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pro vyhledávání: '"Chuan-Yuan Chang"'
Autor:
Zeljko M. Prijovich, W. Schechinger, Kai-Chuan Chen, Chia-Hung Wu, Steve R. Roffler, Yen-Chywan Liaw, Qingzong Tseng, Wei-Cheng Lu, Chuan-Yuan Chang, Yu-Lin Leu
Publikováno v:
Chemistry & Biology. 15:1277-1286
Human beta-glucuronidase, due to low intrinsic immunogenicity in humans, is an attractive enzyme for tumor-specific prodrug activation, but its utility is hindered by low activity at physiological pH. Here we describe the development of a high-throug