lim, Jeffrey, Lee, Bernett, Huihua Li, Chong Hui Ong, Clara, Thike, Aye Aye, Wei Hseun Yeap, Yi Yang, Ansel Yi Herh Lim, Kwang Yong Tay, Timothy, Jin Liu, Siew-Cheng Wong, Jinmiao Chen, Hsuen Lim, Elaine, Iqbal, Jabed, Dent, Rebecca, Newell, Evan W., Puay Hoon Tan

Publikováno v: Journal for ImmunoTherapy of Cancer; 12/1/2019, Vol. 7 Issue 1, p1-13, 13p

SC-MEB: spatial clustering with hidden Markov random field using empirical Bayes.

Autor: Yang Y; Program in Health Services & Systems Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Shi X; Academy of Statistics and Interdisciplinary Sciences, East China Normal University, 3663 Zhongshan North Road, 200062, Shanghai, China., Liu W; Program in Health Services & Systems Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Zhou Q; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Chan Lau M; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A*STAR), Street, 138673, Singapore., Chun Tatt Lim J; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A*STAR), Street, 138673, Singapore., Sun L; Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, 8 College Road, 169857, Singapore., Ng CCY, Yeong J; Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (A*STAR), Street, 138673, Singapore.; Department of Anatomical Pathology, Singapore General Hospital, 20 College Road, 169856, Singapore., Liu J; Program in Health Services & Systems Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore.

Publikováno v: Briefings in bioinformatics [Brief Bioinform] 2022 Jan 17; Vol. 23 (1).