Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chuanjun, Shu"'
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-14 (2022)
Abstract Enhancer release and retargeting (ERR) events could activate disease-causing gene promoters for increasing the expression level of oncogenes. Meanwhile, class A orphan GPCRs (oGPCRs) are known as potential biomarkers or drug targets for vari
Externí odkaz:
https://doaj.org/article/13438ec580b94188a06c20ebceb23d86
Autor:
Lihua Zhang, Ming Chen, Shenghong Ju, Kai Lu, Bin Xu, Wenchao Li, Saisai Chen, Jianping Wu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Shuqiu Chen, Dingxiao Zhang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 4 (2023)
Background Tumor-associated macrophages are mainly polarized into the M2 phenotype, remodeling the tumor microenvironment and promoting tumor progression by secreting various cytokines.Methods Tissue microarray consisting of prostate cancer (PCa), no
Externí odkaz:
https://doaj.org/article/ec9d96f2a8754401ade1e453d7bf41d6
Autor:
Zurong Zhai, Yanlin Ren, Chuanjun Shu, Dongyin Chen, Xia Liu, Yan Liang, Aiping Li, Jianwei Zhou
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract Triple negative breast cancer (TNBC) is a type of breast cancer with poor prognosis, and has no ideal therapeutic target and ideal medicine. Downregulation of JWA is closely related to the poor overall survival in many cancers including TNBC
Externí odkaz:
https://doaj.org/article/0373b998251446bfaaae4d663c740255
Autor:
Qiang Wang, Chen Chen, Xiao Xu, Chuanjun Shu, Changchang Cao, Zhangding Wang, Yao Fu, Lei Xu, Kaiyue Xu, Jiawen Xu, Anliang Xia, Bo Wang, Guifang Xu, Xiaoping Zou, Ruibao Su, Wei Kang, Yuanchao Xue, Ran Mo, Beicheng Sun, Shouyu Wang
Publikováno v:
Advanced Science, Vol 9, Iss 28, Pp n/a-n/a (2022)
Abstract Chemotherapeutics remain the first choice for advanced gastric cancers (GCs). However, drug resistance and unavoidable severe toxicity lead to chemotherapy failure and poor prognosis. Long noncoding RNAs (lncRNAs) play critical roles in tumo
Externí odkaz:
https://doaj.org/article/d309db78ae3f4aacbdd804d62e013a10
Autor:
Kun Ding, Xuqian Jiang, Zhangding Wang, Lu Zou, Jiahua Cui, Xiong Li, Chuanjun Shu, Aiping Li, Jianwei Zhou
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8794 (2023)
Lung adenocarcinoma (LUAD) is the most common lung cancer, with high mortality. As a tumor-suppressor gene, JWA plays an important role in blocking pan-tumor progression. JAC4, a small molecular-compound agonist, transcriptionally activates JWA expre
Externí odkaz:
https://doaj.org/article/94b03332e6554c36a562fe776eb7834e
Publikováno v:
STEMedicine, Vol 1, Iss 2 (2020)
The SARS-CoV-2 outbreak has spread rapidly and widely since December 2019, and the effective drugs are urgently needed. The two key proteins, Mpro and Spike, are attractive therapy targets for developing drugs against SARS-CoV-2 infection. In this st
Externí odkaz:
https://doaj.org/article/768131049eb148198021fc8f9f6637fa
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000175 (2019)
G protein-coupled receptors (GPCRs) play an important role in physiology and disease and represent the most productive drug targets. Orphan GPCRs, with their endogenous ligands unknown, were considered a source of drug targets and consequently attrac
Externí odkaz:
https://doaj.org/article/214db71a04a94536a82cb301329efb93
Autor:
Yue, Zhou, Lei, Xu, Zhangding, Wang, Hongwen, Liu, Xiang, Zhang, Chuanjun, Shu, Meng, Zhang, Ting, Wang, Xinyun, Xu, Xiaohong, Pu, Jian, He, Pin, Wang, Yudong, Qiu, Guifang, Xu, Xiaoping, Zou, Yun, Zhu, Lei, Wang
Publikováno v:
Theranostics. 12:3911-3927
Autor:
Chuanjun Shu, Jiahua Cui, Junjie Chen, Yi Zhang, Yanlin Ren, Jin Li, Dongyin Chen, Kun Ding, Aiping Li, Ruiwen Zhang, Jingdong He, Yongqian Shu, Jianwei Zhou
Background: Because of intratumor heterogeneity, most patients with solid tumor received limit benefits from the first line regimen. The intratumor heterogeneous molecules are known to drive tumor progression, therapeutic resistance, and disease rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d94d1a08900de6d1ae1a0c9e22e3d3f
https://doi.org/10.21203/rs.3.rs-1690983/v1
https://doi.org/10.21203/rs.3.rs-1690983/v1
Autor:
Saisai Chen, Kai Lu, Yue Hou, Zonghao You, Chuanjun Shu, Xiaoying Wei, Tiange Wu, Naipeng Shi, Guangyuan Zhang, Jianping Wu, Shuqiu Chen, Lihua Zhang, Wenchao Li, Dingxiao Zhang, Shenghong Ju, Ming Chen, Bin Xu
Publikováno v:
Journal for ImmunoTherapy of Cancer. 11:e006020
BackgroundTumor-associated macrophages are mainly polarized into the M2 phenotype, remodeling the tumor microenvironment and promoting tumor progression by secreting various cytokines.MethodsTissue microarray consisting of prostate cancer (PCa), norm