Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Chuin Lean Tham"'
Autor:
Gabriele Bassi, Nicholas Favalli, Miriam Vuk, Marco Catalano, Adriano Martinelli, Anika Trenner, Antonio Porro, Su Yang, Chuin Lean Tham, Mustafa Moroglu, Wyatt W. Yue, Stuart J. Conway, Peter K. Vogt, Alessandro A. Sartori, Jörg Scheuermann, Dario Neri
Publikováno v:
Advanced Science, Vol 7, Iss 22, Pp n/a-n/a (2020)
Abstract A versatile and Lipinski‐compliant DNA‐encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, and characterized. The GB‐D
Externí odkaz:
https://doaj.org/article/6523af672d2b411ba7e7080f84e45492
Autor:
Mahmoud E. S. Soliman, Chandrasekaran Balakumar, Nisar Sayyad, Frank Kozielski, Girish A. Hampannavar, Chuin Lean Tham, Rajshekhar Karpoormath, Samukelisiwe Pretty Khathi, Muthusamy Ramesh, Cherukupalli Srinivasulu
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 36:3687-3704
Kinesin spindle protein (KSP) belongs to the kinesin superfamily of microtubule-based motor proteins. KSP is responsible for the establishment of the bipolar mitotic spindle which mediates cell division. Inhibition of KSP expedites the blockade of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622050c6d22c8f3d8370c7fffb283582
https://doi.org/10.1080/07391102.2017.1396255
https://doi.org/10.1080/07391102.2017.1396255
Autor:
Chuin Lean Tham, Samukelisiwe Pretty Khathi, Balakumar Chandrasekaran, Sivanandhan Karunanidhi, Rajshekhar Karpoormath, Nisar Sayyad, Frank Kozielski
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(17)
A novel series of 1,3,4-thiadiazole-thiazolone hybrids 5a–v were designed, synthesized, characterized, and evaluated against the basal and the microtubule (MT)-stimulated ATPase activity of Eg5. From the evaluated derivatives, 5h displayed the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a362ba2795312c109435f696cfbac76b
https://pubmed.ncbi.nlm.nih.gov/30279037
https://pubmed.ncbi.nlm.nih.gov/30279037
Autor:
Sandeep K. Talapatra, Roberto Cirilli, Balakumar Chandrasekaran, Frank Kozielski, Chuin Lean Tham, Rajshekhar Karpoormath, Simone Carradori, Paolo Guglielmi
The thiadiazole scaffold is an important core moiety in a variety of clinical drug candidates targeting a range of diseases. For example, the 2,4,5-substituted 1,3,4-thiadiazole scaffold is present in a lead compound and at least two clinical candida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d3f48c24c43fc200a6e830575a1700
http://hdl.handle.net/11573/1194382
http://hdl.handle.net/11573/1194382
Akademický článek
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Autor:
Nisar Sayyad, Chuin Lean Tham, Balakumar Chandrasekaran, Samukelisiwe Pretty Khathi, Frank Kozielski, Rajshekhar Karpoormath, Sivanandhan Karunanidhi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3489
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c2594c78c0c73b796777bdbe82689a
https://doi.org/10.1016/j.bmcl.2018.08.029
https://doi.org/10.1016/j.bmcl.2018.08.029