Human leucocyte antigens profiling in Malay female patients with systemic lupus erythematosus: are we the same or different?

Autor: Chun Lai Too, Malarvili Selvaraja, Lay Kim Tan, Bee Tee Koay, Maha Abdullah, Anim Md Shah, Masita Arip, Syafinaz Amin-Nordin

Publikováno v: Lupus Science and Medicine, Vol 9, Iss 1 (2022)

Objective SLE is a heterogeneous autoimmune disease, in terms of clinical presentation, incidence and severity across diverse ethnic populations. We investigated the human leucocyte antigens (HLA) profile (ie, HLA-A, HLA-B and HLA-C, HLA-DRB1, HLA-DQ

Externí odkaz: https://doaj.org/article/d5018250ccdf4fa88cf5b8a7c2c4e438

Dimensionality reduction reveals fine-scale structure in the Japanese population with consequences for polygenic risk prediction

Autor: Saori Sakaue, Jun Hirata, Masahiro Kanai, Ken Suzuki, Masato Akiyama, Chun Lai Too, Thurayya Arayssi, Mohammed Hammoudeh, Samar Al Emadi, Basel K. Masri, Hussein Halabi, Humeira Badsha, Imad W. Uthman, Richa Saxena, Leonid Padyukov, Makoto Hirata, Koichi Matsuda, Yoshinori Murakami, Yoichiro Kamatani, Yukinori Okada

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)

Population structure, even subtle differences within seemingly homogenous populations, can have an impact on the accuracy of polygenic prediction. Here, Sakaue et al. use dimensionality reduction methods to reveal fine-scale structure in the Biobank

Externí odkaz: https://doaj.org/article/c4f4b797ca974d86bfaca12d2007301f

Correction: A Replication Study Confirms the Association of Dendritic Cell Immunoreceptor (DCIR) Polymorphisms with ACPA - Negative RA in a Large Asian Cohort.

Autor: Jianping Guo, Xinyu Wu, Chun Lai Too, Fangrui Yin, Xiaolan Lu, Jing He, Ru Li, Xu Liu, Shahnaz Murad, Leonid Padyukov, Zhanguo Li

Publikováno v: PLoS ONE, Vol 7, Iss 10 (2012)

[This corrects the article DOI: 10.1371/journal.pone.0041228.].

Externí odkaz: https://doaj.org/article/9b39a00a662244aba109e48c861edd89

Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis

Autor: Kazuyoshi, Ishigaki, Saori, Sakaue, Chikashi, Terao, Yang, Luo, Kyuto, Sonehara, Kensuke, Yamaguchi, Tiffany, Amariuta, Chun Lai, Too, Vincent A, Laufer, Ian C, Scott, Sebastien, Viatte, Meiko, Takahashi, Koichiro, Ohmura, Akira, Murasawa, Motomu, Hashimoto, Hiromu, Ito, Mohammed, Hammoudeh, Samar Al, Emadi, Basel K, Masri, Hussein, Halabi, Humeira, Badsha, Imad W, Uthman, Xin, Wu, Li, Lin, Ting, Li, Darren, Plant, Anne, Barton, Gisela, Orozco, Suzanne M M, Verstappen, John, Bowes, Alexander J, MacGregor, Suguru, Honda, Masaru, Koido, Kohei, Tomizuka, Yoichiro, Kamatani, Hiroaki, Tanaka, Eiichi, Tanaka, Akari, Suzuki, Yuichi, Maeda, Kenichi, Yamamoto, Satoru, Miyawaki, Gang, Xie, Jinyi, Zhang, Christopher I, Amos, Edward, Keystone, Gertjan, Wolbink, Irene, van der Horst-Bruinsma, Jing, Cui, Katherine P, Liao, Robert J, Carroll, Hye-Soon, Lee, So-Young, Bang, Katherine A, Siminovitch, Niek, de Vries, Lars, Alfredsson, Solbritt, Rantapää-Dahlqvist, Elizabeth W, Karlson, Sang-Cheol, Bae, Robert P, Kimberly, Jeffrey C, Edberg, Xavier, Mariette, Tom, Huizinga, Philippe, Dieudé, Matthias, Schneider, Martin, Kerick, Joshua C, Denny, Koichi, Matsuda, Keitaro, Matsuo, Tsuneyo, Mimori, Fumihiko, Matsuda, Keishi, Fujio, Yoshiya, Tanaka, Atsushi, Kumanogoh, Matthew, Traylor, Cathryn M, Lewis, Stephen, Eyre, Huji, Xu, Richa, Saxena, Thurayya, Arayssi, Yuta, Kochi, Katsunori, Ikari, Masayoshi, Harigai, Peter K, Gregersen, Kazuhiko, Yamamoto, S, Louis Bridges, Leonid, Padyukov, Javier, Martin, Lars, Klareskog, Yukinori, Okada, Soumya, Raychaudhuri

Publikováno v: Nature Genetics, 54, 1640-1651
The Biobank Japan Project 2022, ' Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis ', Nature Genetics, vol. 54, no. 11, pp. 1640-1651 . https://doi.org/10.1038/s41588-022-01213-w
Nature genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54(11), 1640-+. NATURE PORTFOLIO
Nature Genetics, 54(11), 1640-1651. Nature Publishing Group
Nature Genetics, 54, 11, pp. 1640-1651
Nat Genet

Multi-ancestry genome-wide association analyses identify 124 risk loci for rheumatoid arthritis, of which 34 are novel. A polygenic risk score based on multi-ancestry data showed comparable performance between populations of European and East Asian a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e48733cf2e8205acbde830a39b0265
https://doi.org/10.1038/s41588-022-01213-w

The spectrum of association in HLA region with rheumatoid arthritis in a diverse Asian population: evidence from the MyEIRA case-control study

Autor: Hussein Heselynn, Lars Alfredsson, Suk Chyn Gun, Mohamed Said Mohd-Shahrir, Mageswaran Eashwary, S. Wahinuddin, Leonid Padyukov, Shahril Nor-Shuhaila, Othman Muhaini, Lars Klareskog, Lay Kim Tan, Mohd Mokhtar Ainon, Rosman Azmillah, Lina-Marcela Diaz-Gallo, Murad Shahnaz, Ing Soo Lau, Chun Lai Too

Publikováno v: Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Arthritis Research & Therapy

Background Fine-mapping of human leukocyte antigen (HLA) region for rheumatoid arthritis (RA) risk factors has identified several HLA alleles and its corresponding amino acid residues as independent signals (i.e., HLA-A, HLA-B, HLA-DPB1, and HLA-DQA1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edcb6defcfe0d8261a37970e93fb166b
https://doaj.org/article/4db19290c04946a5a696b84802f12837