Xanthohumol Protects Against Neuronal Excitotoxicity and Mitochondrial Dysfunction in APP/PS1 Mice: An Omics-Based Study.

Autor: Hu FF; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Pan SY; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Chu JY; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Liu JJ; Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China., Duan TT; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Luo Y; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Zhou W; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Wang ZM; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China., Liu W; Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China., Zeng Y; Hubei Provincial Clinical Research Center for Alzheimer's Disease, Wuhan University of Science and Technology, Wuhan 430065, China.; Brain Science and Advanced Technology Institute, Medical School, Wuhan University of Science and Technology, Wuhan 430065, China.

Publikováno v: Nutrients [Nutrients] 2024 Oct 31; Vol. 16 (21). Date of Electronic Publication: 2024 Oct 31.

Megastudy testing 25 treatments to reduce antidemocratic attitudes and partisan animosity.

Autor: Voelkel JG; Brooks School of Public Policy, Cornell University, Ithaca, NY 14850, USA., Stagnaro MN; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Chu JY; Department of Sociology, Columbia University, New York, NY 10027, USA., Pink SL; Wharton School, University of Pennsylvania, Philadelphia, PA 19104, USA., Mernyk JS; Department of Sociology, Stanford University, Stanford, CA 94305, USA., Redekopp C; Department of Sociology, Stanford University, Stanford, CA 94305, USA., Ghezae I; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Cashman M; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Adjodah D; MIT Media Lab, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Allen LG; Department of Political Science, Indiana State University, Terre Haute, IN 47809, USA., Allis LV; ActiVote, Boston, MA 02111, USA., Baleria G; Civity, San Francisco, CA 94109, USA.; Department of Communication and Media Studies, Sonoma State University, Rohnert Park, CA 94928, USA., Ballantyne N; School of Historical, Philosophical, and Religious Studies, Arizona State University, Tempe, AZ 85281, USA., Van Bavel JJ; Department of Psychology, New York University, New York, NY 10003, USA.; Department of Strategy & Management, Norwegian School of Economics, Bergen, 5045, Norway., Blunden H; Kogod School of Business, American University, Washington, DC 20016, USA., Braley A; Department of Political Science, University of California, Berkeley, Berkeley, CA 94720, USA., Bryan CJ; McCombs School of Business, The University of Texas at Austin, Austin, TX 78705, USA., Celniker JB; School of Historical, Philosophical, and Religious Studies, Arizona State University, Tempe, AZ 85281, USA., Cikara M; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Clapper MV; College of Liberal Arts, The University of Texas at Austin, Austin, TX 78712, USA., Clayton K; Department of Political Science, Stanford University, Stanford, CA 94305, USA., Collins H; Harvard Business School, Harvard University, Boston, MA 02163, USA., DeFilippis E; Harvard Business School, Harvard University, Boston, MA 02163, USA., Dieffenbach M; Constructive Dialogue Institute, New York, NY 10016, USA., Doell KC; Department of Psychology, New York University, New York, NY 10003, USA.; Centre for the Advanced Study of Collective Behaviour, University of Konstanz, Konstanz, 78464, Germany., Dorison C; McDonough School of Business, Georgetown University, Washington, DC 20057, USA., Duong M; Constructive Dialogue Institute, New York, NY 10016, USA., Felsman P; Department of Sociology, Anthropology, Social Work and Criminal Justice, Oakland University, Rochester, MI 48309, USA., Fiorella M; Civity, San Francisco, CA 94109, USA.; Department of Communication and Media Studies, Sonoma State University, Rohnert Park, CA 94928, USA., Francis D; Information Technology, Bowdoin College, Brunswick, ME 04011, USA., Franz M; Department of Government and Legal Studies, Bowdoin College, Brunswick, ME 04011, USA., Gallardo RA; The University of Chicago Booth School of Business, University of Chicago, Chicago, IL 60637, USA., Gifford S; ActiVote, Boston, MA 02111, USA., Goya-Tocchetto D; Fuqua School for Business, Duke University, Durham, NC 27708, USA., Gray K; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA., Green J; Centre for Applied Moral Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Greene J; Department of Psychology, Harvard University, Cambridge, MA 02138, USA., Güngör M; Department of Psychological Science, University of California, Irvine, Irvine, CA 92617, USA., Hall M; Department of Political Science, University of Notre Dame, Notre Dame, IN 46556, USA., Hecht CA; Department of Psychology, University of Rochester, Rochester, NY 14627, USA., Javeed A; Department of Psychology, New York University, New York, NY 10003, USA., Jost JT; Department of Psychology, New York University, New York, NY 10003, USA., Kay AC; Fuqua School for Business, Duke University, Durham, NC 27708, USA., Kay NR; Centre for Applied Moral Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Keating B; YOUnify, Salt Lake City, UT 84106, USA., Kelly JM; Department of Psychological Science, University of California, Irvine, Irvine, CA 92617, USA., Kirk JRG; Department of Political Science, University of Notre Dame, Notre Dame, IN 46556, USA., Kopell M; Civity, San Francisco, CA 94109, USA., Kteily N; Kellogg School of Management, Northwestern University, Evanston, IL 60208, USA., Kubin E; Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.; Department of Psychology, Rhineland-Palatinate Technical University Kaiserslautern-Landau, Landau in der Pfalz, 76829, Germany., Lees J; Department of Human Resource Management and Organizational Behavior, University of Groningen, Groningen, 9747 AE, Netherlands., Lenz G; Department of Political Science, University of California, Berkeley, Berkeley, CA 94720, USA., Levendusky M; Department of Political Science, University of Pennsylvania, Philadelphia, PA 19104, USA., Littman R; Department of Psychology, University of Illinois Chicago, Chicago, IL 60607, USA., Luo K; Center for International Development, Harvard University, Cambridge, MA 02138, USA., Lyles A; CommonAlly, Washington, DC 20036, USA., Lyons B; Department of Communication, University of Utah, Salt Lake City, UT 84112, USA., Marsh W; Department of Political Science, University of Tennessee, Knoxville, TN 37916, USA., Martherus J; Morning Consult, Washington, DC 20004, USA., Maurer LA; Constructive Dialogue Institute, New York, NY 10016, USA., Mehl C; Constructive Dialogue Institute, New York, NY 10016, USA., Minson J; Center for Public Leadership, Harvard Kennedy School, Cambridge, MA 02138, USA., Moore M; Department of Economics, Washington University in St. Louis, St. Louis, MO 63105, USA., Moore-Berg SL; Department of Psychology, University of Utah, Salt Lake City, UT 84112, USA., Pasek MH; Department of Psychology, University of Illinois Chicago, Chicago, IL 60607, USA.; Beyond Conflict, Boston, MA 02116, USA., Pentland A; Stanford Institute for Human-Centered Artificial Intelligence, Stanford University, Stanford, CA 94305, USA., Puryear C; Kellogg School of Management, Northwestern University, Evanston, IL 60208, USA., Rahnama H; School of Media, Toronto Metropolitan University, Toronto, ON M5B 2K3, Canada., Rathje S; Department of Psychology, New York University, New York, NY 10003, USA., Rosato J; CommonAlly, Washington, DC 20036, USA., Saar-Tsechansky M; McCombs School of Business, The University of Texas at Austin, Austin, TX 78705, USA., Almeida Santos L; Department of Psychology, Stanford University, Stanford, CA 94305, USA., Seifert CM; Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA., Shariff A; Department of Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada., Simonsson O; Department of Clinical Neuroscience, Karolinska Institute, Solna, 171 65, Sweden., Spitz Siddiqi S; Department of Psychological Science, University of California, Irvine, Irvine, CA 92617, USA., Stone DF; Department of Economics, Bowdoin College, Brunswick, ME 04011, USA., Strand P; Civity, San Francisco, CA 94109, USA.; Negotiation and Conflict Resolution Program, Creighton University, Omaha, NE 68178, USA.; Marquette University Law School, Milwaukee, WI 53233, USA., Tomz M; Department of Political Science, Stanford University, Stanford, CA 94305, USA.; Stanford Institute for Economic Policy Research, Stanford University, Stanford, CA 94305, USA., Yeager DS; Department of Psychology, The University of Texas at Austin, Austin, TX 78712, USA., Yoeli E; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Zaki J; Department of Psychology, Stanford University, Stanford, CA 94305, USA., Druckman JN; Department of Political Science, University of Rochester, Rochester, NY 14627, USA., Rand DG; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Willer R; Department of Sociology, Stanford University, Stanford, CA 94305, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2024 Oct 18; Vol. 386 (6719), pp. eadh4764. Date of Electronic Publication: 2024 Oct 18.

