Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Chun C. Fan"'
Autor:
Lasse Bang, Shahram Bahrami, Guy Hindley, Olav B. Smeland, Linn Rødevand, Piotr P. Jaholkowski, Alexey Shadrin, Kevin S. O’ Connell, Oleksandr Frei, Aihua Lin, Zillur Rahman, Weiqiu Cheng, Nadine Parker, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Cynthia M. Bulik, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Anorexia nervosa (AN) is a heritable eating disorder (50–60%) with an array of commonly comorbid psychiatric disorders and related traits. Although significant genetic correlations between AN and psychiatric disorders and related traits ha
Externí odkaz:
https://doaj.org/article/1504dcdb9170486786ab8df09684f946
Autor:
Guy Hindley, Shahram Bahrami, Nils Eiel Steen, Kevin S. O’Connell, Oleksandr Frei, Alexey Shadrin, Francesco Bettella, Linn Rødevand, Chun C. Fan, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are overrepresented in both disorders and associated with poor health outco
Externí odkaz:
https://doaj.org/article/c366b87c22cf4cc282473524c3c42ec0
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-10 (2020)
Abstract In the clinical diagnosis of dementia with Lewy bodies, distinction from Alzheimer’s disease is suboptimal and complicated by shared genetic risk factors and frequent co-pathology. In the present study we tested the ability of polygenic sc
Externí odkaz:
https://doaj.org/article/bf8281643420441198e5a2faa9d826ef
Autor:
Alexey A. Shadrin, Tobias Kaufmann, Dennis van der Meer, Clare E. Palmer, Carolina Makowski, Robert Loughnan, Terry L. Jernigan, Tyler M. Seibert, Donald J Hagler, Olav B. Smeland, Ehsan Motazedi, Yunhan Chu, Aihua Lin, Weiqiu Cheng, Guy Hindley, Wesley K. Thompson, Chun C. Fan, Dominic Holland, Lars T. Westlye, Oleksandr Frei, Ole A. Andreassen, Anders M. Dale
Publikováno v:
NeuroImage, Vol 244, Iss , Pp 118603- (2021)
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome
Externí odkaz:
https://doaj.org/article/00840c2b0f414737b79b926d62cb639e
Autor:
Dora Cserbik, Jiu-Chiuan Chen, Rob McConnell, Kiros Berhane, Elizabeth R. Sowell, Joel Schwartz, Daniel A. Hackman, Eric Kan, Chun C. Fan, Megan M. Herting
Publikováno v:
Environment International, Vol 143, Iss , Pp 105933- (2020)
Background: Emerging findings have increased concern that exposure to fine particulate matter air pollution (aerodynamic diameter ≤ 2.5 μm; PM2.5) may be neurotoxic, even at lower levels of exposure. Yet, additional studies are needed to determine
Externí odkaz:
https://doaj.org/article/8c39522b97544567b44c51f87dbab42c
Autor:
Ehsan Motazedi, Weiqiu Cheng, Jesper Q. Thomassen, Oleksandr Frei, Arvid Rongve, Lavinia Athanasiu, Shahram Bahrami, Alexey Shadrin, Ingun Ulstein, Eystein Stordal, Anne Brækhus, Ingvild Saltvedt, Sigrid B. Sando, Kevin S. O’Connell, Guy Hindley, Dennis van der Meer, Sverre Bergh, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Geir Bråthen, Lasse Pihlstrøm, Srdjan Djurovic, Ruth Frikke-Schmidt, Tormod Fladby, Dag Aarsland, Geir Selbæk, Tyler M. Seibert, Anders M. Dale, Chun C. Fan, Ole A. Andreassen
Publikováno v:
J Alzheimers Dis
Journal of Alzheimer's Disease, 88(4), 1533-1544. IOS Press
Journal of Alzheimer's Disease, 88(4), 1533-1544. IOS Press
BACKGROUND: Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the m
Autor:
Aihua Lin, Alexey Shadrin, Dennis van der Meer, Guy Hindley, Weiqiu Cheng, Ida Elken Sønderby, Shahram Bahrami, Kevin S O’Connell, Zillur Rahman, Nadine Parker, Olav B Smeland, Chun C. Fan, Dominic Holland, Anders M Dale, Ole A Andreassen, Oleksandr Frei
MotivationGenome-wide association studies (GWAS) have been successful in identifying genetic variants associated with a particular phenotype. However, many complex phenotypes are influenced by multiple genetic variants with small effects. Detecting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c8be4ea3a28f4d92eef20b63b1bfd26
https://doi.org/10.1101/2022.08.18.504383
https://doi.org/10.1101/2022.08.18.504383
Autor:
Romain Icick, Alexey Shadrin, Børge Holen, Naz Karadag, Aihua Lin, Guy Hindley, Kevin O’Connell, Oleksandr Frei, Shahram Bahrami, Margrethe Collier Høegh, Weiqiu Cheng, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Trine Vik Lagerberg, Olav B. Smeland, Ole A. Andreassen
Alcohol use disorder (AUD) is a pervasive and devastating mental illness with high comorbidity rates with other mental disorders. We aimed to characterize the sharedvs. unique polygenicity of AUD, alcohol consumption (AC) and mood instability (MOOD),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9148fd8447e447ed0bcf6d54a52a856
https://doi.org/10.1101/2022.03.08.22271329
https://doi.org/10.1101/2022.03.08.22271329
Autor:
Guy Hindley, Alexey Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Chun C Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Personality and cognition are heritable mental traits, and their genetic determinants may be distributed across interconnected brain functions. However, previous studies have employed univariate approaches which reduce complex traits to summary measu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8110977d552e2f77912e3dc001bea018
https://doi.org/10.1101/2022.02.28.481967
https://doi.org/10.1101/2022.02.28.481967
Autor:
Guy Hindley, Kevin S. O'Connell, Zillur Rahman, Oleksandr Frei, Shahram Bahrami, Alexey Shadrin, Margrethe C. Høegh, Weiqiu Cheng, Naz Karadag, Aihua Lin, Linn Rødevand, Chun C. Fan, Srdjan Djurovic, Trine V. Lagerberg, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Publikováno v:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Recent genome-wide association studies of mood instability (MOOD) have found significant positive genetic correlation with major depression (DEP) and weak correlations with other psychiatric disorders. We investigated the polygenic overlap between MO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e151a3b6dfa4f1b53d67b71a8b0d51c5
http://hdl.handle.net/10852/98032
http://hdl.handle.net/10852/98032