Zobrazeno 1 - 10
of 218
pro vyhledávání: '"Chuck T."'
Autor:
Mackenzie E. Smith, Chuck T. Chen, Chiraag A. Gohel, Giulia Cisbani, Daniel K. Chen, Kimia Rezaei, Andrew McCutcheon, Richard P. Bazinet
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Palmitic acid (PAM) can be provided in the diet or synthesized via de novo lipogenesis (DNL), primarily, from glucose. Preclinical work on the origin of brain PAM during development is scarce and contrasts results in adults. In this work, we
Externí odkaz:
https://doaj.org/article/e4692a778d024295a545b2d37ccc019a
Autor:
Daniel K. Chen, Adam H. Metherel, Kimia Rezaei, Camilla Parzanini, Chuck T. Chen, Christopher E. Ramsden, Mark Horowitz, Keturah R. Faurot, Beth MacIntosh, Daisy Zamora, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 64, Iss 9, Pp 100424- (2023)
Natural variations in the 13C:12C ratio (carbon-13 isotopic abundance [δ13C]) of the food supply have been used to determine the dietary origin and metabolism of fatty acids, especially in the n-3 PUFA biosynthesis pathway. However, n-6 PUFA metabol
Externí odkaz:
https://doaj.org/article/f8c9a912480c45c89e78253ae27c148f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Retina is rich in lipids and dyslipidemia causes retinal dysfunction and eye diseases. In retina, lipids are not only important membrane component in cells and organelles but also fuel substrates for energy production. However, our current knowledge
Externí odkaz:
https://doaj.org/article/689d7db99ab54fdca1ebe056718d987f
Autor:
Sabrina Ayoub-Charette, Néma D. McGlynn, Danielle Lee, Tauseef Ahmad Khan, Sonia Blanco Mejia, Laura Chiavaroli, Meaghan E. Kavanagh, Maxine Seider, Amel Taibi, Chuck T. Chen, Amna Ahmed, Rachel Asbury, Madeline Erlich, Yue-Tong Chen, Vasanti S. Malik, Richard P. Bazinet, D. Dan Ramdath, Caomhan Logue, Anthony J. Hanley, Cyril W. C. Kendall, Lawrence A. Leiter, Elena M. Comelli, John L. Sievenpiper
Publikováno v:
Nutrients, Vol 15, Iss 5, p 1238 (2023)
Background: Health authorities are near universal in their recommendation to replace sugar-sweetened beverages (SSBs) with water. Non-nutritive sweetened beverages (NSBs) are not as widely recommended as a replacement strategy due to a lack of establ
Externí odkaz:
https://doaj.org/article/c9adfd8289c64870a227a24dcd9443a8
Autor:
Zhongjie Fu, Wenjun Yan, Chuck T. Chen, Anders K. Nilsson, Edward Bull, William Allen, Jay Yang, Minji Ko, John Paul SanGiovanni, James D. Akula, Saswata Talukdar, Ann Hellström, Lois E. H. Smith
Publikováno v:
Nutrients, Vol 14, Iss 7, p 1333 (2022)
There is a gap in understanding the effect of the essential ω-3 and ω-6 long-chain polyunsaturated fatty acids (LCPUFA) on Phase I retinopathy of prematurity (ROP), which precipitates proliferative ROP. Postnatal hyperglycemia contributes to Phase
Externí odkaz:
https://doaj.org/article/7a0ab7c11ae040338b4a7dad9bb71a1e
Autor:
Lauren E. Lin, Chuck T. Chen, Kayla D. Hildebrand, Zhen Liu, Kathryn E. Hopperton, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 2, Pp 390-402 (2015)
To determine how the level of dietary n-6 PUFA affects the rate of loss of arachidonic acid (ARA) and DHA in brain phospholipids, male rats were fed either a deprived or adequate n-6 PUFA diet for 15 weeks postweaning, and then subjected to an intrac
Externí odkaz:
https://doaj.org/article/7b8dc25a70b04624b7311885e521a2ca
Autor:
Anthony F. Domenichiello, Chuck T. Chen, Marc-Olivier Trepanier, P.Mark Stavro, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 1, Pp 62-74 (2014)
Docosahexaenoic acid (DHA) is important for brain function, however, the exact amount required for the brain is not agreed upon. While it is believed that the synthesis rate of DHA from α-linolenic acid (ALA) is low, how this synthesis rate compares
Externí odkaz:
https://doaj.org/article/6164c38e58754e93a2685b121c67eeb7
Autor:
Chuck T. Chen, Anthony F. Domenichiello, Marc-Olivier Trépanier, Zhen Liu, Mojgan Masoodi, Richard P. Bazinet
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 9, Pp 2410-2422 (2013)
Brain eicosapentaenoic acid (EPA) levels are 250- to 300-fold lower than docosahexaenoic acid (DHA), at least partly, because EPA is rapidly β-oxidized and lost from brain phospholipids. Therefore, we examined if β-oxidation was necessary for maint
Externí odkaz:
https://doaj.org/article/478684076c734aa9a0a6ef70e6bb0cbb
Publikováno v:
Journal of Lipid Research, Vol 49, Iss 1, Pp 147-152 (2008)
The brain cannot synthesize n-6 or n-3 PUFAs de novo and requires their transport from the blood. Two models of brain fatty acid uptake have been proposed. One requires the passive diffusion of unesterified fatty acids through endothelial cells of th
Externí odkaz:
https://doaj.org/article/5eff21f7948e41cfafc5be0ba82c5213
Autor:
Kyle G. Braund, Andy Shores, Chuck T. Lowrie, H. Steven Steinberg, Michael P. Moore, Rod S. Bagley, Janet E. Steiss
Publikováno v:
Journal of Veterinary Internal Medicine, Vol 11, Iss 4, Pp 243-249 (1997)
Clinical and morphologic features of a progressive polyneuropathy in young mature Alaskan Malamutes are described. Clinical signs included progressive paraparesis, synchronous pelvic limb gait, exercise intolerance, hyperesthesia, hypore‐flexia, mu
Externí odkaz:
https://doaj.org/article/49323dfb9c4e486dbe40b07c64b846e6