Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Chun Kiu Hui"'
Autor:
Rosella Abeti, Mittal Jasoliya, Sahar Al-Mahdawi, Mark Pook, Cristina Gonzalez-Robles, Chun Kiu Hui, Gino Cortopassi, Paola Giunti
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Friedreich’s ataxia (FA) is an inherited multisystemic neuro- and cardio-degenerative disorder. Seventy-four clinical trials are listed for FA (including past and present), but none are considered FDA/EMA-approved therapy. To date, FA therapeutic s
Externí odkaz:
https://doaj.org/article/dda4674985d74004abe28af246f53445
Publikováno v:
Human molecular genetics, vol 29, iss 24
Hum Mol Genet
Hum Mol Genet
Previously we showed that dimethyl fumarate (DMF) dose-dependently increased mitochondrial gene expression and function in cells and might be considered as a therapeutic for inherited mitochondrial disease, including Friedreich’s ataxia (FA). Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a6f014f13e08119c0df0bb0060caf4
https://escholarship.org/uc/item/14k4k58g
https://escholarship.org/uc/item/14k4k58g
Publikováno v:
Pharmacological Research. 137:89-103
When insulin binds insulin receptor, IRS1 signaling is stimulated to trigger the maximal insulin response. p52Shc protein competes directly with IRS1, thus damping and diverting maximal insulin response. Genetic reduction of p52Shc minimizes competit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48a5e9fe6794e287703f35b659df1a4
https://doi.org/10.1016/j.phrs.2018.09.024
https://doi.org/10.1016/j.phrs.2018.09.024
Autor:
Xiao Song Jiang, James L. Graham, Chun Kiu Hui, Maurizio Prato, Chase Garcia, Sidney M. Hecht, Omar M. Khdour, Cristian Rosso, Giacomo Filippini, Gino A Cortopassi, David M. Fash, Alexey Tomilov, Peter J. Havel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 132, Iss, Pp 110823-(2020)
There has been little innovation in identifying novel insulin sensitizers. Metformin, developed in the 1920s, is still used first for most Type 2 diabetes patients. Mice with genetic reduction of p52Shc protein have improved insulin sensitivity and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9e6a2c73063cd7f8aae27f3ab69b68
https://doi.org/10.1016/j.biopha.2020.110823
https://doi.org/10.1016/j.biopha.2020.110823