Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Chuanfeng Wu"'
Autor:
David S.J. Allan, Chuanfeng Wu, Ryland D. Mortlock, Mala Chakraborty, Katayoun Rezvani, Jan K. Davidson-Moncada, Cynthia E. Dunbar, Richard W. Childs
Publikováno v:
Molecular Therapy: Oncolytics, Vol 28, Iss , Pp 74-87 (2023)
Multiple clinical trials exploring the potential of adoptive natural killer (NK) cell therapy for cancer have employed ex vivo expansion using feeder cells to obtain large numbers of NK cells. We have previously utilized the rhesus macaque model to c
Externí odkaz:
https://doaj.org/article/1edf27f82c9247a59d26f5b1e82ee10b
Autor:
Diana M. Abraham, Richard J. Lozano, Xavi Guitart, Jialiu A. Liang, Ryland D. Mortlock, Diego A. Espinoza, Xing Fan, Allen Krouse, Aylin Bonifacino, So Gun Hong, Komudi Singh, John F. Tisdale, Chuanfeng Wu, Cynthia E. Dunbar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 28, Iss , Pp 62-75 (2023)
The clonal dynamics following hematopoietic stem progenitor cell (HSPC) transplantation with busulfan conditioning are of great interest to the development of HSPC gene therapies. Compared with total body irradiation (TBI), busulfan is less toxic and
Externí odkaz:
https://doaj.org/article/176ec39311bc4cfa81822547b0f1574e
Autor:
Chuanfeng Wu, Jialiu A. Liang, Jason M. Brenchley, Taehoon Shin, Xing Fan, Ryland D. Mortlock, Diana M. Abraham, David S.J. Allan, Marvin L. Thomas, So Gun Hong, Cynthia E. Dunbar
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Tissue resident (TR) immune cells play important roles in facilitating tissue homeostasis, coordinating immune responses against infections and tumors, and maintaining immunological memory. While studies have shown these cells are distinct phenotypic
Externí odkaz:
https://doaj.org/article/27a0c53375414a609871d7f5b2f83580
Autor:
Yan Zhang, Han Zhou, Kaiyue Chu, Chuanfeng Wu, Yun Ge, Guoping Shan, Jundong Zhou, Jing Cai, Jianhua Jin, Weiyu Sun, Ying Chen, Xiaolin Huang
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThe setup accuracy plays an extremely important role in the local control of tumors. The purpose of this study is to verify the feasibility of "Sphere-Mask" Optical Positioning System (S-M_OPS) for fast and accurate setup.MethodsFrom 2016 t
Externí odkaz:
https://doaj.org/article/b9701bf6d6d54a65a88cf831cee426f0
Autor:
Sandeep K. Srivastava, Lauren L. Truitt, Chuanfeng Wu, Adam Glaser, Daniel J. Nolan, Michael Ginsberg, Diego A. Espinoza, Samson Koelle, Idalia M. Yabe, Kyung-Rok Yu, Sogun Hong, Stephanie Sellers, Allen Krouse, Aylin Bonifacino, Mark Metzger, Pradeep K. Dagur, Robert E. Donahue, Cynthia E. Dunbar, Sandhya R. Panch
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 703-715 (2021)
Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and
Externí odkaz:
https://doaj.org/article/f752637eb89a49feb1dc785c3084f549
Autor:
Ryland D. Mortlock, Chuanfeng Wu, E. Lake Potter, Diana M. Abraham, David S. J. Allan, So Gun Hong, Mario Roederer, Cynthia E. Dunbar
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The in vivo tissue distribution and trafficking patterns of natural killer (NK) cells remain understudied. Animal models can help bridge the gap, and rhesus macaque (RM) primates faithfully recapitulate key elements of human NK cell biology. Here, we
Externí odkaz:
https://doaj.org/article/34dbcd3433c44832ab86cf43b56e3e52
Autor:
Idalia M. Yabe, Lauren L. Truitt, Diego A. Espinoza, Chuanfeng Wu, Samson Koelle, Sandhya Panch, Marcus A.F. Corat, Thomas Winkler, Kyung-Rok Yu, So Gun Hong, Aylin Bonifacino, Allen Krouse, Mark Metzger, Robert E. Donahue, Cynthia E. Dunbar
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 11, Iss , Pp 143-154 (2018)
Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagen
Externí odkaz:
https://doaj.org/article/af788885a60b4f71bbaeb35e5dd381a5
Autor:
Xing Fan, Chuanfeng Wu, Lauren L. Truitt, Diego A. Espinoza, Stephanie Sellers, Aylin Bonifacino, Yifan Zhou, Stefan F. Cordes, Allen Krouse, Mark Metzger, Robert E. Donahue, Rong Lu, Cynthia E. Dunbar
Publikováno v:
Haematologica, Vol 105, Iss 7 (2020)
The classical model of hematopoietic hierarchies is being reconsidered on the basis of data from in vitro assays and single cell expression profiling. Recent experiments suggested that the erythroid lineage might differentiate directly from multipote
Externí odkaz:
https://doaj.org/article/1f235fa8346348e9a8ac9d57a0b58d6a
Autor:
Lauren L. Truitt, Di Yang, Diego A. Espinoza, Xing Fan, Daniel R. Ram, Matilda J. Moström, Dollnovan Tran, Lesli M. Sprehe, R. Keith Reeves, Robert E. Donahue, Amitinder Kaur, Cynthia E. Dunbar, Chuanfeng Wu
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Recent functional, gene expression, and epigenetic studies have suggested the presence of a subset of mature natural killer (NK) cells responsible for maintaining NK cell memory. The lack of endogenous clonal markers in NK cells impedes understanding
Externí odkaz:
https://doaj.org/article/cd238f4bc5384c8ca993c13401ddbd33
Autor:
So Gun Hong, Thomas Winkler, Chuanfeng Wu, Vicky Guo, Stefania Pittaluga, Alina Nicolae, Robert E. Donahue, Mark E. Metzger, Sandra D. Price, Naoya Uchida, Sergei A. Kuznetsov, Tina Kilts, Li Li, Pamela G. Robey, Cynthia E. Dunbar
Publikováno v:
Cell Reports, Vol 7, Iss 4, Pp 1298-1309 (2014)
Induced pluripotent stem cell (iPSC)-based cell therapies have great potential for regenerative medicine but are also potentially associated with tumorigenic risks. Current rodent models are not optimal predictors of efficiency and safety for clinica
Externí odkaz:
https://doaj.org/article/f595577c034347b8aff17b80690b5611