Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Chujiao Lin"'
Autor:
Chujiao Lin, Qiyuan Yang, Dongsheng Guo, Jun Xie, Yeon-Suk Yang, Sachin Chaugule, Ngoc DeSouza, Won-Taek Oh, Rui Li, Zhihao Chen, Aijaz A. John, Qiang Qiu, Lihua Julie Zhu, Matthew B. Greenblatt, Sankar Ghosh, Shaoguang Li, Guangping Gao, Cole Haynes, Charles P. Emerson, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Skeletal progenitors provide a reservoir for bone-forming osteoblasts. However, the major energy source for their osteogenesis remains unresolved. Here, the authors demonstrate that ESCIT-mediated regulation of mitochondrial metabolism is required fo
Externí odkaz:
https://doaj.org/article/7ba9a8c0d31344639b3d19b6b3e7140e
Autor:
Yeon-Suk Yang, Jung-Min Kim, Jun Xie, Sachin Chaugule, Chujiao Lin, Hong Ma, Edward Hsiao, Jaehyoung Hong, Hyonho Chun, Eileen M. Shore, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Fibrodysplasia ossificans progressiva is an ultra-rare genetic disorder with progressive heterotopic ossification. Yang et al develop different gene therapy approaches and show their efficacy in mouse models and in human induced pluripotent stem cell
Externí odkaz:
https://doaj.org/article/261d337857a4449b8131eb048cff41f6
Autor:
Aijaz Ahmad John, Jun Xie, Yeon-Suk Yang, Jung-Min Kim, Chujiao Lin, Hong Ma, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 296-311 (2022)
Osteoporosis occurs due to a dysregulation in bone remodeling, a process requiring both bone-forming osteoblasts and bone-resorbing osteoclasts. Current leading osteoporosis therapies suppress osteoclast-mediated bone resorption but show limited ther
Externí odkaz:
https://doaj.org/article/6a863fcf948c40ecacdf2bebc2956fdb
Autor:
Yeon-Suk Yang, Chujiao Lin, Hong Ma, Jun Xie, Frederick S. Kaplan, Guangping Gao, Jae-Hyuck Shim
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1364 (2023)
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare genetic disorder characterized by progressive disabling heterotopic ossification (HO) at extra-skeletal sites. Here, we developed adeno-associated virus (AAV)-based gene therapy that suppre
Externí odkaz:
https://doaj.org/article/40696c78b90643a9a83c19fbbdd827bd
Autor:
Shuaitong Yu, Jinqiang Guo, Zheyi Sun, Chujiao Lin, Huangheng Tao, Qian Zhang, Yu Cui, Huanyan Zuo, Yuxiu Lin, Shuo Chen, Huan Liu, Zhi Chen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Abstract Transcription factors (TFs) regulate the expression of target genes, inducing changes in cell morphology or activities needed for cell fate determination and differentiation. The BMP signaling pathway is widely regarded as one of the most im
Externí odkaz:
https://doaj.org/article/73050ec8bc664b8d89a7bca4ecf942c0
Autor:
Qian Zhang, Zhen Huang, Huanyan Zuo, Yuxiu Lin, Yao Xiao, Yanan Yan, Yu Cui, Chujiao Lin, Fei Pei, Zhi Chen, Huan Liu
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Embryonic development and stem cell differentiation are orchestrated by changes in sequential binding of regulatory transcriptional factors to their motifs. These processes are invariably accompanied by the alternations in chromatin accessibility, co
Externí odkaz:
https://doaj.org/article/9fe09b4540d44cbfa33cca7a23a465d3
Publikováno v:
Cells, Vol 9, Iss 9, p 2073 (2020)
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct c
Externí odkaz:
https://doaj.org/article/fdd9e0ba06454092a214d2597d81dba9
Publikováno v:
Experimental & Molecular Medicine. 55:69-80
Haploinsufficiency of Runt-related transcription factor-2 (RUNX2) is responsible for cleidocranial dysplasia (CCD), a rare hereditary disease with a range of defects, including delayed closure of the cranial sutures and short stature. Symptom-based t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f20de919a6d9e930c3dee572bcd72f
https://doi.org/10.1038/s12276-022-00914-w
https://doi.org/10.1038/s12276-022-00914-w
Autor:
Qian Zhang, Yu Cui, Chujiao Lin, Huangheng Tao, Huan Liu, Shuo Chen, Shuaitong Yu, Zheyi Sun, Yuxiu Lin, Jinqiang Guo, Zhi Chen, Huanyan Zuo
Publikováno v:
Cell Death and Disease, Vol 12, Iss 2, Pp 1-17 (2021)
Cell Death & Disease
Cell Death & Disease
Transcription factors (TFs) regulate the expression of target genes, inducing changes in cell morphology or activities needed for cell fate determination and differentiation. The BMP signaling pathway is widely regarded as one of the most important p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b230fb193808496640a66180fa11f84
https://doaj.org/article/73050ec8bc664b8d89a7bca4ecf942c0
https://doaj.org/article/73050ec8bc664b8d89a7bca4ecf942c0
Publikováno v:
Stem cells (Dayton, Ohio)REFERENCES. 39(2)
Mouse dental papilla cells (mDPCs) derive from cranial neural crest cells and maintain mesenchymal stem cell characteristics. The differentiation of neural crest cells into odontoblasts is orchestrated by transcription factors regulating the expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aba716f2577ad19b31acd61070dcc8b1
https://pubmed.ncbi.nlm.nih.gov/33159702
https://pubmed.ncbi.nlm.nih.gov/33159702