Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Chua, Balvin H.L"'
Autor:
Zhu, Jiangtao, Wu, Di, Zhao, Chenyu, Luo, Man, Hamdy, Ronald C., Chua, Balvin H.L., Xu, Xingshun, Miao, Zhigang
Publikováno v:
ETSU Faculty Works.
The original version of this article unfortunately contained a mistake. The presentation of x-axis coordinates of Fig. 5A (ATP level) is wrong. The corrected Fig. 5 is given below.
Externí odkaz:
https://dc.etsu.edu/etsu-works/10794
Publikováno v:
ETSU Faculty Works.
To test whether the antiapoptotic protein Bcl-2 prevents apoptosis and injury of cardiomyocytes after ischemia-reperfusion (I/R), we generated a line of transgenic mice that carried a human Bcl-2 transgene under the control of a mouse α-myosin heavy
Externí odkaz:
https://dc.etsu.edu/etsu-works/19167
Publikováno v:
ETSU Faculty Works.
Our previous work in cultured cells has shown that the maintenance of mitochondrial Ca2+ homeostasis is essential for cell survival, and that the anti-apoptotic protein Bcl-2 is able to maintain a threshold level of mitochondrial Ca2+ by the inhibiti
Externí odkaz:
https://dc.etsu.edu/etsu-works/19161
Autor:
Liu, Xuwan, Chen, Zhongyi, Chua, Chu Chang, Ma, Yan Shan, Youngberg, George A., Hamdy, Ronald, Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
The present study was designed to explore the protective effects of melatonin and its analogs, 6-hydroxymelatonin and 8-methoxy-2-propionamidotetralin, on the survival of doxorubicin-treated mice and on doxorubicin-induced cardiac dysfunction, ultras
Externí odkaz:
https://dc.etsu.edu/etsu-works/18961
Autor:
Vulapalli, Sreesatya Raju, Chen, Zhongyi, Chua, Balvin H.L., Wang, Tingchung, Liang, Chang Seng
Publikováno v:
ETSU Faculty Works.
Heme oxygenase (HO)-1 converts heme to bilirubin, carbon monoxide, and iron. Our prior work has suggested a cardioprotective role for HO-1 in heart failure. To test whether HO-1 (heat shock protein 32) prevents cardiomyocyte apoptosis and cardiac dys
Externí odkaz:
https://dc.etsu.edu/etsu-works/18962
Publikováno v:
ETSU Faculty Works.
Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine that induces apoptosis in a number of cell systems, including osteoblasts. Transforming growth factor β1 (TGF-β1) is an abundant growth factor that is known to stimulate bone formation
Externí odkaz:
https://dc.etsu.edu/etsu-works/18938
Autor:
Liu, Xuwan, Chua, Chu C., Gao, Jinping, Chen, Zhongyi, Landy, Cathy L.C., Hamdy, Ronald, Chua, Balvin H.L.
Publikováno v:
ETSU Faculty Works.
The present experiments were designed to evaluate the effects of pifithrin-α (PFT-α), which is a p53 inhibitor, on doxorubicin (DOX)-induced apoptosis and cardiac injury. Administration of DOX (22.5 mg/kg ip) in mice upregulated the mRNA levels of
Externí odkaz:
https://dc.etsu.edu/etsu-works/18729
Publikováno v:
ETSU Faculty Works.
The cardiac toxicity of doxorubicin (DOX), a potent anticancer anthracycline antibiotic, is believed to be mediated through the generation of reactive oxygen species (ROS) in cardiomyocytes. This study aims to determine the function of cellular gluta
Externí odkaz:
https://dc.etsu.edu/etsu-works/18201
Publikováno v:
ETSU Faculty Works.
Doxorubicin (Dox) is a chemotherapeutic agent that causes significant cardiotoxicity. We showed previously that Dox activates p53 and induces apoptosis in mouse hearts. This study was designed to elucidate the molecular events that lead to p53 stabil
Externí odkaz:
https://dc.etsu.edu/etsu-works/18180
Publikováno v:
ETSU Faculty Works.
BACKGROUND AND PURPOSE - Humanin (HN) is a 24-amino acid peptide best known for its ability to protect neurons from damage caused by Alzheimer disease-related proteins. This study examines the neuroprotective effects of HNG (a potent form of HN) on f
Externí odkaz:
https://dc.etsu.edu/etsu-works/18121