Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Chulbul M. Ahmed"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Several blinding diseases affecting the retina and optic nerve are exacerbated by or caused by dysregulated inflammation and oxidative stress. These diseases include uveitis, age related macular degeneration, diabetic retinopathy and glaucoma. Conseq
Externí odkaz:
https://doaj.org/article/faf377a14b604fb2a3387fd7df03b52d
Autor:
Howard M. Johnson, Chulbul M. Ahmed
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The field of antiviral therapeutics is fixated on COVID19 and rightly so as the fatalities at the height of the pandemic in the United States were almost 1,000,000 in a twelve month period spanning parts of 2020/2021. A coronavirus called SARS–CoV2
Externí odkaz:
https://doaj.org/article/9436ac93708148c6bf66ab3256a5a877
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Suppressors of Cytokine Signaling (SOCS) are intracellular proteins that negatively regulate the induction of cytokines. Amongst these, SOCS1 and SOCS3 are particularly involved in inhibition of various interferons. Several viruses have hijacked this
Externí odkaz:
https://doaj.org/article/f14a39f81f2e4ab39fe1516039cbb7dc
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The suppressor of cytokine signaling (SOCS) family of intracellular checkpoint inhibitors has received little recognition compared to other checkpoint inhibitors. Two members of this family, SOCS1 and SOCS3, are indispensable, since SOCS1 knockout in
Externí odkaz:
https://doaj.org/article/89710bf294e34346aeb177d1c963eedd
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
A small group of only seven transcription factors known as STATs (signal transducer and activator of transcription) are considered to be canonical determinants of specific gene activation for a plethora of ligand/receptor systems. The activation of S
Externí odkaz:
https://doaj.org/article/f946a26c3be04cd59994ea5e6748b230
Autor:
Howard M. Johnson, Chulbul M. Ahmed
Publikováno v:
Mediators of Inflammation, Vol 2016 (2016)
The canonical model of cytokine signaling via the JAK/STAT pathway dominates our view of signal transduction but provides no insight into the significance of the simultaneous presence of activated JAKs and STATs in the nucleus of cells treated with c
Externí odkaz:
https://doaj.org/article/159587e6294449e28a3cd007d4435de0
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
We have developed an antagonist to suppressor of cytokine signaling 1 (SOCS1), pJAK2(1001-1013), that corresponds to the activation loop of the Janus kinase JAK2, which is the binding site for the kinase inhibitory region (KIR) of SOCS1. Internalized
Externí odkaz:
https://doaj.org/article/2f3bad0dc4034a91ba20b6ee13126a12
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Suppressors of cytokine signaling (SOCS) are inducible intracellular proteins that play essential regulatory roles in both immune and non-immune function. Of the eight known members, SOCS1 and SOCS3 in conjunction with regulatory T cells play key rol
Externí odkaz:
https://doaj.org/article/c91bf6038463483f96adc2b97563e1fb
Regulation of interferon gamma signaling by suppressors of cytokine signaling and regulatory T cells
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Regulatory T cells (Tregs) play an indispensable role in the prevention of autoimmune disease, as interferon gamma (IFN) mediated, lethal autoimmunity occurs (in both mice and humans) in their absence. In addition, regulatory T cells have been imp
Externí odkaz:
https://doaj.org/article/3fa82b782ef64980bedb72f1b63d385b
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
The classical model of cytokine signaling dominates our view of specific gene activation by cytokines such as the interferons (IFNs). The importance of the model extends beyond cytokines and applies to hormones such as growth hormone (GH) and insulin
Externí odkaz:
https://doaj.org/article/43dbf1a849f747ca946fdb092c9d60ff