Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370S dopamine neurons

Autor: Bogetofte, Helle, Ryan, Brent J., Jensen, Pia, Schmidt, Sissel I., Vergoossen, Dana L.E., Barnkob, Mike B., Kiani, Lisa N., Chughtai, Uroosa, Heon-Roberts, Rachel, Caiazza, Maria Claudia, McGuinness, William, Márquez-Gómez, Ricardo, Vowles, Jane, Bunn, Fiona S., Brandes, Janine, Kilfeather, Peter, Connor, Jack P., Fernandes, Hugo J.R., Caffrey, Tara M., Meyer, Morten, Cowley, Sally A., Larsen, Martin R., Wade-Martins, Richard

Publikováno v: In Cell Reports 28 March 2023 42(3)

Post-translational proteomics platform identifies neurite outgrowth impairments in Parkinson’s disease GBA-N370Sdopamine neurons

Autor: Bogetofte, Helle, Ryan, Brent J., Jensen, Pia, Schmidt, Sissel I., Vergoossen, Dana L.E., Barnkob, Mike B., Kiani, Lisa N., Chughtai, Uroosa, Heon-Roberts, Rachel, Caiazza, Maria Claudia, McGuinness, William, Márquez-Gómez, Ricardo, Vowles, Jane, Bunn, Fiona S., Brandes, Janine, Kilfeather, Peter, Connor, Jack P., Fernandes, Hugo J.R., Caffrey, Tara M., Meyer, Morten, Cowley, Sally A., Larsen, Martin R., Wade-Martins, Richard

Publikováno v: Cell Reports; March 2023, Vol. 42 Issue: 3

Exome sequencing of individuals with Huntington's disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset.

Autor: McAllister B; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Donaldson J; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Binda CS; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Powell S; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Chughtai U; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Edwards G; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Stone J; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Lobanov S; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Elliston L; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Schuhmacher LN; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Rees E; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Menzies G; School of Biosciences, Cardiff University, Cardiff, UK., Ciosi M; Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UK., Maxwell A; Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UK., Chao MJ; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Hong EP; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Lucente D; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Wheeler V; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Lee JM; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., MacDonald ME; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Long JD; Departments of Psychiatry and Biostatistics, University of Iowa, Iowa City, IA, USA., Aylward EH; Seattle Children's Research Institute, Seattle, WA, USA., Landwehrmeyer GB; Department of Neurology, University of Ulm, Ulm, Germany., Rosser AE; Brain Repair Group, Schools of Medicine and Biosciences, Cardiff University, Cardiff, UK.; Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK., Paulsen JS; University of Wisconsin, Madison, WI, USA., Williams NM; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Gusella JF; Molecular Neurogenetics Unit, Center for Genomic Medicine, Massachusetts General Hospital and Department of Neurology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics Program, Broad Institute, Cambridge, MA, USA., Monckton DG; Institute of Molecular, Cell and Systems Biology, University of Glasgow, Glasgow, UK., Allen ND; School of Biosciences, Cardiff University, Cardiff, UK., Holmans P; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK., Jones L; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. jonesl1@cardiff.ac.uk.; UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. jonesl1@cardiff.ac.uk., Massey TH; Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK. masseyt1@cardiff.ac.uk.

Publikováno v: Nature neuroscience [Nat Neurosci] 2022 Apr; Vol. 25 (4), pp. 446-457. Date of Electronic Publication: 2022 Apr 04.