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A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

Autor: San Gil R; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Pascovici D; Insight Stats, Croydon Park, NSW, Australia.; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Venturato J; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Brown-Wright H; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Mehta P; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Madrid San Martin L; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wu J; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Luan W; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Chui YK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Bademosi AT; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Swaminathan S; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Naidoo S; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Berning BA; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Wright AL; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Keating SS; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia., Curtis MA; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Faull RLM; Centre for Brain Research, University of Auckland, Auckland, New Zealand.; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand., Lee JD; School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD, Australia., Ngo ST; Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, Australia., Lee A; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Morsch M; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Chung RS; Motor Neuron Disease Research Centre, Macquarie Medical School, Macquarie University, Sydney, NSW, Australia., Scotter E; School of Biological Sciences, University of Auckland, Auckland, New Zealand.; Centre for Brain Research, University of Auckland, Auckland, New Zealand., Lisowski L; Vector and Genome Engineering Facility, Children's Medical Research Institute, Westmead, NSW, Australia.; Laboratory of Molecular Oncology and Innovative Therapies, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Translational Vectorology Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, NSW, Australia., Mirzaei M; Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, North Ryde Sydney, NSW, Australia., Walker AK; Neurodegeneration Pathobiology Laboratory, Clem Jones Centre for Ageing Dementia Research, Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia. adam.walker@uq.edu.au.

Publikováno v: Nature communications [Nat Commun] 2024 Feb 19; Vol. 15 (1), pp. 1508. Date of Electronic Publication: 2024 Feb 19.