Academics are more specific, and practitioners more sensitive, in forecasting interventions to strengthen democratic attitudes.

Autor: Chu JY; Department of Sociology, Columbia University, New York, NY 10027., Voelkel JG; Department of Sociology, Stanford University, Stanford, CA 94305., Stagnaro MN; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139., Kang S; Perry World House, University of Pennsylvania, Philadelphia, PA 19104., Druckman JN; Department of Political Science, University of Rochester, Rochester, NY 14627., Rand DG; Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA 02139., Willer R; Department of Sociology, Stanford University, Stanford, CA 94305.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Jan 16; Vol. 121 (3), pp. e2307008121. Date of Electronic Publication: 2024 Jan 12.

Dock2 generates characteristic spatiotemporal patterns of Rac activity to regulate neutrophil polarisation, migration and phagocytosis.

Autor: Machin PA; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Johnsson AE; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Massey EJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Pantarelli C; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Chetwynd SA; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Chu JY; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Okkenhaug H; Imaging Facility, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Segonds-Pichon A; Bioinformatics Facility, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Walker S; Imaging Facility, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom., Malliri A; Cell Signalling, Cancer Research UK Manchester Institute, Manchester, United Kingdom., Fukui Y; Division of Immunogenetics, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan., Welch HCE; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jun 13; Vol. 14, pp. 1180886. Date of Electronic Publication: 2023 Jun 13 (Print Publication: 2023).

Age-related decline in the resistance of mice to bacterial infection and in LPS/TLR4 pathway-dependent neutrophil responses.

Autor: Hornigold K; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Chu JY; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Chetwynd SA; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Machin PA; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Crossland L; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Pantarelli C; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Anderson KE; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Hawkins PT; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom., Segonds-Pichon A; Bioinformatics Facility, The Babraham Institute, Cambridge, United Kingdom., Oxley D; Proteomics Facility, The Babraham Institute, Cambridge, United Kingdom., Welch HCE; Signalling Programme, The Babraham Institute, Cambridge, United Kingdom.

Publikováno v: Frontiers in immunology [Front Immunol] 2022 Aug 24; Vol. 13, pp. 888415. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).