Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Chun‐Ping Cui"'
Autor:
Yuan Liu, Dianke Li, Xin Zhang, Simin Xia, Yingjie Qu, Xinping Ling, Yang Li, Xiangren Kong, Lingqiang Zhang, Chun-Ping Cui, Dong Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Protein ubiquitination regulates a wide range of cellular processes. The degree of protein ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated ubiquitination and deubiquitinase (DUB)-mediated deubiquit
Externí odkaz:
https://doaj.org/article/c47a76b0a49f450ea1fcc1bfc36c2a15
Autor:
Yesheng Fu, Lei Li, Xin Zhang, Zhikang Deng, Ying Wu, Wenzhe Chen, Yuchen Liu, Shan He, Jian Wang, Yuping Xie, Zhiwei Tu, Yadi Lyu, Yange Wei, Shujie Wang, Chun-Ping Cui, Cui Hua Liu, Lingqiang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Linear ubiquitination catalyzed by HOIL-1-interacting protein (HOIP), the key component of the linear ubiquitination assembly complex, plays fundamental roles in tissue homeostasis by executing domain-specific regulatory functions. However,
Externí odkaz:
https://doaj.org/article/09b2ff03ca9a446d8ca7c4399fcaf6cf
Autor:
Yonghui Zhang, Tongde Du, Na Liu, Juan Wang, Lingqiang Zhang, Chun-Ping Cui, Chaonan Li, Xin Zhang, Bo Wu, Jinhao Zhang, Wenli Jiang, Yubing Zhang, Yuting Zhang, Hongchang Li, Peiyu Li
Publikováno v:
Cell Death and Disease, Vol 14, Iss 6, Pp 1-14 (2023)
Abstract The ubiquitin-proteasome system (UPS) controls protein turnover, and its dysfunction contributes to human diseases including cancer. Deubiquitinating enzymes (DUBs) remove ubiquitin from proteins to maintain their stability. Inhibition of DU
Externí odkaz:
https://doaj.org/article/8c17b34966eb49178fa9953bb539178d
Autor:
Qiong Zhu, Yesheng Fu, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu, Lingqiang Zhang
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-13 (2023)
Abstract Bone homeostasis is maintained by the balance between osteoblastic bone formation and osteoclastic bone resorption. Dysregulation of this process leads to multiple diseases, including osteoporosis. However, the underlying molecular mechanism
Externí odkaz:
https://doaj.org/article/490a71723b3b4584a6d8895932462b14
Autor:
Lei Li, Rui Zhu, Honghong Zhou, Chun‐Ping Cui, Xiao Yu, Yuhao Liu, Yin Yin, Yang Li, Riyue Feng, Jonathan P. Katz, Yahui Zhao, Yun Zhang, Lingqiang Zhang, Zhihua Liu
Publikováno v:
Advanced Science, Vol 10, Iss 16, Pp n/a-n/a (2023)
Abstract β‐TrCP is an E3 ubiquitin ligase that plays important roles in multiple human cancers including esophageal squamous cell carcinoma (ESCC). Analysis of ESCC patient samples reveal that only protein level but not transcript level of β‐Tr
Externí odkaz:
https://doaj.org/article/b242253180974424bb1c215e632f7a0b
Autor:
Kai Guo, Yinghua Wei, Ze Wang, Xiaoli Zhang, Xin Zhang, Xinxin Liu, Wenyong Wu, Zhengsheng Wu, Lingqiang Zhang, Chun-Ping Cui
Publikováno v:
Cell Death and Disease, Vol 13, Iss 2, Pp 1-11 (2022)
Abstract Von Hippel-Lindau (VHL) is an important tumor suppressor, and its inactivation is a hallmark of inherited VHL disease and most sporadic clear cell renal cell carcinoma (ccRCC). VHL protein (pVHL) with missense point mutations are unstable an
Externí odkaz:
https://doaj.org/article/2c22b5cb21444a5fbeed2b67251f02af
Autor:
Hongchang Li, Chaonan Li, Wenjing Zhai, Xin Zhang, Lei Li, Bo Wu, Biyue Yu, Pengfei Zhang, Jie Li, Chun-Ping Cui, Lingqiang Zhang
Publikováno v:
Cell Reports, Vol 41, Iss 1, Pp 111435- (2022)
Summary: Autophagy is essential for the maintenance of energy homeostasis and for survival during the neonatal starvation period. At birth, the trans-placental nutrient supply is suddenly interrupted, and neonates adapt to this adverse circumstance b
Externí odkaz:
https://doaj.org/article/3088983583194a69bec6e3e4dbf388c9
Autor:
Xiaoli Zhang, Ze Wang, Qing Xu, Yuhan Chen, Wen Liu, Tong Zhong, Hongchang Li, Chengshi Quan, Lingqiang Zhang, Chun-Ping Cui
Publikováno v:
iScience, Vol 24, Iss 10, Pp 103097- (2021)
Summary: The serine/arginine-rich (SR) family of splicing factors plays important roles in mRNA splicing activation, repression, export, stabilization, and translation. SR-splicing factor 5 (SRSF5) is a glucose-inducible protein that promotes tumor c
Externí odkaz:
https://doaj.org/article/4e7296b750de47f38845358d009653ee
Autor:
Lijie Zhou, Yingwei Ge, Yesheng Fu, Bo Wu, Yong Zhang, Lei Li, Chun-Ping Cui, Siying Wang, Lingqiang Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Linear ubiquitination is a reversible posttranslational modification, which plays key roles in multiple biological processes. Linear ubiquitin chain assembly complex (LUBAC) catalyzes linear ubiquitination, while the deubiquitinase OTULIN (OTU deubiq
Externí odkaz:
https://doaj.org/article/fa2c4e6ad3d640b5a7a8e529027aa426
Autor:
Tongde Du, Hongchang Li, Yongsheng Fan, Lin Yuan, Xiaodan Guo, Qiong Zhu, Yuying Yao, Xin Li, Chunlei Liu, Xinhe Yu, Zhaofei Liu, Chun-Ping Cui, Chuanchun Han, Lingqiang Zhang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
The deubiquitylase OTUD3 can function as a tumour-suppressor by stabilizing PTEN. Here, the authors show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein GRP78.
Externí odkaz:
https://doaj.org/article/ab1f8b5e1844405cb2061fdd5a0b4699