Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Chu J. Chen"'
Publikováno v:
Journal of Bone and Mineral Research. 2:319-327
A newly developed calcium-sensitive dye, Fura-2, was employed in dispersed bovine parathyroid cells to study the effects of extracellular calcium and magnesium on cytosolic calcium concentration and parathyroid hormone (PTH) release. In comparison wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f06aef5d706bc0cc5bc9cfea029fb5
https://doi.org/10.1002/jbmr.5650020409
https://doi.org/10.1002/jbmr.5650020409
Publikováno v:
Endocrinology. 131:903-910
We previously showed that the polycationic aminoglycoside antibiotic neomycin mimics the effects of high extracellular calcium (Ca2+) concentrations on several aspects of parathyroid function. In the present studies we examined the actions of several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777b3f594180ff435beb2c74ff91bf02
https://doi.org/10.1210/endo.131.2.1322287
https://doi.org/10.1210/endo.131.2.1322287
Publikováno v:
Endocrinology. 127:1064-1071
We compared the effects of a series of di- and trivalent cations on various aspects of parathyroid function to investigate whether these polyvalent cations act on the parathyroid cell through a similar mechanism. Like high extracellular concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561e4d0bc6846ef989288c39c498961b
https://doi.org/10.1210/endo-127-3-1064
https://doi.org/10.1210/endo-127-3-1064
Autor:
Edward M. Brown, Olga Kifor, Meryl S. LeBoff, G. El-Hajj, Vera Fajtova, Chu J. Chen, L.T. Rubin
Publikováno v:
Cell Calcium. 11:333-337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c922eb05791c4fe00802dcb164bacdb
https://doi.org/10.1016/0143-4160(90)90035-s
https://doi.org/10.1016/0143-4160(90)90035-s
Autor:
Caren M. Gundberg, Paul R. Conlin, Edward M. Brown, Pamela J. Johnson, Chu J. Chen, Fredrick D. Grant, Meryl S. LeBoff
Publikováno v:
The Journal of clinical endocrinology and metabolism. 72(2)
Although levels of serum osteocalcin are thought to be an indicator of osteoblastic activity and bone formation, there is little information regarding the acute effects of changes in calcium or PTH levels on circulating osteocalcin concentrations. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d46e30b19f2f9316810e6dcdbc43eb01
https://pubmed.ncbi.nlm.nih.gov/1991812
https://pubmed.ncbi.nlm.nih.gov/1991812
Publikováno v:
Bone and mineral. 11(3)
The addition of protons to the medium of neonatal mouse calvaria cultures stimulated bone resorption and release of calcium into the medium. In addition, added protons significantly increased the release of prostaglandin E2 (PGE2) and cyclic adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2af414732fd2ec5d04881cbcf2fe766
https://pubmed.ncbi.nlm.nih.gov/1964815
https://pubmed.ncbi.nlm.nih.gov/1964815
Autor:
Edward M. Brown, Chu J. Chen
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 5(6)
We previously showed that the calcium channel blocker diltiazem raises cytosolic Ca2+ and inhibits PTH release in bovine parathyroid cells. To investigate further possible mechanisms underlying these effects, we examined the effects of the more poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f45ac98de30508b953c472800a36e0b1
https://pubmed.ncbi.nlm.nih.gov/2166422
https://pubmed.ncbi.nlm.nih.gov/2166422
Autor:
Edward M. Brown, S. Levy, Linda Swiston, Marguerite Oetting, Chu J. Chen, Meryl S. LeBoff, Joseph Preston
Publikováno v:
Endocrinology. 121:1571-1576
Unlike most secretory cells, high extracellular Ca2+ inhibits, rather than stimulates, PTH release from parathyroid cells. To gain more direct access to the potentially unique secretory apparatus of this cell type, we developed techniques for permeab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6b263ee2c611e76fb5e5db6b58359f
https://doi.org/10.1210/endo-121-4-1571
https://doi.org/10.1210/endo-121-4-1571
Publikováno v:
Endocrinology. 124:233-239
We used pertussis toxin to study the mechanism(s) by which divalent cations lower cellular cAMP content in bovine parathyroid cells. In cultured parathyroid cells, high extracellular Ca2+ (5 mM) or Mg2+ (5-10 mM) lowers dopamine-stimulated cAMP conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02341d3251f0a32cf438447bb257444d
https://doi.org/10.1210/endo-124-1-233
https://doi.org/10.1210/endo-124-1-233
Publikováno v:
Endocrinology. 121:958-964
We have examined possible mechanisms by which osmolality might modulate PTH secretion in dispersed bovine parathyroid cells. Increasing medium osmolality by adding sodium chloride causes a marked, dose-dependent increase in PTH release. The maximum e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dde79bc7bb1d9ff2f5187d480e91254
https://doi.org/10.1210/endo-121-3-958
https://doi.org/10.1210/endo-121-3-958