Commercial AHAS-inhibiting herbicides are promising drug leads for the treatment of human fungal pathogenic infections

Autor: Garcia, Mario D., Chua, Sheena M. H., Low, Yu-Shang, Lee, Yu-Ting, Agnew-Francis, Kylie, Wang, Jian-Guo, Nouwens, Amanda, Lonhienne, Thierry, Williams, Craig M., Fraser, James A., Guddat, Luke W.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, 2018 Oct 01. 115(41), E9649-E9658.

Externí odkaz: https://www.jstor.org/stable/26532228

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AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans.

Autor: Wizrah, Maha S. I.^1,2, Chua, Sheena M. H.^1,2, Zhenyao Luo^2,3, Manik, Mohammad K.^1,2,3, Mengqi Pan^1,2,3, Whyte, Jessica M. L.^1,2, Robertson, Avril A. B.^1,2,3, Kappler, Ulrike^1,2, Kobe, Bostjan^1,2,3, Fraser, James A.^1,2 j.fraser1@uq.edu.au

Publikováno v: Journal of Biological Chemistry. Oct2022, Vol. 298 Issue 10, p1-13. 13p.

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Effective parallel evaluation of molecular design, expression and bioactivity of novel recombinant butyrylcholinesterase medical countermeasures.

Autor: Allard JL; Chemical, Biological, Radiological and Nuclear Defence Branch, Defence Science and Technology Group (DSTG), Victoria, 3027, Australia; Protein Expression Facility, The University of Queensland, Brisbane, 4072, Australia. Electronic address: joanne.allard1@defence.gov.au., Aguirre M; Protein Expression Facility, The University of Queensland, Brisbane, 4072, Australia., Gupta R; Chemical, Biological, Radiological and Nuclear Defence Branch, Defence Science and Technology Group (DSTG), Victoria, 3027, Australia., Chua SMH; Protein Expression Facility, The University of Queensland, Brisbane, 4072, Australia., Shields KA; Chemical, Biological, Radiological and Nuclear Defence Branch, Defence Science and Technology Group (DSTG), Victoria, 3027, Australia., Lua LHL; Protein Expression Facility, The University of Queensland, Brisbane, 4072, Australia.

Publikováno v: Chemico-biological interactions [Chem Biol Interact] 2024 Nov 01; Vol. 403, pp. 111219. Date of Electronic Publication: 2024 Aug 31.