Výsledky vyhledávání - "Chu-lai Hsiao"

Structure-Based Design of Estrogen Receptor-β Selective Ligands

Autor: Chu-Lai Hsiao, Ramesh A. Bhat, Rayomand J Unwalla, Zhang B. Xu, Karl Malakian, William S. Somers, Tatos N. Akopian, Wah-Tung Hum, Heather A. Harris, Eric S. Manas, Michael S. Malamas, Juan C. Alvarez, Ashok R. Bapat, Scott Wolfrom, Chris P. Miller, Mark Stahl

Publikováno v: Journal of the American Chemical Society. 126:15106-15119

We present the structure-based optimization of a series of estrogen receptor-beta (ERbeta) selective ligands. X-ray cocrystal structures of these ligands complexed to both ERalpha and ERbeta are described. We also discuss how molecular modeling was u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8fb882810df1e98eddbab62daae6f1a
https://doi.org/10.1021/ja047633o

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Catalytically Active MAP KAP Kinase 2 Structures in Complex with Staurosporine and ADP Reveal Differences with the Autoinhibited Enzyme

Autor: Kristine Svenson, Kevin D. Parris, Robert M. Czerwinski, Elizabeth Federico, Scott Wolfrom, Jasbir Seehra, Jean-Baptiste Telliez, William S. Somers, Michelle Maguire, Karl Malakian, Mark Stahl, Ronald W. Kriz, Kathryn W. Underwood, Chu-Lai Hsiao, Tania Shane, Lih-Ling Lin, Meggin Taylor, Yan Liu, Lidia Mosyak

Publikováno v: Structure. 11(6):627-636

MAP KAP kinase 2 (MK2), a Ser/Thr kinase, plays a crucial role in the inflammatory process. We have determined the crystal structures of a catalytically active C-terminal deletion form of human MK2, residues 41–364, in complex with staurosporine at

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097acf64f2226a080302c56bfbe63f41

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Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases

Autor: Frances C. Nelson, Pranab K. Chanda, Gu Yansong, Michele A. Sharr, John F. DiJoseph, Jerauld S. Skotnicki, Jeremy I. Levin, Rebecca Cowling, Arie Zask, Chu-Lai Hsiao, Scott Cosmi, Amy Sung, Wade Edris, Loran M. Killar, James M. Wilhelm, Guixian Jin

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:239-242

Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324268ed9ef83042163a444908494a13
https://doi.org/10.1016/s0960-894x(00)00644-2

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Etodolac selectively inhibits human prostaglandin G/H synthase 2 (PGHS-2) versus human PGHS-1

Autor: Mei-Li Sung, Chu-Lai Hsiao, Kim O'Neill, R. P. Carlson, B. M. Weichman, Dennis Kubrak, Keith B. Glaser, D. A. Hartman, Mary Belfast, Anthony F. Kreft

Publikováno v: European Journal of Pharmacology. 281:107-111

The isozymes of prostaglandin G/H synthase (PGHS) are shown to be differentially inhibited in vitro by currently marketed nonsteroidal anti-inflammatory drugs (NSAIDs) using microsomal rhPGHS-1 and rhPGHS-2. Comparison of selectivity ratios (IC50 rhP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e712b3e4f95d9b69c8237e9670751751
https://doi.org/10.1016/0014-2999(95)00302-2

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Immunogenicity of recombinant influenza virus haemagglutinin carrying peptides from the envelope protein of human immunodeficiency virus type 1

Autor: Paul P. Hung, Alan R. Davis, Michael R. Pisano, Jorg W. Eichberg, Shaw-Guang Lee, Narender K. Kalyan, Marjorie Robert-Guroff, Wah-Tung Hum, Chu-Lai Hsiao, James M. Wilhelm

Publikováno v: Vaccine. 12(8)

Haemagglutinin (HA), the major surface glycoprotein of influenza virus, is a potent immunogen against which viral neutralizing antibodies are directed. Studies of the three-dimensional structure of HA have identified major antigenic sites on the mole

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320c132266f4d2842d496c880e6d613d
https://pubmed.ncbi.nlm.nih.gov/7522383

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Identification and properties of bacteriophage T4 capsid-formation gene products

Autor: Patricia J. Coon, Lindsay W. Black, Carlos J. Castillo, Chu-Lai Hsiao

Publikováno v: Journal of Molecular Biology. 110:585-601

The previously unidentified products of the remainder of those genes ( Y -genes) known to be essential for bacteriophage T4 capsid formation (genes 21, 31 and 40 ) have been identified by sodium dodecyl sulfate/urea/acrylamide gradient gel electropho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df683b544ee5e908cffc303df9226a8a
https://doi.org/10.1016/s0022-2836(77)80113-7

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Direct selection procedure for the isolation of functional centromeric DNA

Autor: Chu-Lai Hsiao, John Carbon

Publikováno v: Proceedings of the National Academy of Sciences. 78:3760-3764

Several plasmids, each containing a segment of DNA capable of conferring mitotic stability on the ars1 vector YRp7 replicating in yeast (Saccharomyces cerevisiae), have been isolated from a yeast genomic library by direct selection for stable plasmid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5fcdb555c35c5e2927ebe38cb1c21a
https://doi.org/10.1073/pnas.78.6.3760

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Expression of hepatitis B surface antigen with a recombinant adenovirus

Autor: Beverley Kostek, Chu-Lai Hsiao, Bruce B. Mason, Paul P. Hung, Surendra K. Dheer, John Morin, Alan R. Davis

Publikováno v: Proceedings of the National Academy of Sciences. 82:7560-7564

Early region 1 of the adenovirus type 5 genome was replaced with a DNA sequence containing the gene coding for the hepatitis B surface antigen (HBsAg) flanked by the major late promoter from adenovirus 2 and processing and polyadenylylation signals f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee393227490e2d46d485840ce29bc5d
https://doi.org/10.1073/pnas.82.22.7560

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