Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Chull Hong"'
Autor:
Nirmala Hariharan, Yoshiyuki Ikeda, Chull Hong, Ralph R Alcendor, Soichiro Usui, Shumin Gao, Yasuhiro Maejima, Junichi Sadoshima
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e51632 (2013)
Autophagy is a bulk degradation mechanism for cytosolic proteins and organelles. The heart undergoes hypertrophy in response to mechanical load but hypertrophy can regress upon unloading. We hypothesize that autophagy plays an important role in media
Externí odkaz:
https://doaj.org/article/cc467d8acf604565a1b84302e1533dfa
Autor:
Constance L. Coogle, Sung-chull Hong
Publikováno v:
Journal of Applied Gerontology. 35:759-787
Spousal caregiving allows stressed couples to continue living in the community rather than seeking institutional solutions. Dr. Toni Calasanti has postulated that there are gender differences in the care work styles and coping strategies used by spou
Autor:
Paulo Lizano, Kiran Madura, Nadia Hedhli, Stephen F. Vatner, Shumin Gao, Yimin Tian, Huasheng Liu, Sunil Dhar, Christophe Depre, Luke F. Fritzky, Chull Hong
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H1385-H1393
We tested the possibility that proteasome inhibition may reverse preexisting cardiac hypertrophy and improve remodeling upon pressure overload. Mice were submitted to aortic banding and followed up for 3 wk. The proteasome inhibitor epoxomicin (0.5 m
Autor:
Chull Hong, Dorothy E. Vatner, Jayashree Pain, Rhina Shah, Komal Jain, Stephen F. Vatner, Christophe Depre, Hongyu Qiu, Bin Tian, Huacheng Dai
Publikováno v:
Journal of Biological Chemistry. 283:22157-22165
Myocardial infarction (MI) is often followed by heart failure (HF), but the mechanisms precipitating the transition to HF remain largely unknown. A genomic profile was performed in a monkey model of MI, from the myocardium adjacent to chronic (2-mont
Autor:
Dorothy E. Vatner, You-Tang Shen, Jeffrey Robbins, Junichi Sadoshima, Chull Hong, Yoshihiro Ishikawa, Takao Nishizawa, Stephen F. Vatner, Franco Rossi
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 292:H971-H975
Both enhanced sympathetic drive and altered autonomic control are involved in the pathogenesis of heart failure. The goal of the present study was to determine the extent to which chronically enhanced sympathetic drive, in the absence of heart failur
Pressure overload induces greater hypertrophy and mortality in female mice with p38α MAPK inhibition
Autor:
Guiping Yang, Wei Chen, Chull Hong, Junichi Sadoshima, Yibin Wang, Jing Liu, Dorothy E. Vatner, Peiyong Zhai, Stephen F. Vatner, Lin Yan
Publikováno v:
Journal of Molecular and Cellular Cardiology. 41:680-688
We examined pressure overload left ventricular (LV) hypertrophy (H) induced by aortic banding in transgenic mice with cardiac-specific expression of a dominant negative (DN) p38alpha (TG) and wild type controls (WT). In response to chronic pressure o
Autor:
Junichi Sadoshima, Jeffrey Robbins, Yoshihiro Ishikawa, Stephen F. Vatner, Stefan E. Hardt, Dorothy E. Vatner, You-Tang Shen, Takao Nishizawa, Chull Hong
Publikováno v:
Journal of Molecular and Cellular Cardiology. 41:44-50
We overexpressed cardiac Gsalpha in rabbits using the beta-myosin heavy chain promoter. Gsalpha protein levels in the heart were increased 3-fold by Western blotting in both juvenile (3-4 months), adult (8-10 months), and older (11-16 months) rabbits
Autor:
Amy M. Shah, Xiangzhen Sui, Vinciane Gaussin, Michel Pelat, Nadia Hedhli, Hongyu Qiu, Chull Hong, Audrey Ginion, Thomas Wagner, Stephen F. Vatner, Luc Bertrand, Li Wang, Christophe Depre
Publikováno v:
Circulation Research. 98:280-288
Ischemic preconditioning confers powerful protection against myocardial infarction through pre-emptive activation of survival signaling pathways, but it remains difficult to apply to patients with ischemic heart disease, and its effects are transient
Autor:
In-Chull Hong, David
Publikováno v:
Yonsei Medical Journal; Feb2019, Vol. 60 Issue 2, p119-125, 7p
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
Autor:
Mitsutaka Yamamoto, Guiping Yang, Chull Hong, Jing Liu, Eric Holle, Xianzhong Yu, Thomas Wagner, Stephen F. Vatner, Junichi Sadoshima
Publikováno v:
Journal of Clinical Investigation. 112:1395-1406
Thioredoxin 1 (Trx1) has redox-sensitive cysteine residues and acts as an antioxidant in cells. However, the extent of Trx1 contribution to overall antioxidant mechanisms is unknown in any organs. We generated transgenic mice with cardiac-specific ov