Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking

Autor: Moragot Chatatikun, Nawanwat C. Pattaranggoon, Imran Sama-ae, Onggan Ranteh, Manlika Poolpirom, Oranan Pantanakong, Pitchaporn Chumworadet, Fumitaka Kawakami, Motoki Imai, Aman Tedasen

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)

Abstract G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that have gained considerable attention as drug targets, particularly in cancer treatment. In this study, we explored the capacity of bioactive compounds derived from Gnetum

Externí odkaz: https://doaj.org/article/64a51f6c99b24ae98952e68ffbf0a473

Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking.

Autor: Chatatikun M; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand.; Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80161, Thailand., Pattaranggoon NC; Faculty of Medical Technology, Rangsit University, Muang Pathumthani, Pathumthani, 12000, Thailand.; Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, 10330, Thailand., Sama-Ae I; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand.; Center of Excellence Research for Melioidosis and Microorganisms (CERMM), Walailak University, Nakhon Si Thammarat, 80161, Thailand., Ranteh O; Department of Community Public Health, School of Public Health, Walailak University, Nakhon Si Thammarat, 80161, Thailand.; Excellent Center for Dengue and Community Public Health (EC for DACH), Walailak University, Nakhon Si Thammarat, 80161, Thailand., Poolpirom M; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand., Pantanakong O; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand., Chumworadet P; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand., Kawakami F; Research Facility of Regenerative Medicine and Cell Design, School of Allied Health Sciences, Kitasato University, Sagamihara, 252-0373, Japan.; Department of Regulatory Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara, 252-0373, Japan., Imai M; Research Facility of Regenerative Medicine and Cell Design, School of Allied Health Sciences, Kitasato University, Sagamihara, 252-0373, Japan.; Department of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Sagamihara, 252-0373, Japan., Tedasen A; School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, 80161, Thailand. aman.te@wu.ac.th.; Research Excellence Center for Innovation and Health Products, Walailak University, Nakhon Si Thammarat, 80161, Thailand. aman.te@wu.ac.th.

Publikováno v: Scientific reports [Sci Rep] 2024 Oct 28; Vol. 14 (1), pp. 25738. Date of Electronic Publication: 2024 Oct 28.