Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Chuan‐Fa Liu"'
Autor:
Shining Loo, Antony Kam, Bamaprasad Dutta, Xiaohong Zhang, Nan Feng, Siu Kwan Sze, Chuan-Fa Liu, Xiaoliang Wang, James P. Tam
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 2, Pp 653-666 (2024)
Stress and illness connection is complex and involves multiple physiological systems. Panax ginsengs, reputed for their broad-spectrum “cure-all” effect, are widely prescribed to treat stress and related illnesses. However, the identity of ginsen
Externí odkaz:
https://doaj.org/article/2d32b34c63674ff9b48d2c7783da2f7e
Autor:
Seetharamsing Balamkundu, Chuan-Fa Liu
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3080 (2023)
Antibody–drug Conjugates (ADCs) are a powerful therapeutic modality for cancer treatment. ADCs are multi-functional biologics in which a disease-targeting antibody is conjugated to an effector payload molecule via a linker. The success of currently
Externí odkaz:
https://doaj.org/article/5306da6e88a14aa28beb3e7eab36fc10
Site-Specific Protein Modifications by an Engineered Asparaginyl Endopeptidase from Viola canadensis
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
Asparaginyl endopeptidases (AEPs) or legumains are Asn/Asp (Asx)-specific proteases that break peptide bonds, but also function as peptide asparaginyl ligases (PALs) that make peptide bonds. This ligase activity can be used for site-specific protein
Externí odkaz:
https://doaj.org/article/b5d6df3e4f294669b34f9ddc3fd316df
Autor:
Deepti Sharma, Louis De Falco, Sivaraman Padavattan, Chang Rao, Susana Geifman-Shochat, Chuan-Fa Liu, Curt A. Davey
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand break
Externí odkaz:
https://doaj.org/article/c4b2c946501c463c9cc98da888f89daf
Autor:
Henrike Klinker, Felix Mueller-Planitz, Renliang Yang, Ignasi Forné, Chuan-Fa Liu, Lars Nordenskiöld, Peter B Becker
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88411 (2014)
ISWI is the catalytic subunit of several ATP-dependent chromatin remodelling factors that catalyse the sliding of nucleosomes along DNA and thereby endow chromatin with structural flexibility. Full activity of ISWI requires residues of a basic patch
Externí odkaz:
https://doaj.org/article/5a3705fa6d1a4035903bf9dbaeda5073
Autor:
Shining Loo, Antony Kam, Bamaprasad Dutta, Xiaohong Zhang, Nan Feng, Siu Kwan Sze, Chuan-Fa Liu, Xiaoliang Wang, James P. Tam
Ginseng has been known as a “cure-all” traditional medicine to treat various illnesses and as an adaptogen to relieve stress. However, the known active compounds of ginseng are small-molecule metabolites. Here we report ginsentides, which are dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38875b74c1ba0e1d77f732ba7d34e52d
https://doi.org/10.1101/2023.04.05.535784
https://doi.org/10.1101/2023.04.05.535784
Publikováno v:
FEBS Open Bio.
Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell-surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large p
Autor:
Yiyin Xia, Fupeng Li, Xiaohong Zhang, Seetharamsing Balamkundu, Fan Tang, Side Hu, Julien Lescar, James P. Tam, Chuan-Fa Liu
Enzymatic peptide ligation holds great promise in the study of protein functions and development of protein therapeutics. Owing to their high catalytic efficiency and a minimal tripeptide recognition motif, peptidyl asparaginyl ligases (PALs) are par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2815ca7450ad5dfe57d54e2fdda4e7ad
https://hdl.handle.net/10356/169065
https://hdl.handle.net/10356/169065
Autor:
Side Hu, Seetharamsing Balamkundu, James P. Tam, Heng Tai Liew, Janet To, Xiaohong Zhang, Julien Lescar, Chuan-Fa Liu, Surajit Bhattacharjya, Ning-Yu Chan, Yiyin Xia
Publikováno v:
Angewandte Chemie. 133:22381-22385
Peptidyl asparaginyl ligases (PALs) are powerful tools for peptide macrocyclization. Herein, we report that a derivative of Asn, namely Nγ -hydroxyasparagine or Asn(OH), is an unnatural P1 substrate of PALs. By Asn(OH)-mediated cyclization, we prepa
Autor:
Xinya Hemu, Ning‐Yu Chan, Heng Tai Liew, Side Hu, Xiaohong Zhang, Aida Serra, Julien Lescar, Chuan‐Fa Liu, James P. Tam
Peptide asparaginyl ligases (PALs) are Asn/Asp(Asx)-specific ligases that are useful for precision modifications of proteins and live-cell surfaces. PALs share high sequence and structural similarity to legumains, asparaginyl endopeptidases (AEPs) th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2534085a5de724bc7d6e550d09b33d19
https://doi.org/10.1101/2022.09.26.509423
https://doi.org/10.1101/2022.09.26.509423