Caspase-8-driven apoptotic and pyroptotic crosstalk causes cell death and IL-1β release in X-linked inhibitor of apoptosis (XIAP) deficiency.

Autor: Hughes SA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Lin M; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China.; State Key Laboratory of Respiratory Medicine, Guangzhou Medical University, Guangzhou, China., Weir A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Huang B; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China., Xiong L; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China., Chua NK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Pang J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Santavanond JP; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic, Australia., Tixeira R; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic, Australia., Doerflinger M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Deng Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Yu CH; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Silke N; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Conos SA; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Vic, Australia., Frank D; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Simpson DS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Lawlor KE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia.; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, Vic, Australia., Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Vic, Australia.; Department of Microbiology, Monash University, Clayton, Vic, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Pellegrini M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Poon IKH; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Vic, Australia., Masters SL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Li M; Department of Gastroenterology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Tang Q; The First Affiliated hospital of Guangxi Medical University, Nanning, China., Zhang Y; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China.; State Key Laboratory of Respiratory Medicine, Guangzhou Medical University, Guangzhou, China., Rashidi M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia., Geng L; Department of Gastroenterology, Guangzhou Women and Children's Medical Center, Guangzhou, China.; State Key Laboratory of Respiratory Medicine, Guangzhou Medical University, Guangzhou, China., Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.; The Department of Medical Biology, University of Melbourne, Parkville, Vic, Australia.

Publikováno v: The EMBO journal [EMBO J] 2023 Mar 01; Vol. 42 (5), pp. e110468. Date of Electronic Publication: 2023 Jan 17.

Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin.

Autor: Ho GY; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The Royal Women's Hospital, Parkville, Victoria, Australia., Kyran EL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Research UK Cambridge Institute, Cambridge, United Kingdom., Bedo J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; School of Computing and Information Systems, the University of Melbourne, Parkville, Victoria, Australia., Wakefield MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia., Ennis DP; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Mirza HB; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom., Vandenberg CJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lieschke E; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Farrell A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Hadla A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Lim R; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Dall G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chua NK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Kondrashova O; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia., Upstill-Goddard R; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Bailey UM; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Dowson S; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Roxburgh P; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Glasspool RM; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Bryson G; Department of Pathology, Queen Elizabeth University Hospital, Glasgow, United Kingdom., Biankin AV; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Cooke SL; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom., Ratnayake G; The Royal Women's Hospital, Parkville, Victoria, Australia., McNally O; The Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Traficante N; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., DeFazio A; Centre for Cancer Research, The Westmead Institute for Medical Research, Sydney, Australia.; The Daffodil Centre, The University of Sydney, A Joint Venture with Cancer Council NSW, Sydney, Australia.; Department of Gynaecological Oncology, Westmead Hospital, Sydney, Australia., Weroha SJ; Department of Oncology, Mayo Clinic, Rochester, Minnesota., Bowtell DD; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., McNeish IA; Division of Cancer and Ovarian Cancer Action Research Centre, Department of Surgery and Cancer, Imperial College London, London, United Kingdom.; Institute of Cancer Sciences, Wolfson Wohl Cancer Research Centre, University of Glasgow, Glasgow, United Kingdom.; Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom., Papenfuss AT; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Research Division, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Scott CL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; The Royal Women's Hospital, Parkville, Victoria, Australia.; Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.; Sir Peter MacCallum Cancer Centre Department of Oncology, University of Melbourne, Parkville, Victoria, Australia., Barker HE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.

Publikováno v: Cancer research [Cancer Res] 2022 Dec 02; Vol. 82 (23), pp. 4457-4473.

Reduction of Squalene Epoxidase by Cholesterol Accumulation Accelerates Colorectal Cancer Progression and Metastasis.

Autor: Jun SY; Medical Genomics Research Center, Daejon, Korea; Functional Genomics, University of Science and Technology, Daejeon, Korea., Brown AJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Chua NK; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, Australia., Yoon JY; Medical Genomics Research Center, Daejon, Korea., Lee JJ; Medical Genomics Research Center, Daejon, Korea., Yang JO; Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea., Jang I; Korean Bioinformation Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea., Jeon SJ; Medical Genomics Research Center, Daejon, Korea; Functional Genomics, University of Science and Technology, Daejeon, Korea., Choi TI; Department of Biology, Chungnam National University, Daejeon, Korea., Kim CH; Department of Biology, Chungnam National University, Daejeon, Korea., Kim NS; Medical Genomics Research Center, Daejon, Korea; Functional Genomics, University of Science and Technology, Daejeon, Korea. Electronic address: nskim37@kribb.re.kr.

Publikováno v: Gastroenterology [Gastroenterology] 2021 Mar; Vol. 160 (4), pp. 1194-1207.e28. Date of Electronic Publication: 2020 Sep 15.

SQLE—a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration.

Autor: Zhao, Yue-Chen^1,2 (AUTHOR), Li, Yun-Feng¹ (AUTHOR), Qiu, Ling¹ (AUTHOR), Jin, Shun-Zi² (AUTHOR), Shen, Yan-Nan² (AUTHOR), Zhang, Chao-He³ (AUTHOR), Cui, Jie¹ (AUTHOR), Wang, Tie-Jun^1,2 (AUTHOR) tjwang@jlu.edu.cn

Publikováno v: BMC Cancer. 9/11/2024, Vol. 24 Issue 1, p1-21. 21p.

Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24-dehydrocholesterol reductase.

Autor: Simonen P; From the, Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Li S; Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Chua NK; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia., Lampi AM; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland., Piironen V; Department of Food and Nutrition, University of Helsinki, Helsinki, Finland., Lommi J; From the, Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Sinisalo J; From the, Heart and Lung Center, Cardiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland., Brown AJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, Australia., Ikonen E; Department of Anatomy and Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Gylling H; University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Publikováno v: Journal of internal medicine [J Intern Med] 2020 Nov; Vol. 288 (5), pp. 560-569. Date of Electronic Publication: 2020 Jun 09.