Genome-Wide Methylation Profiling in 229 Patients With Crohn’s Disease Requiring Intestinal Resection: Epigenetic Analysis of the Trial of Prevention of Post-operative Crohn’s Disease (TOPPIC)Summary

Autor: Nicholas T. Ventham, Nicholas A. Kennedy, Rahul Kalla, Alex T. Adams, Alexandra Noble, Holly Ennis, Craig Mowat, Malcolm G. Dunlop, Jack Satsangi, Ian Arnott, Aiden Cahill, Malcolm Smith, Tariq Ahmad, Sreedhar Subramanian, Simon Travis, John Morris, John Hamlin, Anjan Dhar, Chuka Nwokolo, Cathryn Edwards, Tom Creed, Stuart Bloom, Mohamed Yousif, Linzi Thomas, Simon Campbell, Stephen J. Lewis, Shaji Sebastian, Sandip Sen, Simon Lal, Chris Hawkey, Charles Murray, Fraser Cummings, Jason Goh, James O. Lindsay, Naila Arebi, Lindsay Potts, Aileen J. McKinley, John M. Thomson, John A. Todd, Mhairi Collie, Ashley Mowat, Daniel R. Gaya, Jack Winter, Graham D. Naismith, Catriona Keerie, Steff Lewis, Robin J. Prescott, Gordan Lauc, Harry Campbell, Dermot P.B. McGovern, Vito Annese, Vlatka Zoldoš, Iain K. Permberton, Manfred Wuhrer, Daniel Kolarich, Daryl L. Fernandes, Evropi Theorodorou, Victoria Merrick Daniel I. Spencer, Richard A. Gardner, Ray Doran, Archana Shubhakar, Ray Boyapati, Igor Rudan, Paolo Lionetti, Irena Trbojević Akmačić, Jasminka Krištić, Frano Vuč ković, Jerko Štambuk, Mislav Novokmet, Maja Pučić-Baković, Olga Gornik, Angelo Andriulli, Laura Cantoro, Giancarlo Sturniolo, Gionata Fiorino, Natalia Manetti, Anna Latiano, Anna Kohn, Renata D’Inca`, Silvio Danese, Ian D. Arnott, Colin L. Noble, Charlie W. Lees, Alan G. Shand, Gwo-Tzer Ho, Lee Murphy, Jude Gibson, Louise Evenden, Nicola Wrobel, Tamara Gilchrist, Angie Fawkes, Guinevere S.M. Kammeijer, Florent Clerc, Noortje de Haan, Aleksandar Vojta, Ivana Samaržija, Dora Markulin, Marija Klasić, Paula Dobrinić, Yurii Aulchenko, Tim van den Heuve, Daisy Jonkers, Marieke Pierik

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 431-450 (2023)

Background & Aims: DNA methylation alterations may provide important insights into gene-environment interaction in cancer, aging, and complex diseases, such as inflammatory bowel disease (IBD). We aim first to determine whether the circulating DNA me

Externí odkaz: https://doaj.org/article/f32b67ecfa854c6487a3c5196a5070e3

Minimal Gluten Exposure Alters Urinary Volatile Organic Compounds in Stable Coeliac Disease

Autor: Michael McFarlane, Ramesh P. Arasaradnam, Beryl Reed, Emma Daulton, Alfian Wicaksono, Heena Tyagi, James A. Covington, Chuka Nwokolo

Publikováno v: Sensors, Vol 22, Iss 3, p 1290 (2022)

Coeliac disease (CD) patients are distinguishable from healthy individuals via urinary volatile organic compounds (VOCs) analysis. We exposed 20 stable CD patients on gluten-free diet (GFDs) to a 14-day, 3 g/day gluten challenge (GCh), and assessed u

Externí odkaz: https://doaj.org/article/391d3797222c488d857b2055d57ee85e

Variation in Gas and Volatile Compound Emissions from Human Urine as It Ages, Measured by an Electronic Nose

Autor: Siavash Esfahani, Nidhi M. Sagar, Ioannis Kyrou, Ella Mozdiak, Nicola O’Connell, Chuka Nwokolo, Karna D. Bardhan, Ramesh P. Arasaradnam, James A. Covington

Publikováno v: Biosensors, Vol 6, Iss 1, p 4 (2016)

The medical profession is becoming ever more interested in the use of gas-phase biomarkers for disease identification and monitoring. This is due in part to its rapid analysis time and low test cost, which makes it attractive for many different clini

Externí odkaz: https://doaj.org/article/3fac0ad5a47746f4919724d45e30c931

Magnetic resonance imaging in Crohn's disease

Autor: Paul D Murphy, Chuka Nwokolo, Rakesh Sinha

Publikováno v: BMJ (Clinical research ed.). 336(7638)

This article explores the use of magnetic resonance imaging as an emerging modality in the investigation of Crohn’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4089cd9f4542dd6e3838f235feda3e34
https://pubmed.ncbi.nlm.nih.gov/18245000