Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Chun Hui Bu"'
Autor:
Lucienne Chatenoud, Cindy Marquet, Fabrice Valette, Lindsay Scott, Jiexia Quan, Chun Hui Bu, Sara Hildebrand, Eva Marie Y. Moresco, Jean-François Bach, Bruce Beutler
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Genetic association studies of type 1 diabetes (T1D) in humans, and in congenic non-obese diabetic (NOD) mice harboring DNA segments from T1D-resistant mice, face the challenge of assigning causation to specific gene variants among many within loci t
Externí odkaz:
https://doaj.org/article/8f1693213fcf42edb01f31ae9b26c371
Autor:
Tao Wang, Chun Hui Bu, Sara Hildebrand, Gaoxiang Jia, Owen M. Siggs, Stephen Lyon, David Pratt, Lindsay Scott, Jamie Russell, Sara Ludwig, Anne R. Murray, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Programs such as PolyPhen-2 predict the relative severity of damage by missense mutations. Here, Wang et al estimate probabilities that putative null or missense alleles would reduce protein function to cause detectable phenotype by analyzing data fr
Externí odkaz:
https://doaj.org/article/151023422b8a43e995162f958a228591
Autor:
William McAlpine, Kuan-wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer, Bruce Beutler
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of
Externí odkaz:
https://doaj.org/article/e7d13b984c284195b19b267544941ddb
Autor:
Xue Zhong, Moresco, James J., SoRelle, Jeffrey A., Ran Song, Yiao Jiang, Nguyen, Mylinh T., Jianhui Wang, Chun Hui Bu, Moresco, Eva Marie Y., Beutler, Bruce, Jin Huk Choi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 7/30/2024, Vol. 121 Issue 31, p1-8, 22p
Autor:
Jin Huk Choi, Bruce Beutler, Mihwa Choi, Lindsay Scott, Xiaowei Zhan, Jianhui Wang, Xiaoming Zhan, Zhe Chen, Jeffrey A. SoRelle, Jamie Russell, Sara Ludwig, Sara Hildebrand, Xiaohong Li, Darui Xu, Xue Zhong, Eva Marie Y. Moresco, Chun Hui Bu, Miao Tang, Tao Wang, Tao Yue, Kuan Wen Wang
Publikováno v:
Allergy
Background Atopy, the overall tendency to become sensitized to an allergen, is heritable but seldom ascribed to mutations within specific genes. Atopic individuals develop abnormally elevated IgE responses to immunization with potential allergens. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be111f4d9017c52804094f63ea19840
https://doi.org/10.1111/all.14564
https://doi.org/10.1111/all.14564
Autor:
Fabrice Valette, Pere Santamaria, Jean-François Bach, Claudio Scazzocchio, Sophie Candon, Sebastien Lemoine, Sara Hildebrand, Peipei Hu, Bruce Beutler, Sylvaine You, Francina Langa-Vives, Stephen Aplin Lyon, Anne-Perrine Foray, Eva Marie Y. Moresco, Chun Hui Bu, Lucienne Chatenoud, Coralie Pecquet, Darui Xu, Cindy Marquet, Michael Dumas, Lindsay Scott, Tao Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2112032118. ⟨10.1073/pnas.2112032118⟩
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), pp.e2112032118. ⟨10.1073/pnas.2112032118⟩
Proc Natl Acad Sci U S A
International audience; Significance: The vast majority of autoimmune diseases are polygenic, and causal loci uncovered by genetic-mapping studies explain only a minority of the heritable contribution to trait variation. Multiple explanations for thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3ba665602db471fa72ce8128e19ff67
https://doi.org/10.1073/pnas.2112032118
https://doi.org/10.1073/pnas.2112032118
Autor:
Zhao Zhang, Yiao Jiang, Lijing Su, Sara Ludwig, Xuechun Zhang, Miao Tang, Xiaohong Li, Priscilla Anderton, Xiaoming Zhan, Mihwa Choi, Jamie Russell, Chun-Hui Bu, Stephen Lyon, Darui Xu, Sara Hildebrand, Lindsay Scott, Jiexia Quan, Rochelle Simpson, Qihua Sun, Baifang Qin, Tiffany Collie, Meron Tadesse, Eva Marie Y. Moresco, Bruce Beutler
