DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2.

Autor: Parzych EM; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Du J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA., Ali AR; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Schultheis K; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Frase D; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Smith TRF; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Cui J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA., Chokkalingam N; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Tursi NJ; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Andrade VM; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Warner BM; Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada., Gary EN; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Li Y; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Choi J; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Eisenhauer J; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Maricic I; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Kulkarni A; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Chu JD; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Villafana G; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Rosenthal K; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Ren K; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Francica JR; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Wootton SK; Department of Pathobiology, University of Guelph, Guelph, ON, N1G 2W1, Canada., Tebas P; University of Pennsylvania, Philadelphia, PA, 19104, USA., Kobasa D; Public Health Agency of Canada, Winnipeg, MB, R3E 3R2, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB, R3E 0J9, Canada., Broderick KE; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Boyer JD; Inovio Pharmaceuticals, Plymouth Meeting, PA, 19462, USA., Esser MT; Vaccines and Immune Therapies, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, 20878, USA., Pallesen J; Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, IN, 47405, USA., Kulp DW; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Patel A; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA., Weiner DB; The Vaccine and Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, PA, 19104, USA. dweiner@wistar.org.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 06; Vol. 13 (1), pp. 5886. Date of Electronic Publication: 2022 Oct 06.

Synthetic DNA Delivery of an Optimized and Engineered Monoclonal Antibody Provides Rapid and Prolonged Protection against Experimental Gonococcal Infection.

Autor: Parzych EM; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA., Gulati S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Zheng B; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Bah MA; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA., Elliott STC; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA., Chu JD; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA., Nowak N; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Reed GW; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Beurskens FJ; Genmab, Utrecht, The Netherlands., Schuurman J; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Rice PA; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA., Weiner DB; Vaccine & Immunotherapy Center, The Wistar Institute of Anatomy and Biology, Philadelphia, Pennsylvania, USA., Ram S; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA sanjay.ram@umassmed.edu.

Publikováno v: MBio [mBio] 2021 Mar 16; Vol. 12 (2). Date of Electronic Publication: 2021 Mar 16.

Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig.

Autor: Xu Z; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States., Wise MC; Inovio Pharmaceuticals, Plymouth Meeting, PA 19422, United States., Choi H; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Perales-Puchalt A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Patel A; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Tello-Ruiz E; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Chu JD; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Muthumani K; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States., Weiner DB; Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA 19104, United States. Electronic address: dweiner@wistar.org.

Publikováno v: EBioMedicine [EBioMedicine] 2018 Sep; Vol. 35, pp. 97-105. Date of Electronic Publication: 2018 Aug 30.