Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Chuanzhou Li"'
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 10, Iss 9, Pp 1556-1568 (2023)
Abstract Objective Leukodystrophies are a diverse group of rare inherited disorders that affect the white matter of the central nervous system with a wide phenotypic spectrum. We aimed to characterize the clinical and genetic features of leukodystrop
Externí odkaz:
https://doaj.org/article/4a4024c06a58488fb11ca2ca7385c2f5
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers worldwide and accounts for more than 90% of primary liver cancer. The advent of immune checkpoint inhibitor (ICI)-related therapies combined with angiogenesis inhibition has revoluti
Externí odkaz:
https://doaj.org/article/16040a7d45fe49caa8087fec742e6e1f
Publikováno v:
Biomarker Research, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Galectins are animal lectins with specific affinity for galactosides via the conserved carbohydrate recognition domains. Increasing studies recently have identified critical roles of galectin family members in tumor progression. Abnormal exp
Externí odkaz:
https://doaj.org/article/2722b2dcfecc4ae8b54f4f2baa197d7f
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Externí odkaz:
https://doaj.org/article/d639b45901434482a840db75296048a3
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
BackgroundMutations in the presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) genes have been commonly identified in early-onset Alzheimer's disease (EOAD). Some of the mutations in the three causative genes, especially t
Externí odkaz:
https://doaj.org/article/55610426fffb425d890e0af66a45490c
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
X-linked Charcot-Marie-Tooth Disease type 1(CMT1X) is the second most common form of inherited peripheral neuropathy that is caused by mutations in the gap junction beta-1 (GJB1) gene. Using targeted exome-sequencing, we investigated four CMT familie
Externí odkaz:
https://doaj.org/article/6fbc44422afb473cb2f19b7b6eacd280
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Background: Aplasia cutis congenita (ACC) and terminal transverse limb defects (TTLDs) are the most common features of Adams-Oliver syndrome (AOS). ARHGAP31 is one of the causative genes for autosomal dominant forms of AOS, meanwhile its variants may
Externí odkaz:
https://doaj.org/article/0845ca5774f24cba9c36f36d0bccdb35
Autor:
Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G. Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The role of Endonuclease G in autophagy remains unclear. Here the authors report that ENDOG is released from mitochondria during starvation and promotes autophagy by suppressing mTOR signaling and activating DNA damage response.
Externí odkaz:
https://doaj.org/article/350ee72370584337b6076ca9cb427330
Publikováno v:
Vaccines, Vol 11, Iss 3, p 614 (2023)
Hepatitis B virus (HBV) infection is the main risk factor for the development of hepatocellular carcinoma (HCC), the most common type of liver cancer, with high incidence and mortality worldwide. Surgery, liver transplantation, and ablation therapies
Externí odkaz:
https://doaj.org/article/89887d73b98840418f8031da17266b29
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract In Alzheimer disease and related disorders, the microtubule-associated protein tau aggregates and forms cytoplasmic lesions that impair neuronal physiology at many levels. In addition to affecting the host neuron, tau aggregates also spread
Externí odkaz:
https://doaj.org/article/8af45514d2f84163b48c53b0d75ee398