Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Chun J. Ye"'
Autor:
Roy Oelen, Dylan H. de Vries, Harm Brugge, M. Grace Gordon, Martijn Vochteloo, single-cell eQTLGen consortium, BIOS Consortium, Chun J. Ye, Harm-Jan Westra, Lude Franke, Monique G. P. van der Wijst
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Not just differential gene expression but also differential gene regulation in immune cells account for individual differences in the immune response. Authors show here by single-cell RNA-sequencing of peripheral blood mononuclear cells from a large
Externí odkaz:
https://doaj.org/article/a0900e4955844d238d355bfc06a2a975
Autor:
Jhoanne L. Bautista, Nathan T. Cramer, Corey N. Miller, Jessica Chavez, David I. Berrios, Lauren E. Byrnes, Joe Germino, Vasilis Ntranos, Julie B. Sneddon, Trevor D. Burt, James M. Gardner, Chun J. Ye, Mark S. Anderson, Audrey V. Parent
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The thymus supports T cell immunity by providing the environment for thymocyte differentiation. Here the authors profile human thymic stroma at the single cell level, identifying ionocytes as a new medullary population and defining tissue specific an
Externí odkaz:
https://doaj.org/article/3c3cfdba2df144faad4bed7327a4f1bd
Autor:
Christopher S. McGinnis, David A. Siegel, Guorui Xie, George Hartoularos, Mars Stone, Chun J. Ye, Zev J. Gartner, Nadia R. Roan, Sulggi A. Lee
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-11 (2021)
Abstract Background Single-cell RNA sequencing (scRNA-seq) provides high-dimensional measurements of transcript counts in individual cells. However, high assay costs and artifacts associated with analyzing samples across multiple sequencing runs limi
Externí odkaz:
https://doaj.org/article/bea83cbdb3b44163b4655e3d340c2253
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The increasing accessibility of single cell RNA sequencing demands tools that enable data visualization and interpretation. Here, the authors introduce Vision, a flexible annotation tool that operates directly on the manifold of cell-cell similarity
Externí odkaz:
https://doaj.org/article/805bad0f014e42d38fb388a963346447
Autor:
Lauren E. Byrnes, Daniel M. Wong, Meena Subramaniam, Nathaniel P. Meyer, Caroline L. Gilchrist, Sarah M. Knox, Aaron D. Tward, Chun J. Ye, Julie B. Sneddon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Coordinated proliferation and differentiation of diverse cell populations drive pancreatic epithelial and mesenchymal development. Here, the authors profile cell type dynamics in the developing mouse pancreas using single-cell RNA sequencing, identif
Externí odkaz:
https://doaj.org/article/9908253a395045fca4eafe9adba9fcf4
Autor:
Levi J. Rupp, Kathrin Schumann, Kole T. Roybal, Rachel E. Gate, Chun J. Ye, Wendell A. Lim, Alexander Marson
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Immunotherapies with chimeric antigen receptor (CAR) T cells and checkpoint inhibitors (including antibodies that antagonize programmed cell death protein 1 [PD-1]) have both opened new avenues for cancer treatment, but the clinical potentia
Externí odkaz:
https://doaj.org/article/665f79f789f343fe9fc1e3bc666749d5
Autor:
Charalambos Andreadis, Frank McCormick, Gabriela K. Fragiadakis, Pamela N. Munster, David P. Carbone, Chun J. Ye, Vivian Weinberg, Michael Flanders, Emma McMahon, Karin M. Gaensler, Peter H. Sayre, Thomas G. Martin, Lloyd E. Damon, Rebecca Olin, Gabriel N. Mannis, Matthew Settles, Aaron C. Logan, Tommy Jiang, Blythe Durbin-Johnson, Arjun A. Rao, Gregory K. Behbehani, Ravi K. Patel, Bradley W. Blaser, Victoria E. Wang
Supplementary Data from Inhibition of MET Signaling with Ficlatuzumab in Combination with Chemotherapy in Refractory AML: Clinical Outcomes and High-Dimensional Analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e9274c477d2ab2f5535764c6f7ffb71
https://doi.org/10.1158/2643-3230.22543692
https://doi.org/10.1158/2643-3230.22543692
Autor:
Charalambos Andreadis, Frank McCormick, Gabriela K. Fragiadakis, Pamela N. Munster, David P. Carbone, Chun J. Ye, Vivian Weinberg, Michael Flanders, Emma McMahon, Karin M. Gaensler, Peter H. Sayre, Thomas G. Martin, Lloyd E. Damon, Rebecca Olin, Gabriel N. Mannis, Matthew Settles, Aaron C. Logan, Tommy Jiang, Blythe Durbin-Johnson, Arjun A. Rao, Gregory K. Behbehani, Ravi K. Patel, Bradley W. Blaser, Victoria E. Wang
Acute myeloid leukemia (AML) patients refractory to induction therapy or relapsed within 1 year have poor outcomes. Autocrine production of hepatocyte growth factor by myeloid blasts drives leukemogenesis in preclinical models. A phase Ib trial evalu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c6723e49382eda7eadaaae9301736b6
https://doi.org/10.1158/2643-3230.c.6550365.v1
https://doi.org/10.1158/2643-3230.c.6550365.v1
Autor:
Marcos Assis Nascimento, Sean Biagiotti, Vicente Herranz-Pérez, Raymund Bueno, Chun J. Ye, Taylor Abel, Juan S. Rubio-Moll, Jose Manuel Garcia-Verdugo, Eric J. Huang, Arturo Alvarez-Buylla, Shawn F. Sorrells
The entorhinal cortex (EC) is a highly-interconnected hub for multisensory integration and memory processing1–3, containing diverse neuronal subtypes4,5 including subpopulations that are uniquely spatially-tuned6,7. Although many spatial and memory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9717c10c5cf1c4d0f0874f8c3f99928
https://doi.org/10.1101/2022.03.19.484996
https://doi.org/10.1101/2022.03.19.484996
Autor:
Roy, Oelen, Dylan H, de Vries, Harm, Brugge, M Grace, Gordon, Martijn, Vochteloo, Chun J, Ye, Harm-Jan, Westra, Lude, Franke, Monique G P, van der Wijst
Publikováno v:
Nature communications. 13(1)
The host's gene expression and gene regulatory response to pathogen exposure can be influenced by a combination of the host's genetic background, the type of and exposure time to pathogens. Here we provide a detailed dissection of this using single-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::81a4355a6281e4e9f9c7207bea4dbdbf
https://pubmed.ncbi.nlm.nih.gov/35672358
https://pubmed.ncbi.nlm.nih.gov/35672358