Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chuan-kui Jiang"'
Autor:
Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2007-2017
The characterization of HCV genome has identified various vital functional proteins involved in the life cycle of hepatitis C virus. This has resulted in many novel enzymatic targets that are potential for development of therapeutic agents. The HCV R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032
https://doi.org/10.1016/j.bmc.2013.01.024
https://doi.org/10.1016/j.bmc.2013.01.024
Autor:
Oleg Selyutin, F. George Njoroge, Qingbei Zeng, Stuart B. Rosenblum, Joseph A. Kozlowski, Mousumi Sannigrahi, Yueheng Jiang, Frank Bennett, Neng-Yang Shih, Eric Ferrari, Gopinadhan N. Anilkumar, Bancha Vibulbhan, Hsueh-Cheng Huang, Jose S. Duca, Li Wang, Pinto Patrick A, Stephen Gavalas, Haiyan Pu, Sony Agrawal, Kevin X. Chen, Charles A. Lesburg, Yuhua Huang, Tin-Yau Chan, Chuan-kui Jiang, Francisco Velazquez, Srikanth Venkatraman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:713-717
Development of SAR at the C2 position of indole lead 1 , a palm site inhibitor of HCV NS5B polymerase (NS5B IC 50 = 0.053 μM, replicon EC 50 = 4.8 μM), is described. Initial screening identified an acyl sulfonamide moiety as an isostere for the C2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74a4343432a940d8f437e79028a4cd
https://doi.org/10.1016/j.bmcl.2011.10.041
https://doi.org/10.1016/j.bmcl.2011.10.041
Publikováno v:
Clinical Immunology. 105:75-80
Purine nucleoside phosphorylase (PNP) deficiency results in an autosomal recessive immunodeficiency disease characterized by initial involvement of cellular immunity and neurological manifestations with subsequent abnormalities of humoral immunity. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fddda9b8c0550e1cacb238582ccbda7
https://doi.org/10.1006/clim.2002.5264
https://doi.org/10.1006/clim.2002.5264
Autor:
Tin-Yau Chan, Frank Bennett, David Hesk, Qingbei Zeng, Li Wang, Pinto Patrick A, Jennifer J. Gesell, Jose S. Duca, Neng-Yang Shih, Kevin X. Chen, Yuhua Huang, Bancha Vibulbhan, Yueheng Jiang, Sony Agrawal, Oleg Selyutin, Steve Sorota, Haiyan Pu, Hsueh-Cheng Huang, Joseph A. Kozlowski, Charles A. Lesburg, Francisco Velazquez, Stephen Gavalas, Cheng Li, Anilkumar G. Nair, Eric Ferrari, F. George Njoroge, Srikanth Venkatraman, Chuan-kui Jiang, Mousumi Sannigrahi, Stuart B. Rosenblum
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(24)
The discovery of lead compound 2e was described. Its covalent binding to HCV NS5B polymerase enzyme was investigated by X-ray analysis. The results of distribution, metabolism and pharmacokinetics were reported. Compound 2e was demonstrated to be pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04eb82ee6ce4c43fa35b72c72cd7bb9
https://pubmed.ncbi.nlm.nih.gov/24252545
https://pubmed.ncbi.nlm.nih.gov/24252545
Autor:
Yueheng Jiang, Frank Bennett, Eric Ferrari, Jose S. Duca, Yuhua Huang, Bancha Vibulbhan, Hsueh-Cheng Huang, Oleg Selyutin, Kevin X. Chen, F. George Njoroge, Francisco Velazquez, Stuart B. Rosenblum, Cheng Li, Neng-Yang Shih, Joseph A. Kozlowski, Charles A. Lesburg, Pinto Patrick A, Wanli Wu, Anilkumar G. Nair, Sony Agrawal, Chuan-kui Jiang, Larry Heimark, Srikanth Venkatraman, Stephen Gavalas, Qingbei Zeng
Publikováno v:
Bioorganicmedicinal chemistry. 22(1)
HCV infections are the leading causes for hepatocellular carcinoma and liver transplantation in the United States. Recent advances in drug discovery have identified direct acting antivirals which have significantly improved cure rates in patients. Cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8528b5ecd0188d3d6346727d7e5565
