Výsledky vyhledávání

Allyl Isothiocyanate Induces Cell Toxicity by Multiple Pathways in Human Breast Cancer Cells

Autor: Yu Cheng Chou, Chun Shu Yu, Fu Shun Yu, Jing Gung Chung, Peng Bo, Jin-Cherng Lien, Chien Chih Yu, Hsu Feng Lu, Ya Yin Chen

Publikováno v: The American Journal of Chinese Medicine. 44:415-437

Isothiocyanates (ITCs) occur in many cruciferous vegetables. These compounds, which have significant anticancer actions, can induce apoptosis in different human cancer cell lines. In the present study, we investigated if allyl isothiocyanate (AITC) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1854a66a41af1cde0b63a12ac94c7f2
https://doi.org/10.1142/s0192415x16500245

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Antitumor effects of deguelin on H460 human lung cancer cellsin vitroandin vivo: Roles of apoptotic cell death and H460 tumor xenografts model

Autor: Chun Shu Yu, Yu Chieh Hsu, Rick Sai-Chuen Wu, Fu Shun Yu, Jo Hua Chiang, Kuang Chi Lai, Te Chun Hsia, Jin-Cherng Lien, Jing Gung Chung

Publikováno v: Environmental Toxicology. 32:84-98

Deguelin, a naturally occurring rotenoid of the flavonoid family, is known to be an Akt inhibitor, to have chemopreventive activities and anti-tumor effect on several cancers. In this study, investigation to elucidate the effect of deguelin on apopto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3035ea1410127f5c5c66a442aa3a39d
https://doi.org/10.1002/tox.22214

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Suppression of the migration and invasion is mediated by triptolide in B16F10 mouse melanoma cells through the NF-kappaB-dependent pathway

Autor: Chun Shu Yu, Shu Jen Chang, Hui Yu Jao, Jing Gung Chung, Bin Chuan Ji, Fu Shun Yu, Kuo Ching Liu, Da Tian Bau, Ching Lung Liao

Publikováno v: Environmental Toxicology. 31:1974-1984

Melanoma cancer is one of the major causes of death in humans worldwide. Triptolide is one of the active components of Tripterygium wilfordii Hook F, and has biological activities including induced cell cycle arrest and induction of apoptosis but its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b44b0fe78f8d19421ef027fec95a3ea8
https://doi.org/10.1002/tox.22198

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Tetrandrine induces apoptosis Via caspase-8, -9, and -3 and poly (ADP ribose) polymerase dependent pathways and autophagy through beclin-1/ LC3-I, II signaling pathways in human oral cancer HSC-3 cells

Autor: Fu Shun Yu, Jiun Long Yang, Shu Jen Chang, Jing Gung Chung, Meng Wei Lin, Chun Shu Yu, Jaw-Chyun Chen, Hsu Feng Lu

Publikováno v: Environmental Toxicology. 31:395-406

Tetrandrine is a bisbenzylisoquinoline alkaloid that was found in the Radix Stephania tetrandra S Moore. It had been reported to induce cytotoxic effects on many human cancer cells. In this study, we investigated the cytotoxic effects of tetrandrine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::595387d8d6165016264458f1464a32a8
https://doi.org/10.1002/tox.22053

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Citosol (thiamylal sodium) triggers apoptosis and affects gene expressions of murine leukemia RAW 264.7 cells

Autor: Fu Shin Chueh, Hui Ying Huang, Jing Gung Chung, Jai Sing Yang, Jing Pin Lin, R. C. Wu, K. C. Liu, Chun Shu Yu, Siu Wan Ip

Publikováno v: Human & Experimental Toxicology. 31:771-779

Citosol (thiamylal sodium) is one of generally used anesthetic–sedative agents for clinical patients, and it has not been reported to show induction of cytotoxic effects in cancer cells, especially in mice leukemia RAW 264.7 cells in vitro. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e23ec749031e5f9405eff2351b27dd2
https://doi.org/10.1177/0960327111429137

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Chrysophanol-induced cell death (necrosis) in human lung cancer A549 cells is mediated through increasing reactive oxygen species and decreasing the level of mitochondrial membrane potential

