Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Chul Joo Kang"'
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascula
Externí odkaz:
https://doaj.org/article/00a5662500fa4216a282bb3c8ddfa931
Autor:
Liron Ganel, Lei Chen, Ryan Christ, Jagadish Vangipurapu, Erica Young, Indraniel Das, Krishna Kanchi, David Larson, Allison Regier, Haley Abel, Chul Joo Kang, Alexandra Scott, Aki Havulinna, Charleston W. K. Chiang, Susan Service, Nelson Freimer, Aarno Palotie, Samuli Ripatti, Johanna Kuusisto, Michael Boehnke, Markku Laakso, Adam Locke, Nathan O. Stitziel, Ira M. Hall
Publikováno v:
Human Genomics, Vol 15, Iss 1, Pp 1-17 (2021)
Abstract Background Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a c
Externí odkaz:
https://doaj.org/article/afd0fb03735e45e7af8157b2896c588c
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/7c4ce03f276947c5a06906eedf5397a8
Autor:
D'Erasmo, Laura, Di Martino, Michele, Neufeld, Thomas, Fraum, Tyler J., Chul Joo Kang, Burks, Kendall H., Di Costanzo, Alessia, Minicocci, Ilenia, Bini, Simone, Maranghi, Marianna, Pigna, Giovanni, Labbadia, Giancarlo, Zheng, Jie, Fierro, Davide, Montali, Anna, Ceci, Fabrizio, Catalano, Carlo, Davidson, Nicholas O., Lucisano, Giuseppe, Nicolucci, Antonio
Publikováno v:
Circulation; 11/7/2023, Vol. 148 Issue 19, p1479-1489, 11p
Autor:
Jared S Elenbaas, Upasana Pudupakkam, Ved Patel, Katrina Ashworth, Chul Joo Kang, In-Hyuk Jung, Katherine Santana, Arturo Alisio, Jorge Di Paola, Nathan Stitziel
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 42
Background: Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1) is an extracellular matrix protein that circulates in plasma and is causally related to cardiovascular disease, hypertension, and type 2 diabetes. A recent
Autor:
Charleston W. K. Chiang, Ira M. Hall, Nelson B. Freimer, Aarno Palotie, Michael Boehnke, David E. Larson, Alexandra J. Scott, Krishna L. Kanchi, Allison A. Regier, Lei Chen, Erica Young, Johanna Kuusisto, Samuli Ripatti, Chul Joo Kang, Nathan O. Stitziel, Ryan Christ, Haley J. Abel, Indraniel Das, Adam E. Locke, Markku Laakso, Jagadish Vangipurapu, Aki S. Havulinna, Liron Ganel
Publikováno v:
Human Genomics
Human Genomics, Vol 15, Iss 1, Pp 1-17 (2021)
Human genomics, vol 15, iss 1
Human Genomics, Vol 15, Iss 1, Pp 1-17 (2021)
Human genomics, vol 15, iss 1
Background Mitochondrial genome copy number (MT-CN) varies among humans and across tissues and is highly heritable, but its causes and consequences are not well understood. When measured by bulk DNA sequencing in blood, MT-CN may reflect a combinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3571fd60bd62350794f27d98e14101eb
http://hdl.handle.net/10138/333048
http://hdl.handle.net/10138/333048
Autor:
Nathan O. Stitziel, Alexandra J. Scott, Allison A. Regier, Chul Joo Kang, Aki S. Havulinna, Lei Chen, Colby Chiang, Charleston W. K. Chiang, Liron Ganel, Aarno Palotie, Shuangjia Lu, Nelson B. Freimer, Erica P. Young, Ryan Christ, Johanna Kuusisto, Ira M. Hall, Xinxin Wang, Adam E. Locke, Indraniel Das, David E. Larson, Krishna L. Kanchi, Samuli Ripatti, Haley J. Abel, Michael Boehnke, Markku Laakso
Publikováno v:
American journal of human genetics, vol 108, iss 4
Am J Hum Genet
Am J Hum Genet
The contribution of genome structural variation (SV) to quantitative traits associated with cardiometabolic diseases remains largely unknown. Here, we present the results of a study examining genetic association between SVs and cardiometabolic traits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c832a8ee03956867402e4f3cdc4da0f6
https://escholarship.org/uc/item/9wd603z3
https://escholarship.org/uc/item/9wd603z3
Autor:
Erica P. Young, Robert P. Mecham, Puja Kachroo, In Hyuk Jung, Katherine Santana, Arturo Alisio, Jared S. Elenbaas, Kory J. Lavine, Babak Razani, Chul Joo Kang, Nathan O. Stitziel
Publikováno v:
Sci Transl Med
A low-frequency variant of sushi, von Willebrand factor type A, EGF and pentraxin domain containing protein 1 (SVEP1), an extracellular matrix protein, is associated with risk of coronary disease in humans independent of plasma lipids. Despite a robu
Autor:
David E. Larson, Allison A. Regier, Aarno Palotie, Shuangjia Lu, Nelson B. Freimer, Colby Chiang, Aki S. Havulinna, Markku Laakso, Xinxin Wang, Lei Chen, Erica P. Young, Adam E. Locke, Ryan Christ, Samuli Ripatti, Charleston W. K. Chiang, Nathan O. Stitziel, Liron Ganel, Johanna Kuusisto, Indraniel Das, Alexandra J. Scott, Ira M. Hall, Michael Boehnke, Chul Joo Kang, Krishna L. Kanchi, Haley J. Abel
The contribution of genome structural variation (SV) to quantitative traits associated with cardiometabolic diseases remains largely unknown. Here, we present the results of a study examining genetic association between SVs and cardiometabolic traits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9654cb6887480e67513f056a2fa53428
https://doi.org/10.1101/2020.12.13.422502
https://doi.org/10.1101/2020.12.13.422502