Dysregulation of mitochondrial dynamics mediated aortic perivascular adipose tissue-associated vascular reactivity impairment under excessive fructose intake

Autor: Kay L. H. Wu, Chih-Wei Wu, Lee-Wei Chen, Hsiao-Huang Chang, Ching-Li Cheng, Cai-Yi Wu, Yu-Chi Lee, I-Chun Chen, Chun-Ying Hung, Wen-Chung Liu

Publikováno v: Nutrition & Metabolism, Vol 21, Iss 1, Pp 1-15 (2024)

Abstract Excessive fructose intake presents the major risk factor for metabolic cardiovascular disease. Perivascular adipose tissue (PVAT) is a metabolic tissue and possesses a paracrine function in regulating aortic reactivity. However, whether and

Externí odkaz: https://doaj.org/article/15ae81c2905841abbfbd805823ae504e

Anti-neuroinflammation ameliorates systemic inflammation-induced mitochondrial DNA impairment in the nucleus of the solitary tract and cardiovascular reflex dysfunction

Autor: Mu-Hui Fu, I-Chun Chen, Chou-Hwei Lee, Chih-Wei Wu, Yu-Chi Lee, Yu Chih Kung, Chun-Ying Hung, Kay L. H. Wu

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Decreased heart rate variability (HRV) leads to cardiovascular diseases and increased mortality in clinical studies. However, the underlying mechanisms are still inconclusive. Systemic inflammation-induced neuroinflammation is kno

Externí odkaz: https://doaj.org/article/5f4ba7c689f44ac8b443878989b34866

Fructose milieu undermines the therapeutic effect of Tribulus terrestris extract on neuroblastoma cell line via maintaining mitochondrial function

Autor: Jing‐Ru Weng, Chih‐Wei Wu, Yu‐Chia Chen, Mu‐Hui Fu, You‐Lin Tain, Chun‐Ying Hung, I‐Chun Chen, Chu‐Wan Lee, Kay L. H. Wu

Publikováno v: Environmental toxicologyREFERENCES. 37(11)

Fructose overconsumption promotes tumor progression. Neuroblastoma is a common extracranial tumor with about 50% 5-year survival rate in high-risk children. The anti-tumor effect of Tribulus terrestris might bring new hope to neuroblastoma therapy. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e99c470c650187d52271de9c535cb1bc
https://pubmed.ncbi.nlm.nih.gov/36214339

Pioglitazone reversed the fructose-programmed astrocytic glycolysis and oxidative phosphorylation of female rat offspring

Autor: You-Lin Tain, X. Kay L.H. Wu, Wei Chia Lee, Yu Chih Kung, Ying Hao Ho, Julie Y.H. Chan, Chun Ying Hung, Steve Leu, Hajime Hirase, Chih-Wei Wu, Mu Hui Fu, Wen Chung Liu, Chih-Kuang Liang, X. Lee Wei Chen

Publikováno v: American Journal of Physiology-Endocrinology and Metabolism. 316:E622-E634

Excessive maternal high-fructose diet (HFD) during pregnancy and lactation has been reported to cause metabolic disorders in the offspring. Whether the infant’s brain metabolism is disturbed by maternal HFD is largely unknown. Brain energy metaboli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750f7871d0da3d0bfad09ea57648fe5e
https://doi.org/10.1152/ajpendo.00408.2018

Environmental Stimulation Counteracts the Suppressive Effects of Maternal High-Fructose Diet on Cell Proliferation and Neuronal Differentiation in the Dentate Gyrus of Adult Female Offspring via Histone Deacetylase 4

Autor: Mu-Hui Fu, Julie Y.H. Chan, Chih-Kuang Liang, You-Lin Tain, Chun-Ying Hung, Pi-Lien Hung, Hong-Ren Yu, Lee Wei Chen, Wen-Chung Liu, Kay L.H. Wu, Chih-Wei Wu, I-Chun Chen

Publikováno v: International Journal of Environmental Research and Public Health
Volume 17
Issue 11
International Journal of Environmental Research and Public Health, Vol 17, Iss 3919, p 3919 (2020)

Maternal high-fructose diets (HFD) impair the learning and memory capacity of adult female offspring via histone deacetylase 4 (HDAC4). Hippocampal adult neurogenesis is important for supporting the function of existing neural circuits. In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58595dccefaef09b8c39d7731c28b8d2