Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Chuan-Ming Xie"'
Autor:
Xun Li, Cheng-Cheng Zhang, Xiao-Tong Lin, Jie Zhang, Yu-Jun Zhang, Hong-Qiang Yu, Ze-Yu Liu, Yi Gong, Lei-Da Zhang, Chuan-Ming Xie
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 1, Pp 177-191 (2024)
Abstract Dysregulation of wild-type p53 turnover is a key cause of hepatocellular carcinoma (HCC), yet its mechanism remains poorly understood. Here, we report that WD repeat and SOCS box containing protein 2 (WSB2), an E3 ubiquitin ligase, is an ind
Externí odkaz:
https://doaj.org/article/2c7fc086db7d42de8764d2dbdedb0c80
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-21 (2023)
Abstract Background Kirsten rat sarcoma (KRAS) and mutant KRASG12D have been implicated in human cancers, but it remains unclear whether their activation requires ubiquitination. This study aimed to investigate whether and how F-box and leucine-rich
Externí odkaz:
https://doaj.org/article/d151a4fc625b4a2e88890dd81e3f9729
Autor:
Jie Zhang, Xiao-Tong Lin, Hong-Qiang Yu, Lei Fang, Di Wu, Yuan-Deng Luo, Yu-Jun Zhang, Chuan-Ming Xie
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2281-2286 (2023)
Externí odkaz:
https://doaj.org/article/d2459e6d198d4d6e825f12c6a08b3f39
Autor:
Jie Zhang, Xiao-Tong Lin, Hong-Qiang Yu, Lei Fang, Di Wu, Yuan-Deng Luo, Yu-Jun Zhang, Chuan-Ming Xie
Publikováno v:
Experimental and Molecular Medicine, Vol 55, Iss 10, Pp 2162-2176 (2023)
Abstract Metastatic hepatocellular carcinoma (HCC) is the most lethal malignancy and lacks effective treatment. FBXL6 is overexpressed in human hepatocellular carcinoma (HCC), but whether this change drives liver tumorigenesis and lung metastasis in
Externí odkaz:
https://doaj.org/article/41ed2f7d1856484f91e86601fcf0dbbc
Autor:
Xiao-Tong Lin, Jie Zhang, Ze-Yu Liu, Di Wu, Lei Fang, Chun-Ming Li, Hong-Qiang Yu, Chuan-Ming Xie
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112812- (2023)
Summary: Hepatocellular carcinoma (HCC), the most common liver cancer, occurs mainly in men, but the underlying mechanism remains to be further explored. Here, we report that ubiquitinated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is responsib
Externí odkaz:
https://doaj.org/article/0992248c1e2047dd80432990e087a50f
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102199- (2023)
Summary: E3 ubiquitin ligases play a role in protein degradation, cellular localization, and activation, and their dysregulation is associated with human diseases. Here, we present a protocol to detect IGF2BP1 ubiquitination and activation by an E3 u
Externí odkaz:
https://doaj.org/article/c0acbd21f7084ba98fa269fb44b97111
Autor:
Chun-Ming Li, Jie Zhang, Wu Wu, Zhu Zhu, Feng Li, Di Wu, Xiao-Jun Wang, Chuan-Ming Xie, Jian-Ping Gong
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Background and AimsAbnormal expression of E3 ubiquitin ligase plays an important role in the development and progression of hepatocellular carcinoma (HCC), although the mechanism has remained elusive. This study aimed to investigate the biological fu
Externí odkaz:
https://doaj.org/article/f3e3f99467c145ca925b26e5a563b83f
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102124- (2023)
Summary: FBXO45, an E3 ubiquitin ligase highly expressed in liver tumors, is positively correlated with poor survival of hepatocellular carcinogenesis (HCC) patients, but whether FBXO45 drives HCC tumorigenesis remains largely unclear. Here, we descr
Externí odkaz:
https://doaj.org/article/c3339c244e2c4d3ba0d3ea1e0d925448
Autor:
Yuan‐Deng Luo, Hong‐Qiang Yu, Xiao‐Yu Liu, Deng Huang, Hai‐Su Dai, Lei Fang, Yu‐Jun Zhang, Jie‐Juan Lai, Yan Jiang, Ling Shuai, Lei‐Da Zhang, Geng Chen, Ping Bie, Chuan‐Ming Xie
Publikováno v:
Cancer Medicine, Vol 9, Iss 12, Pp 4083-4094 (2020)
Abstract Purpose Hepatocellular carcinoma (HCC) is a common malignant cancer and the third leading cause of death worldwide. The molecular mechanism of HCC remains unclear. Recent studies have demonstrated that the ubiquitin‐proteasome system (UPS)
Externí odkaz:
https://doaj.org/article/3acd50238a3f44eaba329814ac32cc5f
Autor:
Di Wu, Hong-Qiang Yu, Hao-Jun Xiong, Yu-Jun Zhang, Xiao-Tong Lin, Jie Zhang, Wu Wu, Teng Wang, Xiao-Yu Liu, Chuan-Ming Xie
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
The sodium pump α3 subunit is associated with colorectal liver metastasis. However, the underlying mechanism involved in this effect is not yet known. In this study, we found that the expression levels of the sodium pump α3 subunit were positively
Externí odkaz:
https://doaj.org/article/7776092030c84bd58743d561dfa6b0f1