Autor: Chun Shu Yu, Su Yin Chiang, Po-Yuan Chen, Jing Gung Chung, Shin Hwar Wu, Jai Sing Yang, Hsu Feng Lu, Siu Wan Ip, Hui Ying Huang, Chien Hang Ni, Jaung Geng Lin

Publikováno v: Environmental Toxicology. 29:740-749

Chrysophanol (1,8-dihydroxy-3-methylanthraquinone) is one of the anthraquinone compounds, and it has been shown to induce cell death in different types of cancer cells. The effects of chrysophanol on human lung cancer cell death have not been well st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f0b0b162da0f787c70b729231d62e70
https://doi.org/10.1002/tox.21801

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Benzyl Isothiocyanate (BITC) Induces G2/M Phase Arrest and Apoptosis in Human Melanoma A375.S2 Cells through Reactive Oxygen Species (ROS) and both Mitochondria-Dependent and Death Receptor-Mediated Multiple Signaling Pathways

Autor: Su Hua Huang, Liu Wei Wu, Chun Shu Yu, W. Gibson Wood, An Cheng Huang, Chien Chih Yu, Yi Ping Huang, Jing Gung Chung, Jai Sing Yang, Jin-Cherng Lien, Yu Ping Hsiao, Jen Hung Yang

Publikováno v: Journal of Agricultural and Food Chemistry. 60:665-675

Benzyl isothiocyanates (BITC), a member of the isothiocyanate (ITC) family, inhibits cell growth and induces apoptosis in many types of human cancer cell lines. The present study investigated mechanisms underlying BITC-induced apoptosis in A375.S2 hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98ddfbccc7ce7208adc36937ab3df67
https://doi.org/10.1021/jf204193v

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Bee venom induces apoptosis through intracellular Ca2+-modulated intrinsic death pathway in human bladder cancer cells

Autor: Heng Chien Ho, Hui Ying Huang, Siu Wan Ip, Fu Shin Chueh, Tung Yuan Lai, Po-Yuan Chen, Chun Shu Yu, Yung Lin Chu, Jing Gung Chung, Jai Sing Yang

Publikováno v: International Journal of Urology. 19:61-70

Objectives: To focus on bee venom-induced apoptosis in human bladder cancer TSGH-8301 cells and to investigate its signaling pathway to ascertain whether intracellular calcium iron (Ca2+) is involved in this effect. Methods: Bee venom-induced cytotox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a80dcb0f07352cb6aa238f2986d3d1d
https://doi.org/10.1111/j.1442-2042.2011.02876.x

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Induction of apoptotic death by curcumin in human tongue squamous cell carcinoma SCC-4 cells is mediated through endoplasmic reticulum stress and mitochondria-dependent pathways

Autor: Chao Lin Kuo, Shan Ying Wu, Jai Sing Yang, Chun Shu Yu, Heng Chien Ho, Hsiung Kwang Chung, Siu Wan Ip, Shang Ming Chiou, Chien Chih Yu, Jing Gung Chung, Zen Pin Lin

Publikováno v: Cell Biochemistry and Function. 29:641-650

Curcumin from the rhizome of the Curcuma longa plant has been noted for its chemo-preventative and chemo-therapy activities, and it inhibits the growth of many types of human cancer cell lines. In this study, the mechanisms of cell death involved in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f781a0e4e03b5c3f558131cfdea01f9a
https://doi.org/10.1002/cbf.1800

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Safrole suppresses murine myelomonocytic leukemia WEHI-3 cellsin vivo, and stimulates macrophage phagocytosis and natural killer cell cytotoxicity in leukemic mice

Autor: Chun Shu Yu, Jo Hua Chiang, Hsiung Kwang Chung, Jai Sing Yang, Chih-Chung Wu, Heng Chien Ho, Jing Gung Chung, Chi Cheng Lu, Chien Chih Yu, Fu Shun Yu

Publikováno v: Environmental Toxicology. 28:601-608

Many anticancer drugs are obtained from phytochemicals and natural products. However, some phytochemicals have mutagenic effects. Safrole, a component of Piper betle inflorescence, has been reported to be a carcinogen. We have previously reported tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c52a52b7663313e3194fadd50c323f97
https://doi.org/10.1002/tox.20756

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