https://pubmed.ncbi.nlm.nih.gov/24275348
https://pubmed.ncbi.nlm.nih.gov/24275348
Autor:
Rochelle Hirschhorn, Lawrence E. Kurlandsky, Jennifer M. Puck, Maryann L. Huie, Chuan-Kui Jiang, Diana Ruixi Yang
Publikováno v:
Nature Genetics. 13:290-295
Somatic mosaicism in genetic disease generally results from a de novo deleterious mutation during embryogenesis. We now describe a somatic mosaicism due to the unusual mechanism of in vivo reversion to normal of an inherited mutation. The propositus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e0ece9577710a003779d94a2c87e12
https://doi.org/10.1038/ng0796-290
https://doi.org/10.1038/ng0796-290
I. Novel HCV NS5B polymerase inhibitors: discovery of indole 2-carboxylic acids with C3-heterocycles
Autor:
Neng Yang Shih, Hsueh-Cheng Huang, Jose S. Duca, Bancha Vibulbhan, Frank Bennett, Kevin X. Chen, Stephen Gavalas, Yueheng Jiang, Robert E. Palermo, Charles A. Lesburg, Srikanth Venkatraman, Zhiqing He, Francisco Velazquez, Nancy Butkiewicz, Li Wang, Boris Feld, Pinto Patrick A, Gopinadhan N. Anilkumar, Yuhua Huang, Stuart B. Rosenblum, Chuan Kui Jiang, Haiyan Pu, Tin Yau Chan, Eric Ferrari, George F Njoroge, Joseph A. Kozlowski, Sony Agrawal, Henry M. Vaccaro, Mousumi Sannigrahi, Qingbei Zeng, Patricia McMonagle, Oleg Selyutin
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
SAR development of indole-based palm site inhibitors of HCV NS5B polymerase exemplified by initial indole lead 1 (NS5B IC50 = 0.9 μM, replicon EC50 >100 μM) is described. Structure-based drug design led to the incorporation of novel heterocyclic mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbcde4c34dd48082f61c28f48aee1b2
https://pubmed.ncbi.nlm.nih.gov/21840715
https://pubmed.ncbi.nlm.nih.gov/21840715
Autor:
Zhiqing He, Yu-Sen Wang, Chuan-kui Jiang, Cliff C. Cheng, Xiaohua Huang, Sony Agrawal, Hsueh-Cheng Huang, Kyle A. Soucy, Gerald W. Shipps, Eric Ferrari, Daniel F. Wyss
Publikováno v:
ACS medicinal chemistry letters. 1(9)
Pyridine carboxamide-based inhibitors of the hepatitis C virus (HCV) NS5B polymerase were diversified and optimized to a variety of topologically related scaffolds. In particular, the 2-methyl nicotinic acid scaffold was developed into inhibitors wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ea798fa091790142cd49052dbb7b79
https://pubmed.ncbi.nlm.nih.gov/24900232
https://pubmed.ncbi.nlm.nih.gov/24900232
Autor:
Jack D. Bracken, Jamie Bandouveres, Noriyuki Kawahata, Gerald W. Shipps, Eric Ferrari, Zhiwei Yang, Chuan-kui Jiang, Jose S. Duca, Cliff C. Cheng, Sony Agrawal, Hsueh-Cheng Huang, Charles A. Lesburg
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
SAR exploration from an initial hit, (S)-N-(2-cyclohexenylethyl)-2-fluoro-6-(2-(1-hydroxy-3-phenylpropan-2-ylamino)-2-oxoethoxy)benzamide (1), identified using our proprietary automated ligand identification system (ALIS), 1 has led to a novel series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7945f7dbbd51543952736660d977fc0
https://pubmed.ncbi.nlm.nih.gov/20219368
https://pubmed.ncbi.nlm.nih.gov/20219368
Functional Comparison of the Upstream Regulatory DNA Sequences of Four Human Epidermal Keratin Genes
Publikováno v:
Journal of Investigative Dermatology. 96(2):162-167
The promoters of epidermal keratin genes, K5, K6, and K10 were cloned and their functions compared with that of the previously described promoter of the K14 keratin gene in non-epithelial and transformed epithelial cell lines, as well as in primary c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc597b1db602819ed3990c7ece2794e2