Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chulbul M. I. Ahmed"'
Autor:
Howard M. Johnson, Chulbul M. I. Ahmed, Cristhian J Ildefonso, Michael T. Massengill, Alfred S. Lewin
We describe an immunosuppressive peptide corresponding to the kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1) that binds to the phospho-tyrosine containing regions of the tyrosine kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9944ed39d481fa1cbc6ee294e20ed4d
https://doi.org/10.1101/315549
https://doi.org/10.1101/315549
Autor:
Michael T. Massengill, Howard M. Johnson, Cristhian J Ildefonso, Alfred S. Lewin, Chulbul M. I. Ahmed, Emily E. Brown
Publikováno v:
Experimental eye research. 177
We describe an immunosuppressive peptide corresponding to the kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1) that binds to the phospho-tyrosine containing regions of the tyrosine kin
Publikováno v:
Biochemical and Biophysical Research Communications. 410:648-653
We previously showed that gamma interferon (IFNγ) and its receptor subunit, IFNGR1, interacted with the promoter region of IFNγ-activated genes along with transcription factor STAT1α. Recent studies have suggested that activated Janus kinases pJAK
Autor:
Howard M. Johnson, James P. Martin, S. Mohammad Haider, Rea Dabelic, Chulbul M. I. Ahmed, Lindsey D. Jager
Publikováno v:
The Journal of Immunology. 185:1103-1113
Suppressors of cytokine signaling (SOCSs) are negative regulators of both innate and adaptive immunity via inhibition of signaling by cytokines such as type I and type II IFNs. We have developed a small peptide antagonist of SOCS-1 that corresponds t
Publikováno v:
The Journal of Immunology. 178:4576-4583
We have developed small peptide mimetics of IFN-γ that can bypass the poxvirus virulence factor B8R protein, which binds to intact IFN-γ and prevents its interaction with receptor extracellular domain. Thus, these peptides inhibit vaccinia virus re
Autor:
Haoyu Mao, Hong Li, Manas R. Biswal, Chulbul M. I. Ahmed, Cristhian J Ildefonso, Pingyang Han, Hiral Jivanji, Alfred S. Lewin
Publikováno v:
Experimental eye research. 140
Chronic oxidative stress contributes to age related diseases including age related macular degeneration (AMD). Earlier work showed that the 5-hydroxy-tryptamine 1a (5HT1a) receptor agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) protects
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 6 (2015)
Frontiers in Immunology, Vol 6 (2015)
Suppressors of cytokine signaling (SOCS) are inducible intracellular proteins that play essential regulatory roles in both immune and non-immune function. Of the eight known members, SOCS1 and SOCS3 in conjunction with regulatory T cells play key rol
Autor:
T.L. Nagabhushan, Duane E. Johnson, Barry J. Sugarman, Wills Ken N, Robert Bookstein, Chulbul M. I. Ahmed, Diganta Saha
Publikováno v:
Human Gene Therapy. 10:77-84
A replication-deficient adenovirus encoding human interferon alpha2b, driven by the human cytomegalovirus (CMV) promoter, was constructed and characterized. This construct was used to infect human cells derived from different types of cancer. The pro
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 4 (2013)
Frontiers in Immunology, Vol 4 (2013)
Regulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFNγ) mediated, lethal auto-immunity occurs (in both mice and humans) in their absence. In addition, Tregs have been implicated in pr
Autor:
Chulbul M. I. Ahmed, Howard M. Johnson, Samuel David, Rea Dabelic, Joseph Larkin, Mohammad S. Haider, Kenneth Lau, Lilian W. Waiboci, Lindsey D. Jager
Suppressors of cytokine signaling (SOCS) negatively regulate the immune response, primarily by interfering with the JAK/STAT pathway. We have developed a small peptide corresponding to the kinase inhibitory region (KIR) sequence of SOCS-1, SOCS1-KIR,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f6bcfb32a43a40ac6f9a67c20eaab7
https://europepmc.org/articles/PMC3053067/
https://europepmc.org/articles/PMC3053067/