Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Chu Kong Liew"'
Autor:
James L. J. Coleman, Tony Ngo, Johannes Schmidt, Nadine Mrad, Chu Kong Liew, Nicole M. Jones, Robert M. Graham, Nicola J. Smith
Publikováno v:
Science Signaling. 12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::525515f3441b51e5e0dcf4c08efdff26
https://doi.org/10.1126/scisignal.aba2063
https://doi.org/10.1126/scisignal.aba2063
Autor:
Johannes Schmidt, Chu Kong Liew, Robert M. Graham, Tony Ngo, Nicole M. Jones, Nadine Mrad, Nicola J. Smith, James L. J. Coleman
Publikováno v:
Science Signaling. 9
Little is known about the pharmacology or physiology of GPR37L1, a G protein (heterotrimeric guanine nucleotide-binding protein)-coupled receptor that is abundant in the cerebellum. Mice deficient in this receptor exhibit precocious cerebellar develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c91d2f807103eb5e4918034abbbddb
https://doi.org/10.1126/scisignal.aad1089
https://doi.org/10.1126/scisignal.aad1089
Autor:
Chu Kong Liew, Maryrose Constantine, Victor Lo, Charles G. Cranfield, Margaret Sunde, Alexander Macmillan, Boris Martinac, Robert M. Graham, Renee Whan
Publikováno v:
Scientific Reports
Mutation, irregular expression and sustained activation of the Transient Receptor Potential Channel, type Melastatin 4 (TRPM4), have been linked to various cardiovascular diseases. However, much remains unknown about the structure of this important i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4f8fd0eabccb534a4291cff8e2934d
Autor:
Joel P. Mackay, Piotr G. Fajer, Chu Kong Liew, Louise J. Brown, David A. Gell, Nicole M. Cordina
Publikováno v:
Protein Science. 21:1376-1387
Cardiac troponin C (cTnC) is the calcium binding subunit of the troponin complex that triggers the thin filament response to calcium influx into the sarcomere. cTnC consists of two globular EF-hand domains (termed the N- and C-domains) connected by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d253cfa5869d7977ca0e644d0ef6412f
https://doi.org/10.1002/pro.2124
https://doi.org/10.1002/pro.2124
Autor:
Chu Kong Liew, Robert T. Clubb, Michael E. Jung, Nuttee Suree, William Thieu, Valerie A. Villareal, Evgeny A. Fadeev, Jeremy J. Clemens
Publikováno v:
Journal of Biological Chemistry. 284:24465-24477
In Gram-positive bacteria, sortase enzymes assemble surface proteins and pili in the cell wall envelope. Sortases catalyze a transpeptidation reaction that joins a highly conserved LPXTG sorting signal within their polypeptide substrate to the cell w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b48a966da199b732aff8bb0d7c8ba4
https://doi.org/10.1074/jbc.m109.022624
https://doi.org/10.1074/jbc.m109.022624
Autor:
William Thieu, Udayar Ilangovan, Nuttee Suree, Jeremy J. Clemens, Robert T. Clubb, Mandar T. Naik, Dean Campbell, Chu Kong Liew, Michael E. Jung
Publikováno v:
Journal of Biological Chemistry. 281:1817-1826
Many virulence factors in Gram-positive bacteria are covalently anchored to the cell-wall peptidoglycan by sortase enzymes, a group of widely distributed cysteine transpeptidases. The Staphylococcus aureus Sortase A protein (SrtA) is the archetypal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83890637e70f244a4a5ea07cf62c195a
https://doi.org/10.1074/jbc.m506123200
https://doi.org/10.1074/jbc.m506123200
Autor:
Dean O. Campbell, Nuttee Suree, Robert T. Clubb, Rosemarie M. Pilpa, Michael E. Jung, Jeremy J. Clemens, Chu Kong Liew
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5076-5079
l -Threonine 2 was converted in seven steps into the protected aminomercaptoalcohol 8, a threonine mimic. This compound 8 was coupled to various oligopeptides to produce two different tetrapeptide analogues, for example, 11 and 17, which were shown t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24e6580f7b1d23882fe97d1e96757495
https://doi.org/10.1016/j.bmcl.2005.07.073
https://doi.org/10.1016/j.bmcl.2005.07.073
Autor:
Belinda K. Sharpe, Jacaqueline M Matthews, Ann H. Kwan, Chu Kong Liew, Merlin Crossley, Jacqueline A. Wilce, Joel P. Mackay
Publikováno v:
Structure. 13:257-266
Zinc binding motifs have received much attention in the area of protein design. Here, we have tested the suitability of a recently discovered nonnative zinc binding structure as a protein design scaffold. A series of multiple alanine mutants was crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6aaeb670589c2edc3e3d4ccd54a87298
https://doi.org/10.1016/j.str.2004.12.007
https://doi.org/10.1016/j.str.2004.12.007
Autor:
Joel P. Mackay, Fionna E. Loughlin, Merlin Crossley, Jacqueline M. Matthews, Chu Kong Liew, Linda Crofts, Raina J. Simpson, Ann H. Kwan
Publikováno v:
Proceedings of the National Academy of Sciences. 102:583-588
GATA-1 and friend of GATA (FOG) are zinc-finger transcription factors that physically interact to play essential roles in erythroid and megakaryocytic development. Several naturally occurring mutations in the GATA-1 gene that alter the FOG-binding do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1af0cfa05caeb633b8776e7c83ba541
https://doi.org/10.1073/pnas.0407511102
https://doi.org/10.1073/pnas.0407511102
Autor:
Joel P. Mackay, Anthea L. Newton, Belinda K. Sharpe, Merlin Crossley, Archa H. Fox, Chu Kong Liew, Kasper Kowalski
Publikováno v:
Structure. 8(11):1157-1166
Background: Zinc finger domains have traditionally been regarded as sequence-specific DNA binding motifs. However, recent evidence indicates that many zinc fingers mediate specific protein–protein interactions. For instance, several zinc fingers fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eefc86f50cf2152f651f1b3d6eecd11b