A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity.

Autor: Hossain MI; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Roulston CL; O'Brien Institute, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia; Centre for Eye Research Australia, University of Melbourne, Gisborne Street, East Melbourne 3002, Australia., Kamaruddin MA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Chu PWY; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Ng DCH; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Dusting GJ; O'Brien Institute, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia; Centre for Eye Research Australia, University of Melbourne, Gisborne Street, East Melbourne 3002, Australia., Bjorge JD; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Health Sciences Centre, Calgary, Alberta T2N 4N1, Canada., Williamson NA; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Fujita DJ; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Health Sciences Centre, Calgary, Alberta T2N 4N1, Canada., Cheung SN; Centre for Cellular and Molecular Biology, School of Life and Environmental Sciences, Deakin University, Burwood, Victoria 3125, Australia., Chan TO; Department of Medicine, Center for Translational Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107., Hill AF; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia., Cheng HC; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, 30 Flemington Road, Parkville, Victoria 3010, Australia. Electronic address: heung@unimelb.edu.au.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2013 Apr 05; Vol. 288 (14), pp. 9696-9709. Date of Electronic Publication: 2013 Feb 11.