Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chuck Timchalk"'
Publikováno v:
Toxicology. 220:13-25
Previous studies have indicated that juvenile rats are more susceptible than adults to the acute toxicity from exposure to the organophosphorus insecticide chlorpyrifos (CPF) and age-dependent differences in metabolism and sensitivity to cholinestera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581ae99c830d4e0a2b36cc0c953a75d8
https://doi.org/10.1016/j.tox.2005.11.011
https://doi.org/10.1016/j.tox.2005.11.011
Autor:
Hong Wu, James A. Campbell, Eric W. Hoppe, Ahmed A. Kousba, Chuck Timchalk, Blandina R. Valenzuela
Publikováno v:
Analytical Letters. 38:939-949
Organophosphorus (OP) insecticides (e.g. chlorpyrifos) are widely used in a variety of applications, and the potential exists for significant occupational and environmental exposures. They have been associated with more occupational poisoning cases t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70d0dc53f4ee6c97f17a6c7003960b0b
https://doi.org/10.1081/al-200054056
https://doi.org/10.1081/al-200054056
Publikováno v:
NeuroToxicology. 25:1013-1030
Diazinon (DZN) is an organophosphorus pesticide with the possibility for widespread exposures. The toxicological effects of DZN are primarily mediated through the effects of its toxic metabolite, DZN-oxon on acetylcholinesterases, which results in ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a09b3d1803a3783093702f6a14301cd
https://doi.org/10.1016/j.neuro.2004.03.002
https://doi.org/10.1016/j.neuro.2004.03.002
Autor:
Torka S. Poet, Chuck Timchalk
Publikováno v:
Neurotoxicology. 29(3)
Physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) models have been developed for the organophosphorus (OP) insecticides chlorpyrifos (CPF) and diazinon (DZN). It is anticipated that these OPs could interact at a number of important meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d447083a1bdb5cff02e9fe03852c6ee8
https://pubmed.ncbi.nlm.nih.gov/18394709
https://pubmed.ncbi.nlm.nih.gov/18394709
Autor:
Chuck Timchalk, Torka S. Poet
A large number of volatile chemicals have been identified in the headspaces of tanks used to store mixed chemical and radioactive waste at the U.S. Department of Energy (DOE) Hanford Site, and there is concern that vapor releases from the tanks may b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3018085d3bc245f2dfce3c1c92b9ab3c
https://doi.org/10.2172/881941
https://doi.org/10.2172/881941
Autor:
Hong Wu, Yuehe Lin, Dean A. Moore, Richard A. Gies, Chuck Timchalk, Wassana Yantasee, Karl K. Weitz
Publikováno v:
Toxicology. 222(1-2)
Biological monitoring for lead (Pb) is usually based upon a determination of blood Pb concentration; however, saliva has been suggested as a non-invasive biological matrix for assessing exposure. To further evaluate the potential utility of saliva fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7287e7c1942677d95fcd05faaa9e7edb
https://pubmed.ncbi.nlm.nih.gov/16510233
https://pubmed.ncbi.nlm.nih.gov/16510233
Publikováno v:
Toxicology and applied pharmacology. 205(1)
Chlorpyrifos (CPF) and diazinon (DZN) are two commonly used organophosphorus (OP) insecticides and a potential exists for concurrent exposures. The primary neurotoxic effects from OP pesticide exposures result from the inhibition of acetylcholinester
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c85b58b2eb7510cc0fd16b51f3f8c303
https://pubmed.ncbi.nlm.nih.gov/15885262
https://pubmed.ncbi.nlm.nih.gov/15885262
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 80(2)
The primary mechanism of action for organophosphorus (OP) insecticides, like chlorpyrifos and parathion, is to inhibit acetylcholinesterase (AChE) by their oxygenated metabolites (oxons), due to the phosphorylation of the serine hydroxyl group locate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::853cb6e59fc17465363a87fb568cb8d8
https://pubmed.ncbi.nlm.nih.gov/15141101
https://pubmed.ncbi.nlm.nih.gov/15141101
Publikováno v:
Toxicology letters. 135(1-2)
Susceptibility to organophosphate (OP) insecticides, like chlorpyrifos (CPF), may result from differences in the extent of metabolic detoxification of the active metabolite, CPF-oxon. A genetic polymorphism in the arylesterase (PON1; CPF-oxonase) det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7296ef3ef04b16f98cd9855060e3a593
https://pubmed.ncbi.nlm.nih.gov/12243863
https://pubmed.ncbi.nlm.nih.gov/12243863
Autor:
R. J. Nolan, Joel L. Mattsson, Kathy A. Brzak, Chuck Timchalk, D. A. Dittenber, A. L. Mendrala
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 66(1)
A PBPK/PD model was developed for the organophosphate insecticide chlorpyrifos (CPF) (O,O-diethyl-O-[3,5,6-trichloro-2-pyridyl]-phosphorothioate), and the major metabolites CPF-oxon and 3,5,6-trichloro-2-pyridinol (TCP) in rats and humans. This model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17fde8987155ff11371d128797203b65
https://pubmed.ncbi.nlm.nih.gov/11861971
https://pubmed.ncbi.nlm.nih.gov/11861971