Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Chua, Chu Chang"'
Publikováno v:
ETSU Faculty Works.
To test whether the antiapoptotic protein Bcl-2 prevents apoptosis and injury of cardiomyocytes after ischemia-reperfusion (I/R), we generated a line of transgenic mice that carried a human Bcl-2 transgene under the control of a mouse α-myosin heavy
Externí odkaz:
https://dc.etsu.edu/etsu-works/19167
Autor:
Liu, Xuwan, Chen, Zhongyi, Chua, Chu Chang, Ma, Yan Shan, Youngberg, George A., Hamdy, Ronald, Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
The present study was designed to explore the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultras
Externí odkaz:
https://dc.etsu.edu/etsu-works/18961
Autor:
Chua, Chu Chang, Gao, Jinping, Ho, Ye Shih, Xiong, Ye, Xu, Xingshun, Chen, Zhongyi, Hamdy, Ronald C., Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
Inhibitors of apoptosis proteins (IAPs) are key intrinsic regulators of caspases-3 and -7. During ischemia, IAP-2 is upregulated dramatically, while the other IAPs show little or no change. To test whether IAP-2 prevents cardiac apoptosis and injury
Externí odkaz:
https://dc.etsu.edu/etsu-works/17844
Autor:
Gao, Jinping, Xiong, Ye, Ho, Ye Shih, Liu, Xuwan, Chua, Chu Chang, Xu, Xingshun, Wang, Hong, Hamdy, Ronald, Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide anion radicals (superoxide) from redox cycling of DOX in cardiomyocyte mitochondria. Reduction of superoxide generates H2O2, which diffuses throughout
Externí odkaz:
https://dc.etsu.edu/etsu-works/17504
Autor:
Xu, Xingshun, Chua, Chu Chang, Gao, Jinping, Chua, Kao Wei, Wang, Hong, Hamdy, Ronald C., Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
Humanin (HN) is an anti-apoptotic peptide that suppresses neuronal cell death induced by Alzheimer's disease, prion protein fragments, and serum deprivation. Recently, we demonstrated that Gly14-HN (HNG), a variant of HN in which the 14th amino acid
Externí odkaz:
https://dc.etsu.edu/etsu-works/17412
Publikováno v:
ETSU Faculty Works.
Transforming growth factor-β1 (TGF-β1), an abundant growth factor in bone matrix, has been shown to be involved in bone formation and fracture healing. The mechanism of action of the osteogenic effect of TGF-β1 is not clearly understood. In this s
Externí odkaz:
https://dc.etsu.edu/etsu-works/14530
Publikováno v:
ETSU Faculty Works.
The dose- and time dependence of melatonin and the effective window of melatonin administration were determined in a mouse model of myocardial infarction. When mouse hearts were subjected to 60 min of occlusion of the left anterior descending artery
Externí odkaz:
https://dc.etsu.edu/etsu-works/14009
Publikováno v:
ETSU Faculty Works.
Glucocorticoids are widely used as anti-inflammatory and chemotherapeutic agents. However, prolonged use of glucocorticoids leads to osteoporosis. This study was designed to examine the mechanism of dexamethasone (DEX)-induced apoptosis in murine ost
Externí odkaz:
https://dc.etsu.edu/etsu-works/13980
Publikováno v:
ETSU Faculty Works.
Hydrogen peroxide (H2O2) is a reactive oxygen species generated by several metabolic pathways in mammalian cells. Endothelial cells are extremely susceptible to oxidative stress. H2O2 has been reported to increase the permeability in these cells. Usi
Externí odkaz:
https://dc.etsu.edu/etsu-works/13453
Publikováno v:
ETSU Faculty Works.
Thromboxane A2 (TXA2) and ET-1 have been known to play important roles in modulating vascular contraction and growth. The present study was undertaken to examine the effect of TXA2 on the induction of endothelin-1 (ET-1) mRNA and protein levels in sm
Externí odkaz:
https://dc.etsu.edu/etsu-works/12822