Publikováno v:
Cell Metabolism. 34:1860-1874.e4
Using random germline mutagenesis in mice, we identified a viable hypomorphic allele (boh) of the transcription-factor-encoding gene Ovol2 that resulted in obesity, which initially developed with normal food intake and physical activity but decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67058d1e661d6ad190ccaa01cb2cca8
https://doi.org/10.1016/j.cmet.2022.09.018
https://doi.org/10.1016/j.cmet.2022.09.018
Autor:
Sara Schneider, Xue Zhong, Emre E. Turer, Jeffrey A. SoRelle, Sydney Cooper, Miao Tang, Jamie Russell, Stephen Aplin Lyon, Xiaoming Zhan, Zhao Zhang, Priscilla Anderton, Katie Keller, Andrew Sakla, Jennifer Cardin, Bruce Beutler, Lei Sun, Jiexia Quan, Roxana Farokhnia, Sara Mazal, Carol Wise, Duanwu Zhang, Lijing Su, Jin Huk Choi, Qihua Sun, Baifang Qin, Braden Hayse, Hexin Shi, Brandon Nguyen, Xiaohong Li, Hannah Coco, Andrew Wadley, Darui Xu, Meron Tadesse, William McAlpine, Eva Marie Y. Moresco, Tao Yue, Gabrielle Coolbaugh, Ying Wang, Chun Hui Bu, Sara Hildebrand, Evan Nair-Gill, Rochelle Simpson, Elena Mahrt, Aijie Liu, Jonathan J. Rios, Jianhui Wang, Takuma Misawa, Edward Rodriguez, Sara Ludwig, Mihwa Choi, Lindsay Scott, Amanda Press, Dawson Medler, Tiffany Collie, Kuan Wen Wang
Publikováno v:
Proc Natl Acad Sci U S A
Forward genetic studies use meiotic mapping to adduce evidence that a particular mutation, normally induced by a germline mutagen, is causative of a particular phenotype. Particularly in small pedigrees, cosegregation of multiple mutations, occasiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b995edcfd1d9fa347e576eac7252985e
https://doi.org/10.1073/pnas.2106786118
https://doi.org/10.1073/pnas.2106786118
Autor:
Chun Hui Bu, Bruce Beutler, Fabrice Valette, Sophie Candon, Sara Hildebrand, Sebastien Lemoine, Jean-François Bach, Anne-Perrine Foray, Stephen Aplin Lyon, Darui Xu, Eva Marie Y. Moresco, Francina Langa-Vives, Coralie Pecquet, Lucienne Chatenoud, Pere Santamaria, Tao Wang, Michael Dumas, Cindy Marquet, Claudio Scazzocchio, Peipei Hu, Lindsay Scott
Here we report the isolation by selective breeding of two sublines of Non-Obese Diabetic (NOD) mice exhibiting a significant difference in the incidence of autoimmune type 1 diabetes (T1D). Whole genome sequencing of the NOD/NckH (high T1D incidence)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdbd7c5c6774c9e82da1ab67ae0df318
https://doi.org/10.1101/2020.12.30.424747
https://doi.org/10.1101/2020.12.30.424747
Autor:
Priscilla Anderton, Stephen Aplin Lyon, Zhao Zhang, Takuma Misawa, Meron Tadesse, Duanwu Zhang, Tao Yue, Miao Tang, Lindsay Scott, Jeffrey A. SoRelle, Hexin Shi, Jennifer Cardin, Sydney Cooper, Jiexia Quan, Jin Huk Choi, Nathan Stewart, Emre E. Turer, Chun Hui Bu, Sara Schneider, Xue Zhong, Dawson Medler, Katie Keller, Alexyss Johnson, Brandon Nguyen, Darui Xu, Braden Hayse, Bruce Beutler, Lei Sun, Jianhui Wang, Evan Nair-Gill, Edward Rodriguez, Aijie Liu, Sara Hildebrand, Qihua Sun, Andrew Wadley, Sara Mazal, Xiaohong Li, Gabrielle Coolbaugh, Ying Wang, Rochelle Simpson, Eva Marie Y. Moresco, John Santoyo, Baifang Qin, Roxana Farokhnia, Andrew Sakla, Amy Bronikowski, Hannah Coco
When applied to immunity, forward genetic studies use meiotic mapping to provide strong statistical evidence that a particular mutation is causative of a particular immune phenotype. Notwithstanding this, co-segregation of multiple mutations, occasio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4269fd5529c6dce400ad68cea677a9ea
https://doi.org/10.1101/2020.11.07.371914
https://doi.org/10.1101/2020.11.07.371914