Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chuanyuan Chen"'
Autor:
Guanghao Liang, Linchen Wang, Qiancheng You, Kirk Cahill, Chuanyuan Chen, Wei Zhang, Noreen Fulton, Wendy Stock, Olatoyosi Odenike, Chuan He, Dali Han
Publikováno v:
Advanced Science, Vol 10, Iss 23, Pp n/a-n/a (2023)
Abstract Azacitidine (AZA) is a DNA methyltransferase inhibitor and epigenetic modulator that can be an effective agent in combination with chemotherapy for patients with high‐risk acute myeloid leukemia (AML). However, biological factors driving t
Externí odkaz:
https://doaj.org/article/d8b2fe41d4644cb2b91b55fc8ee4f1f5
Autor:
Fei Teng, Jing Li, Tongtong Cui, Kai Xu, Lu Guo, Qingqin Gao, Guihai Feng, Chuanyuan Chen, Dali Han, Qi Zhou, Wei Li
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract CRISPR-Cas12a/Cpf1, a single RNA-guided endonuclease system, provides a promising tool for genome engineering. However, only three Cas12a orthologs have been employed for mammalian genome editing, and the editing efficiency as well as target
Externí odkaz:
https://doaj.org/article/ef19e2ad7d1c4c9788a858a91d36f8cb
Publikováno v:
Exp Biol Med (Maywood)
Morroniside is known to improve osteoporosis by promoting osteoblastogenesis. The activation of PI3K/Akt/mTOR signaling is a significant mechanism in morroniside-promoted osteoblastogenesis. It is well known that protective autophagy is an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e843485710b166fe996cba3bff91e99
https://doi.org/10.1177/15353702221116879
https://doi.org/10.1177/15353702221116879
Autor:
Chuan Chen, Chuan He, Chuanyuan Chen, Xiaoyang Dou, Yawei Gao, Dali Han, Siqi Zhao, Chang Liu, Bin Shen, Meng Michelle Xu, Jun Liu
Publikováno v:
Science
A new layer of transcriptional control N 6 -methyladenosine (m 6 A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m 6 A is also cotranscriptionally added onto various chromosome-associated regulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a848d2d2eb590558953218a5dc5aa5
https://doi.org/10.1126/science.aay6018
https://doi.org/10.1126/science.aay6018
Autor:
Taiping Zhang, Yi Liu, Ying Yang, Dan Guo, Menghua Dai, Wenze Wang, Yun-Gui Yang, Yong-Liang Zhao, Wenming Wu, Jialin Jiang, Yupei Zhao, Guanshen Cui, Yu-Sheng Chen, Bao-Fa Sun, Chuanyuan Chen, Quan Liao, Peng Junya, Huang Dan, Jia-Yi Zhou, Chen Hao, Dali Han, Liu Lulu, Junchao Guo
Publikováno v:
Cell Res
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer featured with high intra-tumoral heterogeneity and poor prognosis. To comprehensively delineate the PDAC intra-tumoral heterogeneity and the underlying mechanism for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82bf9e41690170b5385f8e9073a86ee
https://doi.org/10.1038/s41422-019-0195-y
https://doi.org/10.1038/s41422-019-0195-y
Autor:
Yuanyuan Liu, Renbao Chang, Xiaona Huang, Jun Liu, Chuanyuan Chen, Chuan He, Yi Liu, Ralph R. Weichselbaum, Dali Han, Marc Bissonnette, Lihui Dong, Meng Michelle Xu, Urszula Dougherty, Jianying Wang, Bin Shen
Publikováno v:
Nature. 566:270-274
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2. Despite the presence of numerous neoantigens in patients, complete t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::847d3ae6285bde8a18255ae1b8e02ba3
https://doi.org/10.1038/s41586-019-0916-x
https://doi.org/10.1038/s41586-019-0916-x
Publikováno v:
Am J Transl Res
Objective: To determine the efficacy of acupuncture around the greater tuberosity of the femur (AGTF) combined with acupuncture at Xuehai acupoint for postoperative pain in elderly patients with intertrochanteric fracture. Methods: A total of 97 elde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::12e0c98a608d1e866c22cd54ec649555
https://pubmed.ncbi.nlm.nih.gov/34377330
https://pubmed.ncbi.nlm.nih.gov/34377330
Autor:
Lihui, Dong, Chuanyuan, Chen, Yawei, Zhang, Peijin, Guo, Zhenghang, Wang, Jian, Li, Yi, Liu, Jun, Liu, Renbao, Chang, Yilin, Li, Guanghao, Liang, Weiyi, Lai, Mengxue, Sun, Urszula, Dougherty, Marc B, Bissonnette, Hailin, Wang, Lin, Shen, Meng Michelle, Xu, Dali, Han
Publikováno v:
Cancer cell. 39(7)
Tumor-associated macrophages (TAMs) can dampen the antitumor activity of T cells, yet the underlying mechanism remains incompletely understood. Here, we show that C1q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7dad5c3d0106cac0224840ebdfc8a276
https://pubmed.ncbi.nlm.nih.gov/34019807
https://pubmed.ncbi.nlm.nih.gov/34019807
Autor:
Dali Han, Guanghao Liang, Linchen Wang, Qiancheng You, Wendy Stock, Olatoyosi Odenike, Noreen Fulton, Wei Zhang, Chuan He, Chuanyuan Chen, Kirk E. Cahill
Publikováno v:
Blood. 138:1305-1305
Introduction Acute myeloid leukemia (AML) is an aggressive disease with genetic and phenotypic heterogeneity that results in a highly variable response to standard chemotherapy. Azacitidine (AZA) is a hypomethylating agent (HMA) and has been investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbec409d2494ebad3315094b872687a7
https://doi.org/10.1182/blood-2021-151951
https://doi.org/10.1182/blood-2021-151951
Autor:
Zhenghang Wang, Lin Shen, Yawei Zhang, Renbao Chang, Lihui Dong, Marc Bissonnette, Urszula Dougherty, Chuanyuan Chen, Yi Liu, Jian Li, Jun Liu, Hailin Wang, Meng Michelle Xu, Yilin Li, Weiyi Lai, Mengxue Sun, Peijin Guo, Guanghao Liang, Dali Han
Publikováno v:
Cancer Cell. 39:945-957.e10
Summary Tumor-associated macrophages (TAMs) can dampen the antitumor activity of T cells, yet the underlying mechanism remains incompletely understood. Here, we show that C1q+ TAMs are regulated by an RNA N6-methyladenosine (m6A) program and modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52900a009938f014ce8c703bea5de680
https://doi.org/10.1016/j.ccell.2021.04.016
https://doi.org/10.1016/j.ccell.2021.04.016