Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chuck Hague"'
Autor:
Melita Dvorak-Ewell, Dan Wendt, Chuck Hague, Terri Christianson, Vish Koppaka, Danielle Crippen, Emil Kakkis, Michel Vellard
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12194 (2010)
Mucopolysaccharidosis IVA (MPS IVA; Morquio A syndrome) is a lysosomal storage disorder caused by deficiency of N-acetylgalactosamine-6-sulfatase (GALNS), an enzyme that degrades keratan sulfate (KS). Currently no therapy for MPS IVA is available. We
Externí odkaz:
https://doaj.org/article/7accaaff249d4d5483ec40f96f5417e8
Autor:
Jenna Magat, Samantha Jones, Brian Baridon, Vishal Agrawal, Hio Wong, Alexander Giaramita, Linley Mangini, Britta Handyside, Catherine Vitelli, Monica Parker, Natasha Yeung, Yu Zhou, Erno Pungor, Ilya Slabodkin, Olivia Gorostiza, Allora Aguilera, Melanie J. Lo, Saida Alcozie, Terri M. Christianson, Pascale M.N. Tiger, Jon Vincelette, Sylvia Fong, Geuncheol Gil, Chuck Hague, Roger Lawrence, Daniel J. Wendt, Jonathan H. Lebowitz, Stuart Bunting, Sherry Bullens, Brett E. Crawford, Sushmita M. Roy, Josh C. Woloszynek
Publikováno v:
Journal of Biological Chemistry. 298:102625
Mucopolysaccharidosis type IIIA (MPS IIIA) is a lysosomal storage disorder caused by N-sulfoglucosamine sulfohydrolase (SGSH) deficiency. SGSH removes the sulfate from N-sulfoglucosamine residues on the nonreducing end of heparan sulfate (HS-NRE) wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e01f4c456057e6dee1bb3611fddc2d
https://doi.org/10.1016/j.jbc.2022.102625
https://doi.org/10.1016/j.jbc.2022.102625
Autor:
Alexander Giaramita, Nathan Wise, Jon Vincelette, Rolando De Angelis, Brett E. Crawford, Sherry Bullens, Nicole Galicia, Melanie J. Lo, Jeremy L. Van Vleet, Sushmita M Roy, Gouri Yogalingam, Amanda R. Luu, Linley Mangini, Alessandra d'Azzo, Vishal Agrawal, Glenn Pacheco, Sylvia Fong, Jonathan H. LeBowitz, Terri Christianson, Hio Wong, Roger Lawrence, Britta Handyside, Harry J Sterling, Stuart Bunting, Chuck Hague, Joseph C Chen
Publikováno v:
The Journal of Biological Chemistry
Autosomal recessive mutations in the galactosidase β1 (GLB1) gene cause lysosomal β-gal deficiency, resulting in accumulation of galactose-containing substrates and onset of the progressive and fatal neurodegenerative lysosomal storage disease, GM1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1842a37d379f3461db62d067305f34f9
http://europepmc.org/articles/PMC7521651
http://europepmc.org/articles/PMC7521651
Autor:
Chuck Hague, Amanda R. Lee, Geoffrey Y. Berguig, Jonathan H. LeBowitz, Sean M. Bell, Donald S. Mackenzie, Gouri Yogalingam, Travis J. Maures, Terri Christianson, Agnes Rafalko, Heather Prill
Neutrophil myeloperoxidase (MPO) catalyzes the H2O2-dependent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent. Besides its well defined role in innate immunity, aberrant degranulation of neutrophils in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e94f5b7599bb670e8911abe281edae9
https://europepmc.org/articles/PMC5354499/
https://europepmc.org/articles/PMC5354499/
Autor:
Chuck Hague, George J. McNinch
Publikováno v:
Journal of Pure and Applied Algebra. 217:2400-2413
Let G be a connected and reductive algebraic group over an algebraically closed field of characteristic p > 0 . An interesting class of representations of G consists of those G -modules having a good filtration — i.e. a filtration whose layers are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a38fe0052d7e16226e17738335022e7
https://doi.org/10.1016/j.jpaa.2013.04.005
https://doi.org/10.1016/j.jpaa.2013.04.005
Autor:
Chuck Hague
Publikováno v:
Selecta Mathematica. 20:823-838
Recently E. Feigin introduced the $\mathbb G_a^N$-degenerations of semisimple algebraic groups and their associated degenerate flag varieties. It has been shown by Feigin, Finkelberg, and Littelmann that the degenerate flag varieties in types $A_n$ a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c9ce661c81bc0bad168b46741a7c35
https://doi.org/10.1007/s00029-013-0138-2
https://doi.org/10.1007/s00029-013-0138-2
Autor:
Chuck Hague
Publikováno v:
Journal of Algebra. 323:1758-1764
Let G be a semisimple algebraic group over an algebraically closed field of positive characteristic. In this note, we show that an irreducible closed subvariety of the flag variety of G is compatibly split by the unique canonical Frobenius splitting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e87818b3730df0f32a25db2b8a1b7f
https://doi.org/10.1016/j.jalgebra.2009.12.004
https://doi.org/10.1016/j.jalgebra.2009.12.004
Autor:
Chuck Hague
Publikováno v:
Journal of Algebra. 321:3790-3815
Let G be a reductive algebraic group over C and let N be a G-module. For any subspace M of N, the Brylinski–Kostant filtration on M is defined through the action of a principal nilpotent element in LieG. This filtration is related to a q-analog of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60fa983873f99189fb0e9c566186cbe
https://doi.org/10.1016/j.jalgebra.2009.04.001
https://doi.org/10.1016/j.jalgebra.2009.04.001
Autor:
Shih-hsin Kan, Zhi Chen, Stuart Bunting, Brett E. Crawford, Wesley Wong, Anil Bagri, Evan G. Adintori, John Holtzinger, Melanie J. Lo, Elizabeth F. Neufeld, Danielle Crippen-Harmon, Paul A. Fitzpatrick, Jillian R. Brown, Josh C. Woloszynek, Pascale M.N. Tiger, Kristen N. Vondrak, Diana S. Cheung, Kazuhiro Ohmi, Jon Vincelette, Sherry Bullens, Jonathan H. LeBowitz, Chuck Hague, Steven Q. Le, Roger Lawrence, Terri Christianson, Bryan K. Yip, Daniel J. Wendt, Katherine A. Webster, Mika Aoyagi-Scharber, Patricia I. Dickson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 41
Mucopolysaccharidosis type IIIB (MPS IIIB, Sanfilippo syndrome type B) is a lysosomal storage disease characterized by profound intellectual disability, dementia, and a lifespan of about two decades. The cause is mutation in the gene encoding α–N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6e9cef317d3d7e5f182f493e8a4dd4c
https://europepmc.org/articles/PMC4205671/
https://europepmc.org/articles/PMC4205671/
Autor:
Chuck Hague
Following the program of algebraic Frobenius splitting begun by Kumar and Littelmann, we use representation-theoretic techniques to construct a Frobenius splitting of the cotangent bundle of the flag variety of a semisimple algebraic group over an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d47a3c18ceba68c107d8468ee164977
http://arxiv.org/abs/1208.4314
http://arxiv.org/abs/1208.4314